☆ 4.7 Article

Polycyclic Hybrid Isoprenoids from a Reed Rhizosphere Soil Derived Streptomyces sp CHQ-64

JOURNAL OF NATURAL PRODUCTS (2013)

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期刊

JOURNAL OF NATURAL PRODUCTS
卷 76, 期 4, 页码 759-763

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AMER CHEMICAL SOC
DOI: 10.1021/np3008864

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Plant Sciences Chemistry, Medicinal Pharmacology & Pharmacy

资金

  1. National Natural Science Foundation of China [21102137, 41176120]
  2. National High Technology Research and Development Program of China [2013AA092901]
  3. Chinese Polar Environment Comprehensive Investigation & Assessment Programmes [CHINARE2013-01-06-06]
  4. Provincial Natural Science Foundation of Shandong [ZR2010HM057]
  5. Promotive Research Fund for Excellent Young and Middle-Aged Scientisits of Shandong Province [BS2010HZ027]
  6. State Oceanic Administration [2010418022-3]
  7. Program for Changjiang Scholars and Innovative Research Team in University [IRT0944]

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Two new hybrid isoprenoids, named indotertine B (2) and drimentine H (3), along with the known analogue drimentine C (4), were isolated from the reed rhizosphere soil derived actinomycete Streptomyces sp. CHQ-64. The structures of these compounds, including absolute configurations, were elucidated by extensive NMR, MS, and CD analyses. Indotertine B (2) exists as a pair of rotamers about the N-C(O) bond with a 2:1 ratio and displays activities against HCT-8 and A549 tumor cell lines with IC50 values of 6.96 and 4.88 mu M, respectively.

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