期刊
JOURNAL OF NATURAL PRODUCTS
卷 71, 期 5, 页码 884-886出版社
AMER CHEMICAL SOC
DOI: 10.1021/np070658r
关键词
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High-throughput screening of a plant and marine invertebrate extract library to find natural products with rat thyrotropin releasing hormorne (TRH) receptor 2 binding affinity led to the isolation of four new (1-4) and one known (5) spongian diterpene from the sponge Spongia sp. The structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. The absolute configurations of 1-4 were proposed on the basis of analysis of their CD spectra. Diterpenes 1-5 showed rat TRH receptor 2 binding affinity with IC(50) values of 23 mu M, 70 mu M, 400 mu M, 600 mu M, and 1 mM, respectively.
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