期刊
JOURNAL OF NATURAL PRODUCTS
卷 71, 期 8, 页码 1431-1440出版社
AMER CHEMICAL SOC
DOI: 10.1021/np800269k
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资金
- NIDA [Y1-DA6002]
The first enantiospecific total synthesis of (+)-alstonisine has been accomplished from D-tryptophan methyl ester 13 ill 12% overall yield (in 17 reaction vessels). A diastereospecific osmylation process has been employed as a key step to convert indole 18 into spirocyclic oxindole 19. Mechanistic studies of the stereoselective osmylation of the 2,3-indole double bond of indole alkaloids has been carried Out. Compelling evidence for the intramolecular delivery of OsO4 via N-b-complexation was obtained for the osmylation process. The correct structure of (+)-alstonisine (1) was determined by NOE spectroscopic experiments and further confirmed by single-crystal X-ray analysis.
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