4.7 Article

Phenylethanoid Glycosides from Lantana fucata with in Vitro Anti-inflammatory Activity

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JOURNAL OF NATURAL PRODUCTS
卷 72, 期 8, 页码 1424-1428

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AMER CHEMICAL SOC
DOI: 10.1021/np9002383

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  1. CNPq
  2. FAPERJ
  3. CAPES
  4. Gonqalves-Salimena, Universidade Federal de Juiz de Fora, Minas Gerais, Brazil

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A phytochemical analysis of Lantana fucata dried leaves led to the isolation of three new phenylethanoid glycosides, fucatosides A-C, along with parvifloroside A and six known methoxyflavones. Their structures were established by NMR and ESIMS experiments. In vitro assays showed that the alcoholic extract and fucatoside C have significant anti-inflammatory effects, inhibiting NO release in the LPS-induced J774.Al murine macrophage cell line.

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