Article
Ecology
Karina Atriztan-Hernandez, Alfredo Herrera-Estrella
Summary: The response mechanism of fungi to injury and predators is similar to that of plants and animals, activating specific signaling pathways to initiate defense mechanisms. Attack by fruit flies can inhibit fungal regeneration and immune defense, possibly involving components of fruit fly salivary glands.
Article
Chemistry, Medicinal
Kai-Liang Ma, Shi-Hui Dong, Hang-Ying Li, Wen-Jun Wei, Yong-Qiang Tu, Kun Gao
Summary: Three new cytochalasins were isolated from an endophytic fungus of Cephalotaxus fortunei, showing significant inhibitory activity against the interaction of LAG3/MHC II and LAG3/FGL1, indicating potential biological activities.
NATURAL PRODUCTS AND BIOPROSPECTING
(2021)
Article
Chemistry, Medicinal
Jialin Li, Tao Chen, Jianchen Yu, Hao Jia, Chen Chen, Yuhua Long
Summary: Three new dimeric sorbicillinoids (1-3) and one new 3,4,6-trisubstituted alpha-pyrone (5), along with seven analogues (4 and 6-11), were isolated from the mangrove endophytic fungus Trichoderma reesei SCNU-F0042 under the guidance of molecular networking approach. Their chemical structures were established by 1D and 2D NMR HR-ESI-MS and ECD analysis. In a bioassay, compound 2 exhibited moderate SARS-CoV-2 inhibitory activity with an EC50 value of 29.0 μM.
Article
Chemistry, Applied
Xi-Xiang Tang, Shun-Zhi Liu, Yu-Ying Sun, Feng-Ming He, Guang-Xin Xu, Mei-Juan Fang, Wu Zhen, Ying-Kun Qiu
Summary: Three new cyclopentenoneacrylic acid derivatives were isolated from Trichoderma atroviride H548, with trichodermester A showing potent antifungal activity against Pestalotiopsis theae. The other compounds tested were inactive against the same fungus.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Hua Xu, Yandan Wang, Yiren Zhang, Qiaoming Lou, Xiupeng Guan, Jun Jin, Qingzhe Jin, Xingguo Wang
Summary: In this study, the characteristics and digestion properties of Cephalotaxus fortunei kernel oil were investigated. The results showed that the oil content of C. fortunei kernels was high (64.59%) and mostly composed of triacylglycerols (TAGs). The oil was rich in oleic acid, linoleic acid, and sciadonic acid, as well as tocopherols and phytosterols. In vitro digestion experiments revealed a lower release level of free fatty acids from the kernel oil compared to soybean oil.
Article
Chemistry, Multidisciplinary
Zhan-Peng Ge, Bin Zhou, Flavia M. Zimbres, Maria B. Cassera, Jin-Xin Zhao, Jian-Min Yue
Summary: A chemical investigation of the seeds of Cephalotaxus fortunei var. alpina led to the discovery of new cephalotane-type norditerpenoids and their structures were determined. Two of these compounds exhibited moderate antimalarial activity.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Organic
Zhan-Peng Ge, Bin Zhou, Flavia M. Zimbres, Reagan S. Haney, Qun-Fang Liu, Yan Wu, Maria B. Cassera, Jin-Xin Zhao, Jian-Min Yue
Summary: Seventeen new cephalotane-type diterpenoids were isolated from the seeds of Cephalotaxus fortunei var. alpina. Their structures were determined and some of them exhibited unusual features not found in cephalotane-type diterpenoids before. The compounds were also evaluated for their antiplasmodial activity.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Yihao Yin, Qi Tan, Jianying Wu, Tao Chen, Wencong Yang, Zhigang She, Bo Wang
Summary: Five new polyketides, along with five known polyketides, were isolated from mangrove endophytic fungus Trichoderma lentiforme ML-P8-2. The structures were determined using NMR, MS, and other techniques. Compound 6 and 9 exhibited promising antifungal activities against Penicillium italicum, while compound 3 displayed moderate AChE inhibitory activity.
Article
Chemistry, Applied
Xiu-Li Yin, Yin-Ping Song, Xiang-Hong Liu, Nai-Yun Ji
Summary: A new cyclopentenone derivative, 4-hydroxyhypocrenone A, and a new naturally-occurring wickerol derivative, 8-acetoxywickerol A, as well as two known compounds, hypocrenone A and wickerol B, were isolated from the endophytic fungus Trichoderma atroviride A-YMD-9-4, which was obtained from the marine red alga Gracilaria verrucosa. The structures and relative configurations of the new isolates were determined using various spectroscopic methods, and the absolute configuration of one compound was assigned through quantum chemical calculations. Compounds 1 and 2 showed weak inhibitory activity against one or two marine phytoplankton species.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Organic
Li Zhu, Dong-Rong Zhu, Wu-Xi Zhou, Jiang-Min Zhu, Li-Jie Gong, Yin Li, Ling-Yi Kong, Jian-Guang Luo
Summary: Fortuneicyclidins A and B, newly isolated pyrrolizidine alkaloids from the seeds of Cephalotaxus fortunei, contain a unique core structure and one of them exhibited inhibitory activity against alpha-glucosidase.
Article
Biochemistry & Molecular Biology
Yong-Liang Wang, Bin-Yuan Hu, Meng-An Qian, Zi-Hang Wang, Jing-Mei Zou, Xu-Yan Sang, Lei Li, Xiao-Dong Luo, Li-Xing Zhao
Summary: In this study, a new compound named koninginin W (1) and four known polyketides (2-5) were isolated from the endophytic fungus Trichoderma koningiopsis YIM PH30002 of Panax notoginseng. The structures of 1 - 5 were elucidated through detailed analysis of HR-ESI-MS, 1D and 2D NMR, and X-ray crystallographic data, including the absolute configuration of 1. Koninginin W (1) showed weak antibacterial activity against Escherichia coli, Bacillus subtilis, and Salmonella typhimurium.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Plant Sciences
Xiang-Hong Liu, Yin-Ping Song, Bin-Gui Wang, Nai-Yun Ji
Summary: In this study, two new bisabolane derivatives and two new lauric acid derivatives were isolated from the marine-alga-endophytic Trichoderma atroviride RR-dl-3 9. The two lauric acid derivatives showed antibacterial activities against marine-derived bacteria.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Li Zhu, Li-Jie Gong, Dong-Rong Zhu, Jiang-Min Zhu, Yin Li, Ling-Yi Kong, Jian-Guang Luo
Summary: Six new Cephalotaxus alkaloids, including a unique cephalotaxine-type alkaloid, were isolated from the seeds of Cephalotaxus fortunei. Among them, one alkaloid showed moderate cytotoxic activity against HCT-116 cell line.
Article
Biochemistry & Molecular Biology
Wei Yan, Wenxia Ji, Chuan Ping, Tianyi Zhang, Yu Li, Biao Wang, Tianyu Chen, Bo He, Yonghao Ye
Summary: This study isolated a new compound (+/-)-trichodermatrione A from the endophytic fungus Trichoderma sp. EFT2 in Euonymus fortunei. The compound showed antibacterial activity against phytopathogenic bacteria Xanthomonas oryzae pv. oryzae (Xoo) and X. oryzae pv. oryzicola (Xoc).
Article
Chemistry, Organic
Chun-Xue Zhao, Hui Liu, Xin Zhang, Meng-Yue Yang, Yue-Tong Wang, Yi-Jia Xing, Jun-Xin Hua, Qin Zhang, Da-Hong Li, Jiao Bai, Yong-Kui Jing, Hui-Ming Hua
Summary: In this study, a range of new alkaloid compounds were isolated from Cephalotaxus fortunei, and their inhibitory effects on leukemia cells were evaluated in vitro.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Cheng-Jian Zheng, Edward Kalkreuter, Bo-Yi Fan, Yu-Chen Liu, Liao-Bin Dong, Ben Shen
Summary: This study presents a detailed investigation of PtmC, an unusual NAT homologue involved in the biosynthesis of thioplatensimycin and related compounds, highlighting its unique role and evolution from canonical NAT scaffold. The findings expand our understanding of enzyme evolution for substrate diversity and provide insights into the activities of NATs in natural product biosynthesis and xenobiotic detoxification.
ACS CHEMICAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Mingming Cao, Chengjian Zheng, Dong Yang, Edward Kalkreuter, Ajeeth Adhikari, Yu-Chen Liu, Mostafa E. Rateb, Ben Shen
Summary: Through a series of in vitro and in vivo experiments, it has been shown that the conversion of TACs may result from two non-enzymatic steps, possibly mediated by endogenous hydrogen sulfide. Therefore, TACs are proposed to derive from a detoxification process.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Medicinal
Jiacheng Ji, Chang Liu, Xuhui He, Guilin Chen, Luping Qin, Chengjian Zheng
Summary: Two new 19,20-seco-chaetoglobosins, salchaetoglobosins A and B, along with three known analogues, were isolated from the solid rice culture of Chaetomium globosum D38, an endophytic fungus derived from Salvia miltiorrhiza, and their structures and biological activities were evaluated.
Article
Biochemistry & Molecular Biology
Yanbin Wu, Chang Liu, Yingqian Jiang, Bingke Bai, Xuhui He, Hongrui Wang, Jinzhong Wu, Chengjian Zheng
Summary: In this study, two new polysaccharides, AZP-1a and AZP-1d, were extracted from Anoectochilus zhejiangensis and their structural characteristics were explored. The results showed that A. zhejiangensis polysaccharides exhibited significant hepatoprotective effects and AZP-1a and AZP-1d mainly functioned through the activation of the Nrf2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Neurosciences
Zu-Cheng Shen, Zhi-Xuan Xia, Jian-Min Liu, Jie-Yan Zheng, Yu-Fei Luo, Han Yang, Meng-Die Li, Ting Cao, Hai-Ping Liu, Gui-Lin Jin, Hui-Hui Huang, Chang-Xi Yu, Jun Zhou
Summary: Palmitoylation has been found to be relevant to learning, memory, and disorders such as post-traumatic stress disorder and aging-related cognitive decline. However, the mechanisms underlying palmitoylation in these processes are not well understood. This study investigated the role of palmitoylation in hippocampal synaptic transmission and fear memory formation and identified the involvement of APT1-mediated depalmitoylation in the regulation of glutamatergic synaptic plasticity.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Wan Gong, Mengqin Liu, Qi Zhang, Quanlong Zhang, Yang Wang, Qiming Zhao, Lu Xiang, Chengjian Zheng, Qiaoyan Zhang, Luping Qin
Summary: The phenolic glycoside orcinol glucoside (OG) was found to attenuate bone loss in mice with senile osteoporosis by activating the Nrf2/Keap1 and mTOR signaling pathways. It inhibited the formation, differentiation, and bone resorption activities of osteoclasts, as well as reduced oxidative stress and autophagy levels.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Pharmacology & Pharmacy
GuiLin Jin, Zhen Luo, Mingke Fen, Lijun Xu
Summary: Peiminine regulates the P13K/Akt/mTOR and oxidative stress pathways to suppress the proliferative, apoptotic and migratory potential of colorectal carcinoma HCT-116 cells.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Bingke Bai, Chang Liu, Chengzhong Zhang, Xuhui He, Hongrui Wang, Wei Peng, Chengjian Zheng
Summary: This review summarizes the structural diversities, biological activities, and promising biosynthetic potentials of terpenoids isolated from Trichoderma species. Trichoderma terpenoids exhibit important antibacterial, antifungal, inhibitory, and cytotoxic activities, making Trichoderma species valuable microbial resources for drug discovery and environmentally friendly agrochemicals development. The abundance of novel skeletons, bioactivities, and biosynthetic potentials present new opportunities for drug and agrochemicals discovery, genome mining, and enzymology exploration from Trichoderma species.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yi Shi, Xuhui He, Bingke Bai, Hongrui Wang, Chang Liu, Liming Xue, Jinzhong Wu, Yanbin Wu, Chengjian Zheng
Summary: Anoectochilus elatus, a new species discovered in Yunnan, China, has been traditionally used for medicinal and culinary purposes. The crude polysaccharide of Anoectochilus elatus (AEP) showed significant antinociceptive effects in vivo, with GJXL-1 identified as the leading analgesic polysaccharide in AEP.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Organic
Mingming Cao, Dong Yang, Ajeeth Adhikari, Fei Ye, Chengjian Zheng, Wei Yan, Song Meng, Ping Su, Ben Shen
Summary: The authors isolated neogrisemycin (1) from a recombinant Streptomyces albus J1074 strain SB4061 expressing an engineered thioangucycline (TAC) biosynthetic gene cluster (BGC). They determined the structure and absolute configuration of 1 using mass spectrometry, nuclear magnetic resonance, and single-crystal X-ray diffraction analyses. They proposed that 1, like the TACs, is derived non-enzymatically from the common epoxide (8) encoded by the tac BGC, mediated by endogenous hydrogen trisulfide.
Correction
Plant Sciences
Gui-lin Jin, Hai-ping Liu, Ya-xin Huang, Qing-quan Zeng, Jin-xing Chen, Xiao-bing Lan, Zhi-ming Xin, Bo-jun Xiong, Rong-cai Yue, Chang-xi Yu
Article
Plant Sciences
Gui-lin Jin, Hai-ping Liu, Ya-xin Huang, Qing-quan Zeng, Jin-xing Chen, Xiao-bing Lan, Zhi-ming Xin, Bo -jun Xiong, Rong-cai Yue, Chang-xi Yu
Summary: This study revealed the critical role of TSPO in sepsis-associated liver injury by regulating the polarization of liver macrophages and reducing the inflammatory response. KM, as a TSPO ligand, showed potential as a desirable candidate for the treatment of SALI and may exert its effect by regulating the M1/M2 polarization of macrophages in the liver.
Article
Chemistry, Medicinal
Yanfei Ban, Yang Wang, Liming Qiao, Chengzhong Zhang, Hongrui Wang, Xuhui He, Dan Jia, Chengjian Zheng
Summary: This study investigated the anti-osteoarthritis effects of the total lignans of Vitex negundo seeds (TOV) in osteoarthritis rats, as well as the effects of its main components VN1 and VN2 on osteoclast differentiation. TOV significantly alleviated osteoarthritis symptoms and decreased inflammatory markers. VN2 inhibited osteoclast differentiation by suppressing ERK/NFATc1 signaling and actin ring formation. These findings suggest that TOV has therapeutic potential for osteoarthritis treatment and VN2 plays a key role in its efficacy.
PHYTOTHERAPY RESEARCH
(2023)
Correction
Biochemistry & Molecular Biology
Yanbin Wu, Chang Liu, Yingqian Jiang, Bingke Bai, Xuhui He, Hongrui Wang, Jinzhong Wu, Chengjian Zheng
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Microbiology
Xing-Guang Xie, Wei-Lan Lu, Kun-Miao Feng, Cheng-Jian Zheng, Yang Yang, Min Jia, Yi-Sang Wu, Yan-Zhang Shi, Ting Han, Lu-Ping Qin
Summary: Endophytic fungi, such as Epichloe bromicola, have been found to enhance plant growth and biosynthesis of secondary metabolites. In this study, the growth-promoting effects of E. bromicola on Arabidopsis thaliana seedlings were observed, and it was found that the compound IAA and 2,3-butanediol were responsible for the effects. Furthermore, the expression of IAA-related genes was upregulated after inoculation with E. bromicola, indicating the involvement of IAA in the growth-promoting mechanism.
CURRENT MICROBIOLOGY
(2023)
