期刊
JOURNAL OF NATURAL PRODUCTS
卷 76, 期 11, 页码 2141-2144出版社
AMER CHEMICAL SOC
DOI: 10.1021/np400609f
关键词
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资金
- German Academic Exchange Service (DAAD)
- Thai Royal Golden Ph.D. Jubilee-Industry program (RGJ)
- Thailand Research Fund [BRG5580009]
- [Ph.D/0138/2553]
- [24.S.MF/53/A.3]
A chlorinated isocoumarin with an acetylenyl side chain and its 3,4-dihydro derivative, named gymnopalynes A (1) and B (2), were isolated from cultures of a basidiomycete originating from the rain forest of Northern Thailand. The producing organism was identified as a species of Gymnopus (Marasmiaceae). Their structures were elucidated by spectroscopic methods including UV/vis and NMR spectroscopy as well as high-resolution mass spectrometry as 3-(3-chloroprop-1-yn-1-yl)-1H-isochromen-1-one (1) and 3(3-chloroprop-1-yn-1-yl)-3,4-dihydro-1H-isochromen-1-one (2). The absolute stereochemistry of 2 was assigned as S by CD spectroscopy. Both compounds showed weak to moderate antimicrobial and pronounced cytotoxic activities.
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