Article
Plant Sciences
Dipesh Dhakal, Sofia Kokkaliari, Garret M. Rubin, Valerie J. Paul, Yousong Ding, Hendrik Luesch
Summary: In this study, a biosynthetic gene cluster (BGC) for Lyngbyastatins (Lbns) was identified and characterized in a marine cyanobacterium. The BGC was found to encode enzymes responsible for the production of compounds 1 and 2, which have anti-cancer activity. Similar BGCs were also identified in the genomes of other marine cyanobacteria.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Plant Sciences
Jiyoon Park, Jiseong Kim, Sunghoon Hwang, Daehyun Oh, Young Eun Du, Sang-Jip Nam, Hyeung-geun Park, Min Jae Lee, Dong-Chan Oh
Summary: New sulfur-bearing natural products, sadopeptins A and B, were discovered from Streptomyces sp. YNK18 through a targeted search using the isotopic signature of sulfur. The compounds were determined to be new cyclic heptapeptides with specific functional groups through NMR spectroscopy and other analyses. The findings also revealed the presence of a biosynthetic gene cluster and proposed a potential biosynthetic pathway. The sadopeptins showed proteasome-inhibitory activity without affecting cellular autophagic flux.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Environmental Sciences
Nian Wei, Aifa Chen, Xiaohe Guo, Shubing Zhang, Lirong Song, Nanqin Gan, Lingling Zheng, Yunlu Jia, Jie Li
Summary: This study investigated the changes in nitrogen metabolism in phosphorus-starved bloom-forming cyanobacteria. The results showed that decreased expression of nitrogen source transporters led to reduced nitrogen uptake and nitrogen deficiency. Additionally, phosphorus starvation resulted in a drastic decrease in phycocyanin content. While external nitrogen supply did not significantly alter the transcription of nitrogen metabolism-related genes, it still helped to maintain the survival of phosphorus-starved cells.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Analytical
Yijun Yuan, Xiaoqing Liao, Ziyi Fang, Nana Liu, Fengfang Qiu, Dejuan Huang, Binliang Wang, Yunyue Zhou
Summary: In order to achieve environmental sustainability, a raw bloom-forming species Microcystis aeruginosa was used for the biosorption of uranium without any modification. The adsorption experiments showed that the process of U(VI) adsorption on M. aeruginosa was pH-dependent, endothermic and spontaneous. The analysis of FTIR and XPS indicated the significant role of oxygenated functional groups of M. aeruginosa in uranium biosorption. The high adsorption capacity and satisfactory regeneration availability of M. aeruginosa enable the possibility of treating 'polluter (radioactive wastewater)' with 'polluter (toxic cyanobacteria)'.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2022)
Article
Virology
Fei Wang, Dengfeng Li, Ruqian Cai, Lingting Pan, Qin Zhou, Wencai Liu, Minhua Qian, Yigang Tong
Summary: This study isolated a cyanophage named Mae-Yong1326-1 using Microcystis aeruginosa as an indicator host. Mae-Yong1326-1 has a wide host range, stable characteristics, and a large burst size. Genome comparison and protein tree analysis revealed that Mae-Yong1326-1 belongs to an unknown new genus. This study enriched the understanding of freshwater cyanophages.
Article
Biochemistry & Molecular Biology
Nurul Farhana Salleh, Jiale Wang, Binu Kundukad, Emmanuel T. Oluwabusola, Delia Xin Yin Goh, Ma Yadanar Phyo, Jasmine Jie Lin Tong, Staffan Kjelleberg, Lik Tong Tan
Summary: Marine cyanobacteria produce bioactive specialized metabolites during blooms to defend against competing microbes and herbivores. Two compounds, benderadiene and lyngbyoic acid, were discovered from a marine cyanobacterium and found to inhibit gene expression in a dose-dependent manner. Lyngbyoic acid also displayed anti-biofilm activity. The discovery of these compounds provides insights into their ecological significance and potential as starting materials for analogs.
Article
Chemistry, Organic
Arihiro Iwasaki, Naoaki Kurisawa, Tingting Wang, Xiaohui Li, Haixi Luo, Chengcong Zhu, Gaurav Patial, Xiaojun Yan, Shan He, Tal Luzzatto-Knaan, Fuli Tian, C. Benjamin Naman, Kiyotake Suenaga
Summary: Lingaoamide is a new cyclic heptapeptide natural product isolated from a freshwater Oscillatoria cyanobacterium collected in Lingao County, Hainan, China. It up-regulates melanogenesis in the rice blast fungus and exhibits weak inhibition against Gram-negative Pseudomonas aeruginosa and Gram-positive Bacillus pumilus in vitro. It does not affect plant growth or immune response in vivo using Arabidopsis thaliana as a model organism.
TETRAHEDRON LETTERS
(2021)
Article
Plant Sciences
Aki Yamano, Yuka Asato, Noriyuki Natsume, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya
Summary: Odookeanynes A and B, two acetylene-containing lipopeptides, were isolated from a marine cyanobacterium collected in Okinawa, Japan. Their structures were elucidated through spectroscopic analysis and Marfey's analysis. These compounds dose-dependently promoted the differentiation of mouse 3T3-L1 preadipocytes in the presence of insulin.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biotechnology & Applied Microbiology
Daichi Morimoto, Naohiro Yoshida, Aya Sasaki, Satoshi Nakagawa, Yoshihiko Sako, Takashi Yoshida
Summary: The bloom-forming toxic cyanobacterium Microcystis aeruginosa interacts with diverse broad- and narrow-host-range viruses. However, the dynamics of the Microcystis population (at the intraspecies level) and viruses with different host ranges remain unknown.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Plant Sciences
Li-Qin Shen, Zhong-Chun Zhang, Jin-Long Shang, Zheng-Ke Li, Min Chen, Renhui Li, Bao-Sheng Qiu
Summary: In this study, a strain of cyanobacteria capable of producing chlorophyll f under far-red light was taxonomically transferred to the genus Kovacikia and established as a new species called Kovacikia minuta sp. nov. Phylogenetic analysis revealed its relationship with other Kovacikia strains, and the draft genome provided insights into its genetic characteristics. This study contributes to our understanding of the diversity of chlorophyll f-producing cyanobacteria and lays a foundation for future research on the evolution of far-red light photoacclimation in cyanobacteria.
JOURNAL OF PHYCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Benjamin L. Springstein, Dennis J. Nurnberg, Christian Woehle, Julia Weissenbach, Marius L. Theune, Andreas O. Helbig, Iris Maldener, Tal Dagan, Karina Stucken
Summary: Filament-forming proteins play crucial roles in cellular processes such as cell division and growth. Two novel coiled-coil-rich proteins in the filament-forming cyanobacterium Anabaena assemble into heteropolymers and function in maintaining the multicellular shape. Their function is achieved through cooperation with other proteins to stabilize the cell shape.
Article
Microbiology
Ve Van Le, So-Ra Ko, Mingyeong Kang, Hee-Mock Oh, Chi-Yong Ahn
Summary: A novel species of the genus Hymenobacter, named Hymenobacter cyanobacteriorum sp. nov., was isolated from a eutrophic reservoir. This strain showed differences in morphology and genetic sequences compared to related strains.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Marine & Freshwater Biology
Adam Antosiak, Sigitas Sulcius, Przemys law Malec, Nada Tokodi, Antonia Lobodzinska, Dariusz Dziga
Summary: This study investigated the changes in photosynthetic activity and carbon metabolism of cyanobacteria infected by cyanophages. The results showed that the photosynthetic activity and CO2 fixation potential of cyanobacteria decreased after phage infection, leading to a lower efficiency of carbon and energy cycling. This could have cascading effects on other non-infected members of the microbial community.
Article
Limnology
Judith M. Noronha, Manguesh U. Gauns, Sanjeev C. Ghadi
Summary: This article describes a filamentous cyanobacterium, Limnothrix sp. VL01, and a novel lytic cyanophage, "phi L-VL01", that infects it, isolated from a shallow freshwater lake in Goa, India. The study found that cyanophage-infected Limnothrix sp. VL01 showed reduced growth and increased fragmentation compared to uninfected control. This suggests that "phi L-VL01" could be an important agent in controlling cyanobacterial blooms.
Article
Microbiology
Hannah Schaetzle, Sergio Arevalo, Leonard Fresenborg, Hans-Michael Seitz, Enrique Flores, Enrico Schleiff
Summary: In the model cyanobacterium Anabaena sp. strain PCC 7120, TonB proteins such as TonB3 are involved in transporting ferric schizokinen, while TonB2 mutations strongly influence outer membrane integrity. The different TonB proteins appear to have distinct functions and play important roles in cellular metal concentrations and antibiotic susceptibility.
