期刊
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷 14, 期 7, 页码 4719-4732出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2014.9503
关键词
Graphene; Graphene Oxide (GO); Mass Spectrometry (MS); Matrix-Assisted Laser Desorption/Ionization (MALDI); Surface-Enhanced Laser Desorption/Ionization (SELDI); Solid-Phase Extraction (SPE); Gas Chromatography; Liquid Chromatography; Carbon Cluster Ions
类别
资金
- National Natural Science Foundation of China [21172121, 21121002, 21374050]
This paper reviews the up-to-date research about the applications of graphene and its related materials in the field of mass spectrometry (MS). Due to its large surface area, delocalized pi-electrons, thermal conductivity, stability and rich interaction chemistry, graphene has been widely used in MS-based analytical chemistry. Graphene-based materials were applied as very effective matrixes or surfaces for many kinds of organic molecules in laser desorption/ionization (LDI) MS analysis. Many advantages of this novel matrix have been proved, which included: low interference ions from matrix itself, good reproducibility, high salt tolerance and so on. The unique properties of graphene also make it a superior sorbent used in solid-phase extraction (SPE). Further development of online SPE methods based on graphene coupling directly with LDI-MS, GC-MS and LC-MS greatly simplifies the MS-based analytical procedure for complex samples and makes the corresponding high-throughput and automatic analysis performable. Their applications as a platform in proteolysis for the rapid identification of proteins have been also developed. In addition, graphene was found to be a unique precursor for the generation of large-sized carbon cluster anions in the gas phase. Finally, the possible challenges and future perspectives in their applications in MS are discussed too.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据