期刊
JOURNAL OF NATURAL PRODUCTS
卷 72, 期 9, 页码 1678-1681出版社
AMER CHEMICAL SOC
DOI: 10.1021/np900292e
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资金
- NSFC [30830115, 20802082]
- Chinese Academy of Sciences [KSCX1-YW-R-24]
- 973 Program [2009CB522303, 2009CB522306, 2009CB940900]
- Scientific and Technological Projects of China [2009ZX09501-029]
- Yong Academic and Technical Leader Rising Foundation of Yunnan Province [2006PY01-47]
- Natural Science Foundation of Yunnan Province [2005XY04, 2006B0042Q]
Three new nortriterpenoids, schigrandilactones A-C (1-3), along with eight known compounds, were isolated from an organic solvent extract of Schisandra grandiflora. Compounds I and 2 feature a spirocyclic moiety in their structures, and compound 3 was characterized with a new oxygenated pattern. The relative configurations of 1 and 3 were determined through single-crystal X-ray experiments. In addition, compounds 1 and 2 displayed cytotoxic activity against two human cancer cell lines, and compound 3 showed anti-HIV-1 inhibition in infected C8166 cells.
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