期刊
JOURNAL OF NATURAL PRODUCTS
卷 72, 期 12, 页码 2169-2171出版社
AMER CHEMICAL SOC
DOI: 10.1021/np800778b
关键词
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资金
- National Research Foundation, South Africa
- South African Medical Research Council (TB Epidemiology and Intervention Research Unit, Pretoria)
The bioassay-guided fractionation of the EtOH extract of the leaves of Galenia africana led to the isolation of three known flavonoids, (2S)-5,7,2'-trihydroxyflavanone (1), (E)-3,2',4'-trihydroxychalcone (2), and (E)-2',4'-dihydroxychalcone (3), and the new (E)-3,2',4'-trihydroxy-3'-methoxychalcone (4). Compounds 1 and 3 exhibited moderate antituberculosis activity. During synergistic studies, a combination of compound 4 and an existing antituberculosis drug, isoniazid, reduced their original MICs 4-fold, resulting in a fractional inhibitory concentration of 0.50. The most pronounced effect was demonstrated by compound I and isoniazid reducing their MICs 16-fold and resulting in an FIC of 0.12. Both EtOH extract and isolated compounds failed to exhibit any NADPH oxidase activity at 800.0 mu M concentrations, indicating that mycothiol disulfide reductase is not the target for their antituberculosis activity.
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