期刊
JOURNAL OF NATURAL PRODUCTS
卷 76, 期 12, 页码 2350-2354出版社
AMER CHEMICAL SOC
DOI: 10.1021/np400546z
关键词
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资金
- NSFC [81373290]
- CAS [KSCX2-EW-Q-10]
- 973 Programs [2009CB522300, 2009CB930300]
- NSFYP [2012FB178]
- SRF for ROCS, SEM
Three new triterpenoids, kadcotriones A-C (1-3), together with the biogenetically related lanostane-type triterpenoid (4), were isolated from Kadsura coccinea. Compound 1 features a 12,14 beta-dimethyl 6/6/6-fused tricyclic skeleton, while 2 and 3 are characterized by a 6/6/5-ring system. Their structures were determined by NMR and electronic circular dichroism spectroscopic methods. Compounds 2 and 4 exhibited anti-HIV-1 activities with EC50 values of 30.29 and 54.81 mu M, respectively.
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