期刊
JOURNAL OF NATURAL PRODUCTS
卷 71, 期 9, 页码 1625-1629出版社
AMER CHEMICAL SOC
DOI: 10.1021/np8002172
关键词
-
资金
- NOAA
- U.S Department of Commerce [NA06OAR4170014]
- the External User Program of the National High Magnetic Field Laboratory (NHMFL)
- the Advanced Magnetic Resonance Imaging and Spectroscopy (AMRIS)
Two cyclodepsipeptides named kempopeptins A (1) and B (2) were isolated from a collection of a Floridian marine cyanobacterium, Lyngbya sp., that had previously afforded the structurally related potent elastase inhibitors lyngbyastatin 7 and somamide B. The structures of 1 and 2 were elucidated mainly by 1D and 2D NMR spectroscopy, and the absolute configuration was established by chiral HPLC and Marfey's analysis of the degradation products. Kempopeptin A (1) exhibited an IC(50) against elastase of 0.32 mu M and against chymotrypsin of 2.6 mu M, while kempopeptin B (2) inhibited trypsin with an IC(50) of 8.4 mu M.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据