期刊
JOURNAL OF NATURAL PRODUCTS
卷 75, 期 4, 页码 771-773出版社
AMER CHEMICAL SOC
DOI: 10.1021/np200862y
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资金
- Division of Cancer Treatment and Diagnosis, NCI, DHHS [CA-10612-02, CA-10612-3, 5 R01 CA090441-07]
- Arizona Biomedical Research Commission
- J. W. Kieckhefer Foundation
- Margaret T. Morris Foundation
- Robert B. Dalton Endowment Fund
Bioassay-guided (cancer cell line) separation of an extract prepared from Narcissus cv. Ice Follies (from The Netherlands) led to the isolation of a new Amaryllidaceae isocarbostiryl, 3-epipancratistatin (1b), as well as narciclasine (2). This Narcissus cultivar was found to be a good source of narciclasine. The structure of 1b was established by high-resolution mass and high-field 2D NMR spectroscopic analyses. Against a panel of murine and human cancer cell lines, 3-epipancratistatin (1b) led to cell growth inhibition (GI(50) 2.2-0.69 mu g/mL) some 100X less than that found for pancratistatin (1a) and narciclasine (2), thereby revealing an important configurational requirement in la for strong cancer cell growth inhibition.
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