期刊
JOURNAL OF NATURAL PRODUCTS
卷 71, 期 5, 页码 881-883出版社
AMER CHEMICAL SOC
DOI: 10.1021/np0706567
关键词
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High-throughput screeing of a plant and marine invertebrate extract library to find natural products with rat thytotropin releasing hormone receptor 2 binding affinity led to the isolation of two new active acylphloroglucinols, corymbones A and B (1 and 2) from flowers of the Queensland tree Corymbia peltata. Their structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. Compounds 1 and 2 showed rat TRH receptor 2 binding affinity with IC(50) values of 23 and 19 mu M, respectively.
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