期刊
JOURNAL OF NATURAL PRODUCTS
卷 72, 期 12, 页码 2120-2124出版社
AMER CHEMICAL SOC
DOI: 10.1021/np900160g
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资金
- Bundesministerium fur Bildung and Forschung (BMBF) [03F0415A]
Chemical screening of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate Mei37 resulted in five isoquinolinequinones, four new derivatives, mansouramycin A-D (1, 3-5), and the known 3-methyl-7-(methylamino)-5,8-isoquinolinedione (2). Their structures were elucidated by NMR and MS techniques and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated significant cytotoxicity of several derivatives, with pronounced selectivity for non-small cell lung cancer, breast cancer, melanoma, and prostate cancer cells.
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