期刊
JOURNAL OF NATURAL MEDICINES
卷 67, 期 3, 页码 460-467出版社
SPRINGER JAPAN KK
DOI: 10.1007/s11418-012-0697-0
关键词
5,7-Dihydroxyflavone; Antiproliferative activity; Apoptosis; Cell differentiation; Human promyelocytic leukemia HL-60 cell
Flavonoids are widely occurring polyphenols that are found in plants. The aim of this study was to investigate the structure-activity relationships of 5,7-dihydroxyflavones, with a focus on the effect of B ring structure substitution on the antiproliferative effects of the compounds in human leukemia HL-60 cells. We prepared a series of 5,7-dihydroxyflavones and evaluated their ability to inhibit the proliferation of HL-60 cells by using the MTT assay. The apoptosis- and cell differentiation-inducing ability of the most potent flavones were investigated using staining and morphological analyses. This study explored the antileukemic and chemopreventive potency of 5,7-dihydroxyflavones, particularly diosmetin and chrysoeriol, which have both hydroxy and methoxy groups on the B ring.
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