Article
Environmental Sciences
Luciana C. Furtado, Anelize Bauermeister, Rafael de Felicio, Raquel Ortega, Francisco das Chagas L. Pinto, Joao Agostinho Machado-Neto, Daniela B. B. Trivella, Otilia D. L. Pessoa, Diego V. Wilke, Norberto P. Lopes, Paula C. Jimenez, Leticia V. Costa-Lotufo
Summary: The study showed that cytotoxic extracts produced by marine bacteria recovered from the Brazilian endemic ascidian Euherdmania sp. have potential as proteasome inhibitors, with the extract from marine Streptomyces sp. BRA-346 displaying potent proteasome inhibitory activity. Both the extract and its dihydroeponemycin compound exhibited high cytotoxicity in glioma cell lines, suggesting potential for further development in targeted cancer therapy.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Plant Sciences
Kantinan Leetanasaksakul, Wilaiwan Koomsiri, Takuya Suga, Hirotaka Matsuo, Rei Hokari, Pakorn Wattana-Amorn, Yoko Takahashi, Kazuro Shiomi, Takuji Nakashima, Yuki Inahashi, Arinthip Thamchaipenet
Summary: Sattahipmycin is a novel polycyclic xanthone isolated from marine-derived Streptomyces sp. GKU 257-1, which exhibits antibiofilm, antibacterial, and anticancer activities.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Infectious Diseases
Ramon Santamaria, Ana Martinez-Carrasco, Jesus Martin, Jose R. Tormo, Ignacio Perez-Victoria, Ignacio Gonzalez, Olga Genilloud, Fernando Reyes, Margarita Diaz
Summary: Xylem sap from grapevines has a positive effect on antibiotic production in Streptomyces bacteria, inducing the production of known compounds and new unidentified compounds. The active fraction of the sap contains small molecules that act as elicitors, but there may be other unidentified elicitors involved.
Article
Microbiology
Jose Diogo Neves dos Santos, Ines Rosado Vitorino, Nicolai Kallscheuer, Akash Srivastava, Sebastian Krautwurst, Manja Marz, Christian Jogler, Alexandre Lobo-da-Cunha, Jose Catita, Hugo Goncalves, Ignacio Gonzalez, Fernando Reyes, Olga Maria Lage
Summary: A novel actinomycetal strain, M600PL45_2T, was isolated from marine sediments at Ingleses beach in Porto, Portugal. The strain exhibits brown pigment production, helical hyphae, and smooth spores. Phylogenetic analysis revealed high similarity to two Streptomyces species. The strain was named Streptomyces marispadix sp. nov.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2023)
Article
Chemistry, Medicinal
Zhikai Guo, Shiying Ma, Salman Khan, Hongjie Zhu, Bo Zhang, Shiqing Zhang, Ruihua Jiao
Summary: Marine-derived Streptomyces sp. ITBB-ZKa6 led to the discovery of two unique antimycin-type depsipeptides, zhaoshumycins A and B, along with four known neoantimycins. The structures of the new compounds were elucidated based on diverse spectroscopic data and biogenetic consideration. Further structure-activity relationship analysis suggested the importance of certain functional groups for cytotoxicity in MCF7 cells.
Article
Microbiology
Yu Chen, Lian-Cheng Xu, Shan Liu, Zi-Xiang Zhang, Guan-Yi Cao
Summary: Halometabolites are important natural halogenated compounds produced in marine environments. They have diverse structures and significant biological activities, making them potential lead compounds for drug discovery. This review focuses on the chemodiversity and bioactivity of halometabolites from marine-derived fungi. A total of 145 naturally halogenated compounds, including chlorinated, brominated, and iodinated compounds, were isolated from 17 genera of marine-derived fungi. These compounds belong to different structural types, such as polyketides, phenols, alkaloids, and terpenoids. They exhibit cytotoxic, antibacterial, and anti-inflammatory activities.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Organic
Vijayaragavan Elumalai, Tomaz Trobec, Maja Grundner, Christophe Labriere, Robert Frangez, Kristina Sepcic, Jorn H. Hansen, Johan Svenson
Summary: This study presents a method for designing cholinesterase inhibitors based on marine pharmacophores. The compounds were evaluated for their inhibitory activity against different cholinesterase enzymes and showed higher inhibitory potency compared to clinically used drugs. Additionally, the compounds demonstrated low toxicity in mammalian cells.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ying-Yue Yang, Wan-Li Wang, Xia-Tong Hu, Xin Chen, Yang Ni, Yan-Hua Lei, Qi-Yuan Qiu, Long-Yue Tao, Tian -Wen Luo, Ning-Yu Wang
Summary: The mammalian target of rapamycin (mTOR) has been proven to be an effective target for cancer therapy. Rapalogs and mTOR kinase inhibitors (TORKi) have been developed and clinically validated in several types of malignancies, with TORKi showing better antitumor activity by inhibiting both mTORC1 and mTORC2. However, the clinical development of current TORKi candidates has been relatively slow, and there is a need to develop more TORKi with novel scaffold to expand the current pipelines.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Iza Mirela Rodini Garcia-Princival, Jefferson Luiz Princival, Emmanuel Dias da Silva, Sandrine Maria de Arruda Lima, Jhonattas Carvalho Carregosa, Alberto Wisniewski Jr, Caio Cezar Oliveira de Lucena, Fernando Halwass, Jose Adonias Alves Franca, Luiz Felipe Gomes Rebello Ferreira, Marcelo Zaldini Hernandes, Karina Lidianne Alcantara Saraiva, Christina Alves Peixoto, Blandine Baratte, Thomas Robert, Stephane Bach, Dayene Correia Gomes, Patricia Maria Guedes Paiva, Pascal Marchand, Maria Desterro Rodrigues, Teresinha Goncalves da Silva
Summary: The study demonstrated cytotoxic activity of Nigericin against several cancer cell lines, especially HL-60 and HCT-116. Nigericin induced apoptosis and autophagy in HCT-116 cells. Additionally, Nigericin was able to inhibit JAK3 and GSK-3 beta kinases in vitro and its binding affinities were mapped through intermolecular interactions with each target in silico.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Applied
Bing Zhang, Yu-ying Zhao, Zhi-pu Huang, Ke-tao Zhang, Xiao-rong Xu, Qing Zhao, Xiao-mei Zhang
Summary: A new compound and a new natural product were isolated from marine Streptomyces sp. YIM 13591. Their structures and configurations were determined using various methods, and their antimicrobial effects were evaluated.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Medicinal
Chao Ge, Lu Liu, Yanqing Wang, Xiaojiao Di, Xiangjie Luo, Hongke Liu, Yong Qian
Summary: This study focuses on the cytotoxicity and mode of action of naphthalimide derivatives, particularly the anticancer activity and demethylase inhibition by compounds 1 and 7.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Multidisciplinary Sciences
Bahaa Abdella, Mohamed Abdella, Hafed A. ElSharif, Amani M. D. ElAhwany, Nermeen A. El-Sersy, Hanan A. Ghozlan, Soraya A. Sabry
Summary: This study investigates the synthesis of anti-Candida metabolites by Streptomyces sp. HC14 recovered from a soft coral, aiming to develop new therapeutic approaches. Compounds were identified using GC-MS, and a cheminformatics approach was employed to identify potential active components. The compounds identified with high activity potential were pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(phenylmethyl)-3, and di-n-octyl. This discovery reduces the need for chemical synthesis and fermentation optimization maximizes their synthesis, providing a strong foundation for the development of novel anti-Candida albicans agents.
SCIENTIFIC REPORTS
(2023)
Article
Materials Science, Multidisciplinary
Jian Wang, Min Du, Xueyan Shan
Summary: The effects of marine Streptomyces on the corrosion process of X65 steel were investigated. The production of organic acid by Streptomyces accelerated the corrosion rate initially, but the formation of a special honeycomb corrosion product structure promoted the enrichment of protein/polysaccharide on the metal surface, leading to a denser biomineralized film and reduced corrosion rate, especially localized corrosion. However, in the later stage, the shedding of the protective film layer intensified the corrosion, although no obvious pitting corrosion was observed. The unique antimicrobial-like metabolites have potential applications in microbiologically influenced corrosion inhibition.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Plant Sciences
Min Cheol Kim, Zhifei Li, Reiko Cullum, Tadeusz F. Molinski, Mennat Allah G. Eid, Ali M. S. Hebishy, Ahmed H. I. Faraag, Ahmed E. Abdel Moneim, Mohamed S. Abdelfattah, William Fenical
Summary: The antibacterial metabolites from the Streptomyces sp. EG32 isolated in this study showed activity against MRSA, with chlororesistoflavins A and B exhibiting minimum inhibitory concentrations of 0.25 and 2.0 μg/mL, respectively. Chiroptical analysis revealed the configurations of these metabolites to be identical to that of natural resistoflavin.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Multidisciplinary Sciences
Prasenjit Das, Shampa Kundu, Pulak Kumar Maiti, Saurodeep Mandal, Prithidipa Sahoo, Sukhendu Mandal
Summary: Selective isolation of soil Actinobacteria led to the discovery of a new class of antibiotics called pyrimidomycin, produced by Streptomyces sp. PSAA01. Pyrimidomycin showed potential in terms of antimicrobial spectrum and activity, and exhibited synergy with commonly used antibiotics.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Ruben L. Rodriguez-Exposito, Nathalia Nocchi, Maria Reyes-Batlle, Ines Sifaoui, Blanca Suarez-Gomez, Ana R. Diaz-Marrero, Maria L. Souto, Jose E. Pinero, Jose J. Fernandez, Jacob Lorenzo-Morales
Summary: Studies have shown that certain sesquiterpene lactones isolated from the indigenous zoanthid Palythoa aff. clavata collected at the coast of Lanzarote, Canay Islands exhibit anti-amoebic effects, with 4-epi-arbusculin A and isobadgerin showing promising activity and low cytotoxicity. The mode of action of compounds 2 and 11 on Acanthamoeba castellanii Neff involves induction of PDC mechanisms.
BIOORGANIC CHEMISTRY
(2021)
Article
Parasitology
Olfa Chiboub, Ines Sifaoui, Manef Abderrabba, Mondher Mejri, Jose J. Fernandez, Ana R. Diaz-Marrero, Jacob Lorenzo-Morales, Jose E. Pinero
Summary: The study found that three isolated diterpenes could induce apoptosis-like cell death in tested parasites, inhibiting L. amazonensis and T. cruzi. These results support further investigation on these compounds as potential drug candidates.
PARASITES & VECTORS
(2021)
Review
Environmental Sciences
Ana Rotter, Michele Barbier, Francesco Bertoni, Atle M. Bones, M. Leonor Cancela, Jens Carlsson, Maria F. Carvalho, Marta Ceglowska, Jeronimo Chirivella-Martorell, Meltem Conk Dalay, Mercedes Cueto, Thanos Dailianis, Irem Deniz, Ana R. Diaz-Marrero, Dragana Drakulovic, Arita Dubnika, Christine Edwards, Hjoerleifur Einarsson, Aysegul Erdogan, Orhan Tufan Eroldogan, David Ezra, Stefano Fazi, Richard J. FitzGerald, Laura M. Gargan, Susana P. Gaudencio, Marija Gligora Udovic, Nadica Ivosevic DeNardis, Rosa Jonsdottir, Marija Katarzyte, Katja Klun, Jonne Kotta, Leila Ktari, Zrinka Ljubesic, Lada Lukic Bilela, Manolis Mandalakis, Alexia Massa-Gallucci, Inga Matijosyte, Hanna Mazur-Marzec, Mohamed Mehiri, Soren Laurentius Nielsen, Lucie Novoveska, Donata Overlinge, Giuseppe Perale, Praveen Ramasamy, Celine Rebours, Thorsten Reinsch, Fernando Reyes, Baruch Rinkevich, Johan Robbens, Eric Roettinger, Vita Rudovica, Jerica Sabotid, Ivo Safarik, Siret Talve, Deniz Tasdemir, Xenia Theodotou Schneider, Olivier P. Thomas, Anna Torunska-Sitarz, Giovanna Cristina Varese, Marlen Vasquez
Summary: Coastal countries have traditionally relied on marine resources for various needs, while modern societies have increased demands for diverse products leading to the emergence of blue biotechnology. This field offers opportunities for commercial interests in pharmaceuticals, cosmetics, food, and related industries. Exploration of marine resources and their potential applications in various sectors are highlighted, along with the importance of legislation, funding, communication, and stakeholder engagement in the development of marine biotechnology.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Environmental Sciences
Sara Garcia-Davis, Carolina P. Reyes, Irene Lagunes, Jose M. Padron, Eugenio Fraile-Nuez, Jose J. Fernandez, Ana R. Diaz-Marrero
Summary: Marine ecosystems are unique and rich sources of biodiversity, with marine microbiota showing promise for drug development. Research on the Tagoro submarine volcano has identified various marine bacterial strains and their antiproliferative activities, highlighting the potential for accessing novel secondary metabolites and enzymes for pharmaceutical and industrial applications.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Parasitology
Ruben L. Rodriguez-Exposito, Javier Sosa-Rueda, Maria Reyes-Batlle, Ines Sifaoui, Francisco Cen-Pacheco, Antonio Hernandez Daranas, Ana R. Diaz-Marrero, Jose E. Pinero, Jose J. Fernandez, Jacob Lorenzo-Morales
Summary: The study found that the cyclooctapeptides squamins C-F from Annona globiflora exhibit anti-amoeboid activity against Acanthamoeba, especially sensitive to A. castellanii Neff. These peptides can induce programmed cell death in Acanthamoeba, causing mitochondrial damage and increased production of reactive oxygen species (ROS), but they have no cytotoxic effects on murine macrophages.
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
(2021)
Article
Chemistry, Medicinal
Carlos J. Bethencourt-Estrella, Nathalia Nocchi, Atteneri Lopez-Arencibia, Desiree San Nicolas-Hernandez, Maria L. Souto, Blanca Suarez-Gomez, Ana R. Diaz-Marrero, Jose J. Fernandez, Jacob Lorenzo-Morales, Jose E. Pinero
Summary: Leishmaniasis and Chagas disease are neglected tropical diseases that are prevalent in developing countries, with limited treatment options and high toxicity of current drugs. Recent research has focused on finding innovative therapies, including sesquiterpene lactones from marine organisms, which have shown potential in combating these diseases.
Article
Medicine, Research & Experimental
Inigo Arberas-Jimenez, Aitor Rizo-Liendo, Nathalia Nocchi, Ines Sifaoui, Javier Chao-Pellicer, Maria L. Souto, Blanca Suarez-Gomez, Ana R. Diaz-Marrero, Jose J. Fernandez, Jose E. Pinero, Jacob Lorenzo-Morales
Summary: This study tested the anti-amoebic activity of sesquiterpene lactones isolated from a zoanthid on Naegleria fowleri and found two compounds with the best activity. Additionally, the mechanisms of cell death induction by these compounds were evaluated.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Inigo Arberas-Jimenez, Sara Garcia-Davis, Aitor Rizo-Liendo, Ines Sifaoui, Ezequiel Q. Morales, Jose E. Pinero, Jacob Lorenzo-Morales, Ana R. Diaz-Marrero, Jose F. Fernandez
Summary: Primary amoebic meningoencephalitis (PAM) is a CNS disease caused by Naegleria fowleri, which mainly affects children and young adults with high fatality rate. The marine environment is a valuable source of anti-Naegleria compounds. This study focuses on Laurencia cyclolaurane-type sesquiterpenes as potential chemical models for PAM treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Nathalia Nocchi, Alejandro Gonzalez-Orive, Alberto Hernandez-Creus, Jacob Lorenzo-Morales, Adriana Rodriguez, Rodrigo Morchon, Ana R. Diaz-Marrero, Jose J. Fernandez
Summary: Millepora alcicornis, also known as fire coral, is a tropical hydrozoa species that produces thermolabile proteins, including phospholipase A2 (PLA2) and alciporin, a pore-forming protein (PFP). The venom contained in the nematocysts of this species displays hemolytic activity primarily through the action of alciporin, which targets sphingomyelin. Atomic force microscopy (AFM) was used to study the evolution of hemolytic damage at the nanoscale.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Maria Jose Ramos-Sosa, Victor Hernandez Lopez, Andres Sanchez-Henao, Natalia Garcia-Alvarez, Ana R. Diaz-Marrero, Inmaculada Rosario, Fernando Real, Jose J. Fernandez
Summary: Ciguatera poisoning (CP) is a well-known foodborne disease, but little research has been done on the effects of ciguatoxins (CTXs) on fish metabolism. This study examined the changes in hepatic compounds in goldfish (Carassius auratus) fed C-CTX1 using NMR-based metabolomics. The results showed that the fish fed toxic flesh had increased liver size and altered concentrations of alanine, lactate, taurine, glucose, and glycogen. These changes may be linked to an increase in ammonium ion production.
Article
Chemistry, Medicinal
Inigo Arberas-Jimenez, Nathalia Nocchi, Javier Chao-Pellicer, Ines Sifaoui, Angelica Ribeiro Soares, Ana R. R. Diaz-Marrero, Jose J. Fernandez, Jose E. Pinero, Jacob Lorenzo-Morales
Summary: This study aimed to identify new anti-Naegleria marine natural products from a collection of chamigrane-type sesquiterpenes with structural variety, and (+)-Elatol was found to be the most effective compound against Naegleria fowleri.
Article
Chemistry, Medicinal
Sara Garcia-Davis, Atteneri Lopez-Arencibia, Carlos J. Bethencourt-Estrella, Desiree San Nicolas-Hernandez, Ezequiel Viveros-Valdez, Ana R. Diaz-Marrero, Jose J. Fernandez, Jacob Lorenzo-Morales, Jose E. Pinero
Summary: In this study, it was found that five compounds isolated from the red alga Laurencia johnstonii exhibited leishmanicidal activity. Among them, laurequinone showed the strongest activity and was capable of inducing programmed cell death or apoptosis in the parasite. These findings highlight the potential of laurequinone as a novel therapeutic agent against kinetoplastid parasites.
Review
Chemistry, Medicinal
Susana P. Gaudencio, Engin Bayram, Lada Lukic Bilela, Mercedes Cueto, Ana R. Diaz-Marrero, Berat Z. Haznedaroglu, Carlos Jimenez, Manolis Mandalakis, Florbela Pereira, Fernando Reyes, Deniz Tasdemir
Summary: Natural Products (NP) play a crucial role in the discovery of novel drugs and biotechnological applications. However, the process of NP discovery is expensive and time-consuming, mainly due to the challenges of dereplication and structure elucidation, especially for metabolites with stereogenic centers. This review highlights recent technological and instrumental advances that address these obstacles and accelerate NP discovery for biotechnological applications. It emphasizes innovative high-throughput tools and methods for bioactivity screening, NP chemical analysis, dereplication, metabolite profiling, metabolomics, genome sequencing and/or genomics approaches, databases, bioinformatics, chemoinformatics, and three-dimensional NP structure elucidation.
Article
Parasitology
Inigo Arberas-Jimenez, Francisco Cen-Pacheco, Javier Chao-Pellicer, Ines Sifaoui, Aitor Rizo-Liendo, Ezequiel Q. Morales, Antonio H. Daranas, Ana R. Diaz-Marrero, Jose E. Pinero, Jose J. Fernandez, Jacob Lorenzo-Morales
Summary: This study evaluated the in vitro activity of six oxasqualenoids obtained from the red algae Laurencia viridis against N. fowleri, as well as their cytotoxicity against murine macrophages. Yucatecone showed the highest selectivity index and induce programmed cell death in treated amoebae. The presence of a ketone at C-18 was found to be the significant structural feature for activity against N. fowleri.
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
(2023)
Article
Chemistry, Medicinal
Inigo Arberas-Jimenez, Ruben L. Rodriguez-Exposito, Desiree San Nicolas-Hernandez, Javier Chao-Pellicer, Ines Sifaoui, Ana R. Diaz-Marrero, Jose J. Fernandez, Jose E. Pinero, Jacob Lorenzo-Morales
Summary: In this study, six meroterpenoids isolated from the brown algae Gongolaria abies-marina were evaluated for their activity against N. fowleri. Three compounds, Gongolarone B (1), 6Z-1-methoxyamentadione (2), and 1-methoxyamentadione (3), showed the most activity against N. fowleri, with IC50 values ranging from 13.27±0.96μM to 21.92±1.60μM. Cystomexicone B (6) exhibited the highest selectivity index (>8.5). Moreover, all these compounds induced cellular events related to apoptosis-like programmed cell death. Therefore, G. abies-marina could be a promising source of active molecules for treating N. fowleri infections.
