Chemoenzymatic Total Synthesis of the Phytotoxic Geranylcyclohexentriol (-)-Phomentrioloxin

The enantiomeric form, 1R, of the structure (IS) assigned to the phytotoxic natural product phomentrioloxin has been synthesized in seven steps from the homochiral cis-1,2-dihydrocatechol 3. These studies reveal that the true structure of phomentrioloxin is represented by 1R and not by 1S.