期刊
JOURNAL OF NATURAL PRODUCTS
卷 75, 期 6, 页码 1076-1082出版社
AMER CHEMICAL SOC
DOI: 10.1021/np200960z
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资金
- National Natural Science Foundation of China [30830114, 31100259]
- National Basic Research Program of China (973 Program) [2009CB522303, 2009CB940900]
- Young Academic and Technical Leader Raising Foundation of Yunnan Province [2010CI047]
Ten new yuzurine-type Daphniphyllum alkaloids, daphmacromines A-J (1-10), along with seven known alkaloids were isolated from the leaves and stems of Daphniphyllum macropodum. Their structures were elucidated by extensive spectroscopic techniques, including 2D NMR spectroscopy and mass spectrometry, and the structure of 1 was confirmed by single-crystal X-ray diffraction. The pesticidal and cytotoxic activities of the isolated alkaloids were evaluated in vitro against brine shrimp (Artemia sauna) and five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480), respectively. This study also suggested structural revisions of oxodaphnigracine, oxodaphnigraciline, and epioxodaphnigraciline.
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