期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 6, 页码 1503-1507出版社
AMER CHEMICAL SOC
DOI: 10.1021/np100937e
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资金
- PICT-BID [38219]
- UBACYT [B114]
Vicenin-2 (1), a flavonoid glycoside, was isolated and identified from an ethanol extract of the aerial parts of Urtica circularis. This crude extract was found to possess significant anti-inflammatory activity in a carrageenan-induced rat hind paw edema model (41.5% inhibition at a dose of 300 mg/kg; ip). The effects of 1 on several inflammatory mediators were investigated. In cultured murine macrophages, this compound modified LPS-induced total nitrite and TNF-alpha production, in addition to the LPS-induced translocation of the nuclear factor NF-kappa B.
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