期刊
JOURNAL OF NATURAL PRODUCTS
卷 72, 期 3, 页码 366-371出版社
AMER CHEMICAL SOC
DOI: 10.1021/np800603u
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资金
- National Cancer Institute, DHHS [CA44344-10-12, R01 CA90441-01-05, 2R56 CA090441-06A1, 5R01 CA090441-07]
- Fannie E. Rippel Foundation
- Arizona Disease Control Research Commission
- Robert B. Dalton Endowment Fund
- NATIONAL CANCER INSTITUTE [R01CA090441, R56CA090441, R35CA044344] Funding Source: NIH RePORTER
Two new cyclodepsipeptides designated bacillistatins 1 (1) and 2 (2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI(50)'s of 10(-4)-10(-5) mu g/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. ne structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.
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