期刊
JOURNAL OF NATURAL PRODUCTS
卷 74, 期 10, 页码 2151-2160出版社
AMER CHEMICAL SOC
DOI: 10.1021/np2004566
关键词
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资金
- National Natural Sciences Foundation of China (NNSFC) [20772156, 30825044, 20932007]
- National Science and Technology Project of China [2009ZX09311-004]
Homosecoiridoids (1-15) were isolated from the flower buds of Lonicera japonica. Compounds 1-4, designated as loniphenyruviridosides A D, possess unprecedented skeletons featuring phenylpyruvic acid derived moieties coupled with an iridoid or a secoiridoid nucleus. Compounds 5-15 (lonijaposides D-N) are additional examples of the unusual pyridinium alkaloid-coupled secoiridoids (lonijaposides A C). The validity of the CD data to determine the configuration of the secoiridoid derivatives is discussed on the basis of detailed CD data analysis and semisynthesis of 2 and 3 with the co-occurring secologanic acid. The configuration of secologanic acid was determined by a single-crystal X-ray crystallographic analysis using anomalous scattering of Cu K alpha radiation. Biosynthetic pathways of the homosecoiridoids were postulated. Compounds 1-4 inhibited,STAT-3 activity of HELF cells, and lonijaposides F (7), H (9), I (10), and K (12) showed activity against the release of glucuronidase in rat polymorphonuclear leukocytes induced by platelet-activating factor.
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