期刊
JOURNAL OF NATURAL PRODUCTS
卷 71, 期 9, 页码 1569-1573出版社
AMER CHEMICAL SOC
DOI: 10.1021/np800281f
关键词
-
资金
- the National Institutes of Health [CA 102102]
Two new anticancer antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate extract of a culture broth of the terrestrial Streptomzyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human lung cancer and MCF-7 human breast cancer cells.
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