期刊
JOURNAL OF NATURAL PRODUCTS
卷 77, 期 3, 页码 557-562出版社
AMER CHEMICAL SOC
DOI: 10.1021/np400814w
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资金
- NCCR Chemical Biology
- R'Equip grant [206021_150760]
- Swiss National Science Foundation
- Swiss National Science Foundation (SNF) [206021_150760] Funding Source: Swiss National Science Foundation (SNF)
The isolation and structural characterization of three new heterocyclic and macrocyclic peptides, balgacyclamides A C, from Microcystis aeruginosa EAWAG 251 are reported. The constitutions were determined by 2D-NMR methods and mass spectrometry, and the configurations were assigned after ozonolysis and hydrolysis by HPLC-MS methods using Marfey's method as well as GC-MS using authentic standards. Balgacyclamides A and B were active against Plasmodium falciparum K1 in the low micromolar range, while displaying low toxicity to rat myoblasts.
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