期刊
JOURNAL OF NATURAL MEDICINES
卷 66, 期 1, 页码 222-226出版社
SPRINGER JAPAN KK
DOI: 10.1007/s11418-011-0565-3
关键词
Aspergillus fumigatus; Indole alkaloids; 2-(3,3-Dimethylprop-1-ene)-costaclavine; 2-(3,3-Dimethylprop-1-ene)-epicostaclavine; Stereochemistry
资金
- University of Tokyo
Two new indole alkaloids, 2-(3,3-dimethylprop-1-ene)-costaclavine (1) and 2-(3,3-dimethylprop-1-ene)-epicostaclavine (2), together with the known compounds costaclavine (3), fumgaclavine A (4) and C (5), were isolated from the marine-derived fungus Aspergillus fumigatus. The planar structures of the two new compounds were elucidated on the basis of chemical and physicochemical evidence including MS, UV, IR and NMR spectra. Their stereochemistry was studied by NOESY, H-1-H-1 coupling constant and CD spectra. The compounds 1, 2, 3 and 5 showed weak cytotoxicity against a mouse leukemia cell line (P388).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据