期刊
JOURNAL OF NATURAL PRODUCTS
卷 73, 期 1, 页码 60-66出版社
AMER CHEMICAL SOC
DOI: 10.1021/np900622m
关键词
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资金
- Fogarty International Center (FIC) International Cooperative Biodiversity Group (ICBG) [ICBG U01 TW006634]
- FIC International Research Scientist Development Award (IRSDA) [K01 TW008002]
- NIH [T32 CA009523]
- FOGARTY INTERNATIONAL CENTER [K01TW008002, U01TW006634] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [T32CA009523] Funding Source: NIH RePORTER
Tropical parasitic and infectious diseases, such as leislimaniasis, pose enormous global health threats, but are largely neglected in commercial drug discovery programs. However, the Panama International Cooperative Biodiversity Group (ICBG) has been working to identify novel treatments for malaria, Chagas' disease, and leishmaniasis through an investigation of plants and microorganisms from Panama. We have pursued activity-guided isolation from an extract of Lyngbya majuscula that was found to be active against leishmaniasis. A new modified linear peptide from the dragonamide series was isolated, dragonamide E (1). along with two known modified linear peptides, dragonamide A (2) and herbamide B (3). Dragonamides A and E and herbamide B exhibited antileishmanial activity with IC50 values of 6.5, 5.1, and 5.9 mu M, respectively. Spectroscopic and stercochemical data for dragonamide E (1) and herbamide B (3; the spectroscopic and stereochemical data for this Substance is incomplete in the literature) are presented as well as comparisons of biological activity within the dragonamide compound family. Biosynthetic differences among marine compounds with a terminal free amide are also discussed.
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