Article
Chemistry, Multidisciplinary
Yu-pei Yang, Yu-qing Jian, Yong-bei Liu, Muhammad Ismail, Qing-ling Xie, Huang-he Yu, Bin Wang, Bin Li, Cai-yun Peng, Bin Liu, Rong-yong Man, Wei Wang
Summary: A variety of new lanostane triterpenoids and their derivatives were isolated from Heilaohu, showing potential anti-inflammatory and anti-rheumatoid activities by significantly inhibiting IL-6 and TNF-alpha levels.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Qi-Qi Zhang, Kun Hu, Han-Dong Sun, Pema-Tenzin Puno
Summary: Four new 14(13 -> 12)-abeolanostane triterpenoids, named kadcoccitanes E-H (1-4), were isolated from the stems of Kadsura coccinea. Their structures and configurations were determined through spectroscopic analysis and quantum chemical calculations. However, these compounds showed no cytotoxic activities against the tested human tumor cell lines at a concentration of 40 μM.
NATURAL PRODUCTS AND BIOPROSPECTING
(2023)
Article
Biochemistry & Molecular Biology
Tianming Zhao, Chao Ma, Guofei Zhu
Summary: The chemical composition and biological activities of the essential oils from Kadsura coccinea were investigated. The essential oils showed weak antioxidant activities and cholinesterase inhibition activities. They exhibited inhibitory effects against Staphylococcus aureus, with the highest antimicrobial activity observed in the root oil. High potential for applications in food and pharmaceutical industries.
Article
Food Science & Technology
Zhi-Ling Jin, Ke Han, Hao-Yang Chen, Xiang-Yun Zhang, Wei-Li Qiao, Bei-Xi Jia
Summary: An approach combining LC-MS analysis, network pharmacological prediction, and experimental validation was used to explore the phytochemicals and biological functions of Kadsura coccinea peri-carpium (KCP). It was found that KCP contains various lignans and triterpenoids, which act on key targets through multiple signaling pathways to achieve different biofunctions. Experimental validation showed that certain triterpenoid acids in KCP effectively decreased breast cancer cell viability and the KCP extract demonstrated anti-tumor efficacy in mice by modulating immunity and activating the MAPK signal pathway. These findings provide valuable information for developing high value-added products of Kadsura coccinea.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Chemistry, Organic
Jiaxin Tian, Kunyu Li, Guanghai Ma, Gang Chen, Feng Gao
Summary: This study conducted phytochemical research on the root of Kadsura coccinea and isolated a previously undescribed compound. The compound exhibited moderate immune-suppressive activity, suggesting its potential use in the treatment of rheumatic diseases.
LETTERS IN ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Xueqing Zhang, Xiaoxu Gao, Guoqing Long, Yongcheng Yang, Gang Chen, Guoli Hou, Xuting Huo, Jingming Jia, Anhua Wang, Gaosheng Hu
Summary: This study isolated and identified 10 undescribed lanostane triterpenoids and 21 known compounds from statically cultured mycelial mat of G. lucidum. The hepatoprotective activities of these compounds in H2O2-induced HepG2 cells were evaluated, and the structure-activity relationship was discussed.
Article
Chemistry, Applied
Shi-Tao Wang, Te-Ri-Gen Bao, Peng-Kun Qi, Tao Liu
Summary: Wolfiporia cocos is a traditional Chinese medicine with diuretic, tonifying, and invigorating effects on the spleen. The discarded epidermis of W. cocos was studied and three new lanostane triterpenoids were isolated. The structures were determined and the compounds showed no inhibition against indicator microbes. This study provides a reference for further medicinal development and utilization of W. cocos.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yu-Ting Li, Zhen Zhang, Yunjiang Feng, Yuanyuan Cheng, Shuyuan Li, Can Li, Li-Wen Tian
Summary: Seven undescribed 22-hydroxylanostane triterpenoids were isolated from the fruiting bodies of Phellinus igniarius, with their structures determined by extensive spectroscopic and HRESIMS data analyses. Stereoselective synthesis of 22S/22R25,26,27-Trinorlanosta-8-en-3 beta,22,24-triols was achieved for the first time, with cardioprotective activity demonstrated by Phellinols A, B, and F.
Article
Biochemistry & Molecular Biology
Yan-Zhe Jia, Yu-Pei Yang, Shao-Wu Cheng, Liang Cao, Qing-Ling Xie, Meng-Yun Wang, Bin Li, Yu-Qing Jian, Bin Liu, Cai-Yun Peng, Wei Wang
Summary: Phytochemical investigations on fresh fruits of Kadsura coccinea led to the isolation of several new lignan compounds, some of which exhibited strong hepatoprotective activities against APAP-induced toxicity.
Article
Chemistry, Applied
Chunjiao Jiang, Jiancheng Ji, Peihai Li, Wenfeng Liu, Hao Yu, Xiuqing Yang, Lili Xu, Lizhong Guo, Yaqin Fan
Summary: Two new lanostane-type triterpenoids, ganoderenicfys A (1) and B (2), along with six known related terpenoids, were isolated from Ganoderma applanatum. Their structures were determined through detailed NMR and HRESIMS analysis, with the absolute configurations of 1 and 2 confirmed through quantum chemical ECD calculations. These compounds were found to exhibit proangiogenic activities in a zebrafish model, with compounds 1, 2, and 4 showing significant promotion of angiogenesis, marking the first report of such activity for lanostane-type triterpenoids.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hai-Guo Su, Qian Wang, Lin Zhou, Xing-Rong Peng, Wen-Yong Xiong, Ming -Hua Qiu
Summary: The study identified compounds in Ganoderma applanatum extract that have antiadipogenic effects, with a new compound showing potential in inhibiting adipogenesis. This suggests a new perspective for treating obesity by utilizing these compounds.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Arunrat Yangchum, Ryoma Fujii, Wilunda Choowong, Pranee Rachtawee, Maneerat Pobkwamsuk, Thitiya Boonpratuang, Seiji Mori, Masahiko Isaka
Summary: In the search for medicinally active compounds in Ganoderma mushrooms, eleven previously undescribed lanostane triterpenoids were isolated, including a novel chlorinated derivative. Two of these compounds exhibited moderate antimalarial activity.
Article
Biochemistry & Molecular Biology
Da-Wei Li, Min Liu, Yue-Qi Leng, Jin-Fang Hu, Sa Deng, Ai-Jing Leng, Xiao-Chi Ma, Ruo-Yu Wang, Jian Zhou, Chao Wang
Summary: This study investigated the bioactive phytochemicals in Ganoderma lucidum and found that its triterpenoids showed inhibitory effects on the enzyme FAAH, indicating their potential for treating neuroinflammation.
Article
Food Science & Technology
Jun Lu, Ying Zheng, Zhenyu Yang, Jing Cheng, Feijun Luo
Summary: This study evaluated the phenolic composition and antioxidant properties of K. coccinea fruit epicarp, finding that it is rich in anthocyanins and flavonols. The study also demonstrated the cytoprotective effects of the phenolic extracts, showing their potential as natural antioxidants for developing nutraceuticals and dietary supplements.
Article
Biochemistry & Molecular Biology
Shu-Han Zhang, Jun Wang, Xin-Yue Dong, Gang-Qiang Wang, Tao Feng, Xiao-Jun Li, Ji-Kai Liu
Summary: Eight undescribed lanostane triterpenoids, physivitrins A-H, and four known analogues were isolated from cultures of the fungus Physisporinus vitreus. Their structures were determined using extensive spectroscopic methods, and the absolute configuration of physivitrin A was elucidated through electronic circular dichroism calculation and NMR calculation with DP4+ analysis. Physivitrins B and C showed inhibitory activities against nitric oxide production in LPS-activated RAW264.7 macrophages, with IC50 values of 7.5 and 23.5 μM, respectively. Moreover, physivitrin B significantly inhibited the mRNA expression of proinflammatory cytokines (TNF-α, iNOS, and IL-1β).
Article
Chemistry, Applied
Weixing Huang, Liqin Ding, Nan Zhang, Wei Li, Kazuo Koike, Feng Qiu
Summary: A phytochemical study on the barks of Eucommia ulmoides Oliv. led to the identification of 18 flavonoids, with the new compound eucommiaflavone having its structure elucidated. Five of the flavonoids demonstrated significant hepatoprotective activity against cytotoxicity induced by D-galactosamine in HepG2 cells.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Di Zhou, Yang Li, Gang Chen, Yanqiu Yang, Yan Mi, Bin Lin, Wei Li, Yue Hou, Ning Li
BIOORGANIC CHEMISTRY
(2020)
Article
Plant Sciences
Kouharu Otsuki, Wei Li, Kasumi Miura, Yoshihisa Asada, Li Huang, Chin-Ho Chen, Kuo-Hsiung Lee, Kazuo Koike
JOURNAL OF NATURAL PRODUCTS
(2020)
Article
Chemistry, Medicinal
Mi Zhang, Kouharu Otsuki, Shizuka Kato, Yuito Ikuma, Takashi Kikuchi, Ning Li, Kazuo Koike, Wei Li
Summary: A novel feruloylated acylglycerol derivative was isolated from Wikstroemia pilosa, and its structure was determined through extensive physiochemical and spectroscopic analysis. The contents of the derivative in ten Wikstroemia species were quantitatively analyzed using high-resolution accurate mass LC-MS.
JOURNAL OF NATURAL MEDICINES
(2022)
Article
Plant Sciences
Di Zhou, Fengjiao Zhang, Takashi Kikuchi, Miao Yao, Kouharu Otsuki, Gang Chen, Wei Li, Ning Li
Summary: A phytochemical investigation of Euphorbia helioscopia yielded 27 macrocyclic diterpenoids, including three previously unreported lathyrane derivatives. Three of these compounds exhibited cytotoxicity against a paclitaxel-resistant lung cancer cell line, but showed no activity against the parent cancer cell line. It was observed that compounds with benzoyloxy or nicotinoyloxy substituents at a specific position displayed enhanced cytotoxic activity.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Plant Sciences
Di Zhou, Kouharu Otsuki, Mi Zhang, Gang Chen, Zi-Song Bai, Haotian Yu, Takashi Kikuchi, Li Huang, Chin-Ho Chen, Wei Li, Ning Li
Summary: Tigliane-type diterpenoids have significant biological effects, including antineoplastic and anti-HIV activities. In this study, new tigliane-type diterpenoids were isolated from Wikstroemia lichiangensis for the first time, and their structures were determined. These compounds exhibited potent anti-HIV activity against HIV-1 infection.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Plant Sciences
Yoshihisa Asada, Kouharu Otsuki, Miki Morooka, Li Huang, Chin-Ho Chen, Kazuo Koike, Wei Li
Summary: Edgeworthianins A-E, a class of macrocyclic daphnane orthoesters with an unusual macrocyclic ring structure formed from a C14 aliphatic chain, were isolated from Edgeworthia chrysantha. Compounds 2, 4, and 5 showed potent anti-HIV activity against HIV-1 infection of MT4 cells, with EC50 values of 29.3, 8.4, and 2.9 nM, respectively.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Yan Mi, Jikai Xu, Ruijia Shi, Qingqi Meng, Libin Xu, Yeshu Liu, Tingting Guo, Di Zhou, Jingyu Liu, Wei Li, Ning Li, Yue Hou
Summary: This study investigates the effect of okanin on cognitive impairment following ischemic stroke and finds that it attenuates impairment by inhibiting microglial activation and decreasing NLRP3 inflammasome activation. The study also shows that the miR-7/NLRP3 axis plays a crucial role in mediating the beneficial effects of okanin on cerebral ischemia.
Review
Chemistry, Medicinal
Kouharu Otsuki, Wei Li
Summary: Tigliane and daphnane diterpenoids, found in Thymelaeaceae and Euphorbiaceae plants, have diverse structures due to the presence of polyoxygenated functionalities in their polycyclic skeleton. Despite being known as toxic components, these diterpenoids have shown a wide range of biological activities, including anti-cancer, anti-HIV, and analgesic properties, making them attractive in natural product drug discovery. This review focuses on naturally occurring tigliane and daphnane diterpenoids from Thymelaeaceae plants, providing an overview of their chemical structure, distribution, isolation, structure determination, chemical synthesis, and recent findings.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Biochemistry & Molecular Biology
Kaori Ito, Takashi Kikuchi, Kanako Ikube, Kouharu Otsuki, Kazuo Koike, Wei Li
Summary: A total of 147 oral Kampo prescriptions were evaluated for their anti-glycation activity, and Kakkonto showed significant activity. Analysis of the chemical constituents of Kakkonto revealed the presence of various compounds, and further analysis identified ephedrine as the key component responsible for its anti-glycation activity. The extract of Ephedrae herba, which contains ephedrine, also exhibited strong anti-glycation activity.
Article
Plant Sciences
Yeshu Liu, Yan Mi, Yongping Wang, Qingqi Meng, Libin Xu, Yueyang Liu, Di Zhou, Yingjie Wang, Dong Liang, Wei Li, Ning Li, Yue Hou
Summary: The study showed that Loureirin C has a neuroprotective effect in preventing ischemic stroke by inhibiting ferroptosis through the activation of the Nrf2 pathway and increasing the content of HO-1, NQO1, and GPX4.
Article
Chemistry, Medicinal
Lingjian Tan, Kouharu Otsuki, Mi Zhang, Takashi Kikuchi, Di Zhou, Ning Li, Li Huang, Chin-Ho Chen, Wei Li
Summary: Daphnepedunins G and H with an unusual macrocyclic structure were isolated from Daphne pedunculata. Their structures were determined and their methyl esters showed potent anti-HIV activity.
JOURNAL OF NATURAL MEDICINES
(2023)
Review
Chemistry, Multidisciplinary
Mi-xue Zhao, Jing Cai, Ying Yang, Jian Xu, Wen-yuan Liu, Toshihiro Akihisa, Wei Li, Takashi Kikuchi, Feng Feng, Jie Zhang
Summary: This review provides a detailed description of the botanical properties, traditional uses, chemical compositions, pharmacological activities, and toxicity of the genus Alstonia, analyzing its value in clinical applications.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Plant Sciences
Mi Zhang, Kouharu Otsuki, Reo Takahashi, Takashi Kikuchi, Di Zhou, Ning Li, Wei Li
Summary: Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) is a powerful tool for the rapid identification of compounds within natural resources. This study used LC-MS/MS analysis to investigate the presence of structurally diverse daphnane diterpenoids in Wikstroemia indica, significantly contributing to our understanding of bioactive diterpenoids in plants within the Thymelaeaceae family.
Review
Biochemistry & Molecular Biology
Yuqi Li, Wanfang Zhu, Jing Cai, Wenyuan Liu, Toshihiro Akihisa, Wei Li, Takashi Kikuchi, Jian Xu, Feng Feng, Jie Zhang
Summary: This study discusses the metabolic differences between steviol glycosides and glucosylated steviol glycosides, as well as their molecular mechanisms against diabetes-related metabolic disorders. The results show that they can help regulate physiological functions and may be used as potential alternatives for preventing and treating diabetes.
