期刊
JOURNAL OF NATURAL PRODUCTS
卷 73, 期 7, 页码 1228-1233出版社
AMER CHEMICAL SOC
DOI: 10.1021/np100048h
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资金
- National Science Council, Republic of China [NSC 98- 2320-11002-027-MY3]
Fractionation of an acetone extract from the fruits of Schisandra arisanensis afforded live new nortriterpene lactones, compounds 1-5, together with four known compounds, schindilactones D and E (6 and 7) and preschisanartanins A and B (8 and 9). Compound 1, a wuweiziartane-type nortriterpenoid, possesses a new type of fused ring system with a gamma-lactone ring between C-15 and C-17. Compounds 2, 6, and 7 may be categorized as schisanartane-type nortriterpenoids and compounds 3-5, 8, and 9 as preschisanartane-type nortriterpenoids. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopic data interpretation. The structure and relative configuration of 3 were supported by single-crystal X-ray diffraction analysis. The antiviral activity against HSV-1 and inhibitory effects on superoxide anion generation and elastase release by human neutrophils in response to FMLP/CB of compounds 1-9 were evaluated.
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