期刊
JOURNAL OF NATURAL MEDICINES
卷 67, 期 3, 页码 643-646出版社
SPRINGER JAPAN KK
DOI: 10.1007/s11418-012-0699-y
关键词
Anti-degranulation; RBL-2H3; Flavanone; Hesperetin; Naringenin
资金
- Antiaging Center Project for Private Universities from the Ministry of Education, Culture, Sports, Science and Technology
The anti-degranulating activity of flavonoids present in Citrus fruits was comprehensively evaluated. Among these, hesperetin and naringenin, respectively aglycones of hesperidin and narirutin, showed significant activity. The targets of hesperetin and naringenin were found: hesperetin inhibited phosphorylation of Syk and Akt, while naringenin suppressed the expression of Lyn and inhibited the phosphorylation of Akt. These results suggest that hesperetin and naringenin inhibit degranulation by suppression of pathway signals and reduce the symptoms of allergy by inhibiting phosphorylation of Akt, which leads to the suppression of cytokines. In addition, hesperetin showed inhibitory activity against the degranulation induced by calcium ionophores, indicating that hesperetin exerts its inhibitory activity by stabilizing the membrane structure.
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