Article
Polymer Science
Andres Ortega-Garcia, Bryan Giovanny Martinez-Bernal, Israel Ceja, Eduardo Mendizabal, Jorge Emilio Puig-Arevalo, Lourdes Adriana Perez-Carrillo
Summary: This paper reports the synthesis of stimulus-responsive polymer nanohydrogels with a core/shell structure using batch emulsion polymerization in the presence of chitosan micelles. The nanohydrogels were loaded with the drug doxycycline hyclate and showed a higher release amount at acidic pH. Mathematical models were used to fit the experimental drug release data.
Article
Polymer Science
Yi-Cheng Huang, Yang-Jie Zeng, Yu-Wei Lin, Hung-Chih Tai, Trong-Ming Don
Summary: A dual pH/thermo-responsive block copolymer was synthesized and used to encapsulate the anticancer drug CPT. The drug carrier showed stable particle size and charge, good biocompatibility with cells, and controlled release and cellular uptake of CPT based on environmental conditions. It exhibited high cytotoxicity against H460 cancer cells, suggesting its potential application in oral administration.
Review
Pharmacology & Pharmacy
Lorenzo Marsili, Michele Dal Bo, Federico Berti, Giuseppe Toffoli
Summary: Microgels are soft, porous, and deformable particles with an internal gel structure that are swollen by a solvent, making them potential candidates for drug delivery systems. Recent advancements in biodegradable polymer fabrication have led to new strategies in combining synthetic and natural-origin polymers with inorganic nanoparticles for controlled drug release. The use of chitosan-grafted-poly-(N-vinylcaprolactam) microgels in drug delivery and oncology applications is reviewed in this study.
Article
Polymer Science
Migle Babelyte, Laura Peciulyte, Vesta Navikaite-Snipaitiene, Joana Bendoraitiene, Volodymyr Samaryk, Ramune Rutkaite
Summary: Thermoresponsive chitosan-graft-poly(N-isopropylacrylamide) copolymers with different compositions were synthesized. The chemical structure of the copolymers was confirmed and their lower critical solution temperature (LCST) behavior was assessed. Copolymers with a certain content of poly(N-isopropylacrylamide) side chains demonstrated LCST behavior and could potentially be used in drug delivery systems or tissue engineering.
Article
Polymer Science
Giacomo Damonte, Martina Cozzani, Donatella Di Lisa, Laura Pastorino, Alberto Mariani, Orietta Monticelli
Summary: The aim of this study was to improve the properties of hydrogels based on PNIPAAm by combining it with a synthesized star-shaped PCL. The addition of PCL-COOH increased the stiffness of the hydrogels and affected the glass transition temperature. The hydrogels showed good biocompatibility and low cytotoxicity.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Jiaxin Sun, Yongjing Li, Xiuli Wang, Weiwei Fei, Jia Guo, Changchun Wang
Summary: This study developed a new protein-functionalized targeting nanodrug preparation strategy, which involves quick loading of different proteins into polyacrylic acid nanohydrogels and achieving excellent tumor targeting effects through oriented binding of targeting agents.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Yiluo Hu, Younghyun Shin, Sohyun Park, Jae-pil Jeong, Yohan Kim, Seunho Jung
Summary: Self-healing and temperature/pH-responsive hydrogels were prepared by using oxidized succinoglycan (OSG) and a poly (N-isopropyl acrylamide-co-acrylamide) [P(NIPAM-AM)] copolymer. OSG, synthesized from succinoglycan (SG) isolated directly from soil microorganisms, showed improved elasticity, thermal stability, self-healing ability, and tensile strength compared to P(NIPAM-AM) hydrogels. The OSG/P(NIPAM-AM) hydrogels also exhibited effective temperature/pH-responsive drug release and non-toxicity, suggesting their potential for biomedical applications such as drug delivery systems, wound healing, scaffolds, and tissue engineering.
Article
Chemistry, Applied
Maja D. Markovic, Vesna V. Panic, Sanja Savic, Vukasin Dj Ugrinovic, Rada Pjanovic, Milica M. Spasojevic, Pavle M. Spasojevic
Summary: Materials sensitive to external stimuli are considered safe and effective tools in responding to specific demands in disease therapy. Thermo sensitive hydrogels based on poly(N-isopropylacrylamide) (P(NIPAAM)) have been extensively studied for targeted drug delivery. However, the abundance of stimuli in the human body often requires multiple responsive groups to act simultaneously for optimal therapeutic effects.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Environmental Sciences
Ye -Lim Han, Hye-Ran Kim, Hyun-Kyung Kim, Jae -Woo Park
Summary: A series of thermosensitive and magneto-responsive dendrimers were synthesized and their properties at different temperatures were studied. The results showed that PNIPAM-g-MCD could encapsulate and fix benzene molecules below the critical solution temperature, while it could disrupt oil-water emulsions above the critical solution temperature.
Article
Chemistry, Multidisciplinary
Gangfeng Jiang, Nannan Wang, Lina Jia, Hongli Che, Lihui Wang, Jingyu Yang, Hui Xu, Chunfu Wu, Mingzhe Liu
Summary: The study successfully prepared DNA-conjugated nanohydrogels using copolymerization and hybridization methods, demonstrating their potential application in cancer cell targeted therapy.
NEW JOURNAL OF CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Subhash Chander, Giriraj T. Kulkarni, Neerupma Dhiman, Harsha Kharkwal
Summary: Hydrogels are polymer materials with a unique network structure capable of absorbing water and biological fluids. Nanohydrogels, composed of diverse synthetic or natural polymers, possess high biocompatibility and metabolic degradability. Protein nanohydrogels, with various preparation methods and broad applications in medicine, offer potential in diverse disciplines.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Physical
Ritu Yadav, Sumit Kumar, Payal Narang, Pannuru Venkatesu
Summary: This study investigates the interaction between gold nanoparticles and thermoresponsive polymers, revealing that the shape and morphology of gold nanorods and nanospheres have a significant impact on the conformation of the polymer. The findings have important implications for biomedical science, particularly in drug delivery and tissue engineering, as the polymer behavior approaches human body temperature.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Mohzibudin Z. Quazi, Nokyoung Park
Summary: In the era of nanotechnology, the synthesis of nanomaterials has greatly influenced advanced applications. Polymeric nanomaterials play an important role in molecular science and are widely used in the construction of advanced therapeutics. The use of nanohydrogels has shown promise in biomedical applications and offers constructive strategies for controlled biological applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Min Liu, Jingling Zhu, Xia Song, Yuting Wen, Jun Li
Summary: Smart hydrogels capable of responding to temperature and pH changes were prepared by synthesizing alginate-graft-poly(N-isopropylacrylamide) (Alg-g-PNIPAAm) copolymers and forming polyelectrolyte complexes (PEC) with chitosan. These hydrogels exhibited controlled drug release properties.
Article
Polymer Science
Yu Wang, Kun Yuan, Zhanhao Shang, Guozhu Tan, Qinjie Zhong, Yuejian He, Guifeng Miao, Keren Lai, Yuling Li, Xiaorui Wang
Summary: A novel supramolecular recognition assisted nanohydrogel drug delivery platform was designed and constructed, which showed general loading capability for a wide variety of small molecular hydrophilic and hydrophobic drugs. The results demonstrated that the supramolecular interactions endowed the nanohydrogels with higher drug loading efficiency and controlled release ability, and the nanohydrogel with wrinkled surface morphology enhanced tumor cell uptake and nuclear drug delivery. The improved anti-tumor efficacy was demonstrated in both in vitro and in vivo models. This work broadens the construction strategy of nanohydrogels and provides a general delivery platform for efficient tumor chemotherapy.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Materials Science, Biomaterials
Thanigaivel Shanmugam, Nitin Joshi, Anubhav Kaviratna, Nadim Ahamad, Eshant Bhatia, Rinti Banerjee
Summary: This study demonstrates a noninvasive approach for delivering PTX to deep pulmonary tissues via an inhalable nanocochleate platform, showing its potential in treating pulmonary metastasis of melanoma cancer.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Arpan Pradhan, Satyendra Mishra, Avadhesha Surolia, Dulal Panda
Summary: C1, a synthetic derivative of curcumin, strongly inhibits the aggregation and filament formation of tau, protects neuroblastoma cells from the deleterious effects of tau oligomers, and reduces the mean diameter and quantity of tau oligomers.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Engineering, Biomedical
Nadim Ahamad, Abhinanda Kar, Sourabh Mehta, Mahima Dewani, Vasanthan Ravichandran, Prateek Bhardwaj, Shivam Sharma, Rinti Banerjee
Summary: Inflammatory diseases encompass various illnesses with chronic inflammation as the central manifestation, posing a significant burden on healthcare systems and global socio-economic balance. Current standard therapies are limited in providing relief, whereas immunomodulatory nanosystems present new opportunities for treating inflammatory diseases.
Article
Chemistry, Physical
Sushanth Gudlur, Garima Goyal, Arpan Pradhan, James C. S. Ho, Rohit Srivastava, Bo Liedberg
Summary: This study demonstrates the liposome-directed anisotropic growth of gold nanorods synthesized without surfactants, resulting in biocompatible GNRs. The synthesized phospholipid-passivated GNRs exhibit stability, excellent biocompatibility, and photothermal transduction ability, making them suitable for plasmonic photothermal therapy in biological applications.
CHEMISTRY OF MATERIALS
(2021)
Article
Biophysics
Arpan Pradhan, Satyendra Mishra, Suparna Mercy Basu, Avadhesha Surolia, Jyotsnendu Giri, Rohit Srivastava, Dulal Panda
Summary: A lipid nanoparticle formulation of C1 targeting the folate receptor has shown strong anticancer activity against cancer cells and cancer stem cells by inducing apoptosis and inhibiting proliferation through various mechanisms.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Nanoscience & Nanotechnology
Eshant Bhatia, Durga Kumari, Shivam Sharma, Nadim Ahamad, Rinti Banerjee
Summary: Skin aging is a continuous process influenced by intrinsic and extrinsic factors. Nanoparticles are considered a powerful tool in the cosmeceutical industry for enhancing the efficacy of antiaging agents and protecting the skin against external factors.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Puja Sandbhor, Jayant Goda, Bhabani Mohanty, Pradip Chaudhari, Shilpee Dutt, Rinti Banerjee
Summary: The study suggests that targeted nanovesicles delivered through the intranasal route have the potential to bypass the blood-brain barrier, significantly increase brain drug bioavailability, and achieve better therapeutic outcomes in the treatment of glioblastoma.
Review
Materials Science, Biomaterials
Survanshu Saxena, Kapil Punjabi, Nadim Ahamad, Subhasini Singh, Prachi Bendale, Rinti Banerjee
Summary: Antimicrobial resistance (AMR) is a major global health concern, and nanotechnology approaches offer simpler, faster, and more affordable solutions for AMR diagnostics. However, several bottlenecks need to be addressed before these approaches can be translated to clinics.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Biochemical Research Methods
Kapil Punjabi, Rishi Rajat Adhikary, Aishani Patnaik, Prachi Bendale, Survanshu Saxena, Rinti Banerjee
Summary: This study developed a point-of-care technology using crystal violet entrapped, lectin functionalized chitosan nanoparticles to detect clinically relevant bacterial infections. The device does not require sample preparation or sophisticated instruments, and can rapidly differentiate between bacterial and nonbacterial infections within 10 minutes.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Materials Science, Biomaterials
Kapil Punjabi, Eshant Bhatia, Roshan Keshari, Kiran Jadhav, Subhasini Singh, Jayanti Shastri, Rinti Banerjee
Summary: The global pandemic of COVID-19 and emerging antimicrobial drug resistance emphasizes the need for sustainable technology for preparedness and control measures. We have developed a biocompatible and biodegradable nanoemulsion coating for textiles, specifically cotton fabric, with broad spectrum antimicrobial, antibiofilm, and anti-SARS-CoV-2 activity. The coated fabric exhibits superior barrier properties and filtration efficiency compared to an N95 respirator. The strategy provides a long-term sustainable alternative to single-use masks and PPE, which contribute to nondegradable waste accumulation.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Immunology
Elise G. Viox, Timothy N. Hoang, Amit A. Upadhyay, Rayhane Nchioua, Maximilian Hirschenberger, Zachary Strongin, Gregory K. Tharp, Maria Pino, Kevin Nguyen, Justin L. Harper, Matthew Gagne, Shir Marciano, Arun K. Boddapati, Kathryn L. Pellegrini, Arpan Pradhan, Jennifer Tisoncik-Go, Leanne S. Whitmore, Kirti A. Karunakaran, Melissa Roy, Shannon Kirejczyk, Elizabeth H. Curran, Chelsea Wallace, Jennifer S. Wood, Fawn Connor-Stroud, Emily A. Voigt, Christopher M. Monaco, David E. Gordon, Sudhir P. Kasturi, Rebecca D. Levit, Michael Gale, Thomas H. Vanderford, Guido Silvestri, Kathleen Busman-Sahay, Jacob D. Estes, Monica Vaccari, Daniel C. Douek, Konstantin M. J. Sparrer, R. Paul Johnson, Frank Kirchhoff, Gideon Schreiber, Steven E. Bosinger, Mirko Paiardini
Summary: By modulating IFN-I signaling in rhesus macaques infected with SARS-CoV-2, it was found that controlling IFN-I signaling can reduce viral loads and inflammation, and attenuate the pathogenesis of the virus.
SCIENCE IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Puja Sandbhor, Jayant S. Goda, Bhabani Mohanty, Pradip Chaudhari, Shilpee Dutt, Rinti Banerjee
Summary: A minimally invasive hydrogel implant has been developed for the treatment of glioblastoma, using transferrin-targeted nanovesicles in the surgically resected tumor cavity. The controlled release of drugs from the hydrogel system improves drug penetration and enhances the efficacy of adjuvant therapy.
Article
Chemistry, Multidisciplinary
Tejaswini Appidi, P. S. Rajalakshmi, Shubham A. Chinchulkar, Arpan Pradhan, Hajira Begum, Veeresh Shetty, Rohit Srivastava, Prabhusankar Ganesan, Aravind Kumar Rengan
Summary: This study reports on the synthesis of a hybrid lipo-polymeric nanosystem and demonstrates its ability to encapsulate both hydrophilic and hydrophobic molecules, as well as its enhanced cellular uptake. The nanosystem, surface coated with gold, exhibits a photothermal effect, triggering the production of intracellular ROS, DNA damage, and apoptotic cell death. Additionally, the surface-enhanced fluorescence of the nanosystem enables its application in cancer cell and zebrafish embryo imaging, as well as effective photothermal therapy against breast cancer.
Article
Chemistry, Multidisciplinary
Prateek Bhardwaj, Jayant Sastri Goda, Venkatesh Pai, Pradip Chaudhari, Bhabani Mohanty, Trupti Pai, Komal Vishwakarma, Rahul Thorat, Tabassum Wadasadawala, Rinti Banerjee
Summary: The study demonstrated the potential of using a nano-conjugate platform for the delivery of curcumin in TNBC treatment, with enhanced efficacy when combined with ultrasound. This approach showed improved safety and therapeutic effects in experiments, indicating broad chemo-radiotherapeutic potential for radio-responsive solid tumors and metastatic niches.
Article
Nanoscience & Nanotechnology
Deepika Singh, Priya Singh, Arpan Pradhan, Rohit Srivastava, Sanjeeb Kumar Sahoo
Summary: This study presents a novel strategy for breast cancer therapy by co-delivering forskolin and paclitaxel in liquid crystal nanoparticles, effectively targeting both cancer stem-like cells and bulk tumor cells, which enhances treatment efficacy.
ACS APPLIED BIO MATERIALS
(2021)