期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 5, 页码 1021-1027出版社
AMER CHEMICAL SOC
DOI: 10.1021/np100923z
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资金
- National Science Council of the Republic of China [NSC 95-2320-B-127-001-MY3, NSC 98-2320-B-127-001-MY3]
Five new compounds, 9-O-angeloyl-8,10-dehydrothymol (1), 9-(3-methylbutanoyl)-8,10-dehydrothymol (2), eupatobenzofuran (3), 2-hydroxy-2,6-dimethylbenzofuran-3 (2H)-one (4), and 1-(2-hydroxy-4-methylphenyl)propan-1,2-dione (5), have been isolated from the aerial part of Eupatorium cannabinum subsp. asiaticum, together with 16 known compounds (6-21). Compounds 6-8, 11, 13, and 15 exhibited inhibition (IC50 values <= 18.4 mu M) of superoxide anon generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 2, 3, 10, 13, and 15 inhibited fMLP/CB-induced elastase release with IC50 values <= 18.3 mu M.
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