☆ 4.7 Article

Chemical Constituents from the Leaves and Stems of Schisandra rubriflora

JOURNAL OF NATURAL PRODUCTS (2010)

期刊

JOURNAL OF NATURAL PRODUCTS

卷 73, 期 2, 页码 221-225

出版社

AMER CHEMICAL SOC

DOI: 10.1021/np900849y

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类别

Plant Sciences Chemistry, Medicinal Pharmacology & Pharmacy

资金

NSFC [20802082, 30830115]
Chinese Academy of Sciences [KSCX1-YW-R-24]
Major State Basic Research Development program of China [2009CB522303, 2009CB940900]
Young Academic and Technical Leader Rising Foundation of Yunnan province [2006PY0147]
Natural Science Foundation of Yunnan Province [2005XY04, 2006B0042Q]

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摘要

Six new nortriterpenoids, schirubridilactones A-F (1-6). as well as 14 known compounds, were isolated from the leaves and stems of Schisandra rubriflora. The Structures of 1-6 were elucidated oil the basis of spectroscopic methods including HSQC, HMBC, H-1-H-1 COSY, and ROESY NMR experiments. The relative stereochemistry of I was confirmed through single-crystal X-ray analysis. In addition, compounds 1-6 showed anti-HIV-1 activity with EC50 values in the range 14.3-80.8 mu g/mL and Selectivity indices in the range 2.2-9.0.

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