Article
Pharmacology & Pharmacy
Damir Vukoja, Josipa Vlainic, Vanja Ljolic Bilic, Lela Martinaga, Iva Rezic, Diana Brlek Gorski, Ivan Kosalec
Summary: The growing number of drug-resistant infections is a major global health issue, and finding new approaches to combat antimicrobial resistance is essential. This study found that commercially purchased colloidal platinum nanoparticles have strong antibacterial effects against both standard laboratory and drug-resistant strains of E. coli and K. pneumoniae. The mechanisms of action for these antibacterial effects involve damage to bacterial cell walls and the induction of reactive oxygen species. Further research is needed to fully understand these mechanisms.
Review
Chemistry, Multidisciplinary
Mohammad Okkeh, Nora Bloise, Elisa Restivo, Lorenzo De Vita, Piersandro Pallavicini, Livia Visai
Summary: Bacterial resistance is escalating, hindering pharma companies from investing in new antibiotic entities to combat the global challenge. Medical nanotechnology utilizing inorganic nanomaterials like gold and silver show potential antibacterial efficacies, with gold nanoparticles gaining specific attention due to their biocompatibility and optical properties.
Article
Infectious Diseases
Lenka Doubravska, Miroslava Htoutou Sedlakova, Katerina Fiserova, Vendula Pudova, Karel Urbanek, Jana Petrzelova, Magdalena Roderova, Katerina Langova, Kristyna Mezerova, Pavla Kucova, Karel Axmann, Milan Kolar
Summary: This observational retrospective study analyzed the changes in bacterial pathogens and their resistance to antibiotics among intensive care patients in a Czech hospital during the COVID-19 pandemic. The study found that there were shifts in the distribution and resistance of bacterial pathogens, possibly due to antibiotic selection pressure and clonal spread of bacteria.
Article
Chemistry, Multidisciplinary
William Ndugire, Dang Truong, N. G. Hasitha Raviranga, Jingzhe Lao, Olof Ramstrom, Mingdi Yan
Summary: The addition of thiourea (TU) enhances the broad-spectrum antimicrobial activity of D-maltose-capped gold nanoclusters (AuNC-Mal). AuNC-Mal/TU exhibits effective inhibition against multidrug-resistant Pseudomonas aeruginosa with low cytotoxicity. The antimicrobial activity is attributed to the generation of [Au(TU)(2)](+) and smaller AuNCs, increased accumulation of Au in bacteria, and inhibition of thioredoxin reductase.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Public, Environmental & Occupational Health
Hak-Jae Kim, Sae Won Na, Hissah Abdulrahman Alodaini, Munirah Abdullah Al-Dosary, P. Nandhakumari, L. Dyona
Summary: The study revealed a high prevalence of antibiotic resistance among bacterial strains isolated from wound infections, with some showing sensitivity to vancomycin. Specifically, Enterococcus faecalis and Proteus species exhibited resistance to various antibiotics.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Review
Chemistry, Multidisciplinary
Lide Arana, Lucia Gallego, Itziar Alkorta
Summary: Solid lipid nanoparticles show promise as a drug delivery system to improve antibiotic characteristics and increase treatment efficiency in the face of antimicrobial resistance. By analyzing the role and advantages of SLNs, as well as their potential drawbacks, this review helps to better understand the application of these new formulations in tackling antibiotic resistance.
Review
Multidisciplinary Sciences
Nada H. Aljarba, Shah Imtiaz, Naushad Anwar, Ibtesam S. Alanazi, Saad Alkahtani
Summary: According to WHO reports, antibiotic resistance and the lack of novel and effective anticancer and antimicrobial chemotherapeutics are major concerns for human health. Gold nanoparticles (Au-NPs) synthesized from natural or chemical sources show potential biological properties against drug-resistant microbial infections and cancer cells. This review provides an overview of the applications of Au-NPs in biomedical research as therapeutic agents, highlighting their antibacterial and anticancer activities and discussing their future prospects.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Khatereh Khorsandi, Saeedeh Keyvani-Ghamsari, Fedora Khatibi Shahidi, Reza Hosseinzadeh, Simab Kanwal
Summary: Bacterial infections are a major cause of mortality worldwide due to the prevalence of drug resistant bacteria. Nanoparticles (NPs) offer a new and alternative approach to combat multidrug-resistant bacteria, with unique antimicrobial characteristics. The antibacterial mechanisms of NPs include cell membrane damage, changing cell wall penetration, ROS production, among others.
JOURNAL OF DRUG TARGETING
(2021)
Article
Pharmacology & Pharmacy
Farhan Alshammari, Bushra Alshammari, Afrasim Moin, Abdulwahab Alamri, Turki Al Hagbani, Ahmed Alobaida, Abu Baker, Salman Khan, Syed Mohd Danish Rizvi
Summary: Ceftriaxone-loaded gold nanoparticles showed better efficacy and targeting against bacterial strains compared to pure ceftriaxone.
Article
Microbiology
Joakim Bjerketorp, Jolanta J. Levenfors, Christina Nord, Bengt Guss, Bo Oberg, Anders Broberg
Summary: Twenty-eight multidrug-resistant bacterial strains closely related or identical to Pedobacter cryoconitis, Pedobacter lusitanus, and Pedobacter steynii were isolated from soil samples by selection for multidrug-resistance. These strains produced a wide array of novel compounds, with Pedobacter strain UP508 producing isopedopeptins and other strains producing different peptides.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hee-Won Han, Kapil D. Patel, Jin-Hwan Kwak, Soo-Kyung Jun, Tae-Su Jang, Sung-Hoon Lee, Jonathan Campbell Knowles, Hae-Won Kim, Hae-Hyoung Lee, Jung-Hwan Lee
Summary: The study identified the antibacterial activity of selenium nanoparticles (SeNPs) against multidrug-resistant bacteria, particularly when combined with the conventional antibiotic linezolid. SeNPs demonstrated synergistic effects with linezolid through protein degradation against MRSA and MSSA. These results suggest the potential of SeNPs as antibacterial substitutes and supplements against MDR bacteria.
Article
Microbiology
Yuvaneswary Veloo, Syahidiah S. A. Thahir, Sakshaleni Rajendiran, Lim K. Hock, Norazah Ahmad, Vickneshwaran Muthu, Rafiza Shaharudin
Summary: The indiscriminate use of antibiotics in poultry farming has led to the emergence of antibiotic-resistant bacteria in poultry products and the surrounding environment. This study found high rates of multidrug-resistant Gram-negative bacteria in the environment of poultry farms, with some strains exhibiting resistance to multiple antibiotics. The presence of these bacteria poses a significant threat to the effectiveness of available antibiotics in treating infectious diseases. Efforts to regulate antibiotic use and conduct research on One Health issues are necessary to combat and prevent the spread of antibiotic-resistant bacteria.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
Yessica Enciso-Martinez, Edwin Barrios-Villa, Cesar O. Sepulveda-Moreno, Manuel G. Ballesteros-Monrreal, Dora E. Valencia-Rivera, Gustavo A. Gonzalez-Aguilar, Miguel A. Martinez-Tellez, Jesus Fernando Ayala-Zavala
Summary: This research investigated the antibiotic resistance of Escherichia coli isolated from the Honeydew melon production system in Hermosillo, Sonora, Mexico. The results showed a high prevalence of antibiotic-resistant, ESBL, and non-ESBL genes in E. coli strains isolated from irrigation water, packing workers' hands, and discarded melons in a farm and packing facility of Honeydew melon in Hermosillo, Sonora.
Article
Chemistry, Multidisciplinary
Le Wang, Wenfu Zheng, Sixiang Li, Leni Zhong, Xingyu Jiang
Summary: This study presents the modification of gold nanoparticles with aminophenol, which demonstrates a broad spectrum of antibacterial effects and strong efficacy against multidrug-resistant bacteria. The mechanisms of action include damaging bacterial cell walls and inhibiting bacterial protein synthesis. In vivo experiments also show promising results in treating abdominal bacterial infections.
Review
Biochemistry & Molecular Biology
Daniel Jesuwenu Ajose, Tesleem Olatunde Abolarinwa, Bukola Opeyemi Oluwarinde, Peter Kotsoana Montso, Omolola Esther Fayemi, Adeyemi Oladapo Aremu, Collins Njie Ateba
Summary: This article examines the potential of plant-derived nanoparticles (PDNPs) as bio-control agents for treating microbial dysfunctions in food-producing animals. By emphasizing a One Health approach, it aims to provide consumers with microbiologically safe food while ensuring food safety and security, improving the health of animals and humans, and creating a safe environment.
Article
Physics, Applied
Nisha Prakash, Manjri Singh, Gaurav Kumar, Arun Barvat, Kritika Anand, Prabir Pal, Surinder P. Singh, Suraj P. Khanna
APPLIED PHYSICS LETTERS
(2016)
Article
Chemistry, Analytical
Meenakshi Choudhary, Prashant Yadav, Anu Singh, Satbir Kaur, Jaime Ramirez-Vick, Pranjal Chandra, Kavita Arora, Surinder P. Singh
Article
Nanoscience & Nanotechnology
Kriti Gupta, Sandeep Kumar, Rinkesh Kumar Gupta, Akanksha Sharma, Alok K. Verma, K. Stalin, Bhushan P. Chaudhari, Mukul Das, Surinder P. Singh, Premendra D. Dwivedi
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2016)
Article
Materials Science, Multidisciplinary
P. L. Meena, K. Sreenivas, M. R. Singh, Ashok Kumar, S. P. Singh, Ravi Kumar
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2016)
Article
Chemistry, Multidisciplinary
Shilpi Verma, Amit Choudhary, Priti Singh, Ashok M. Biradar, Surinder P. Singh
Article
Materials Science, Multidisciplinary
Shilpi Verma, Apoorva Verma, Avanish K. Srivastava, Anurag Gupta, Surinder P. Singh, Priti Singh
MATERIALS CHEMISTRY AND PHYSICS
(2016)
Review
Chemistry, Multidisciplinary
Alok Pandya, Amitkumar N. Lad, Surinder Pal Singh, Rishi Shanker
Article
Environmental Sciences
Himani Uppal, S. Swarupa Tripathy, Sneha Chatula, Bharti Sharma, M. K. Dalai, S. P. Singh, Sulehuir Singh, Nahar Singh
JOURNAL OF ENVIRONMENTAL SCIENCES
(2017)
Article
Biotechnology & Applied Microbiology
Smitha Mony Sreedharan, Sonali Gupta, Anil Kumar Saxena, Rajni Singh
ANNALS OF MICROBIOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Smitha Mony Sreedharan, Surinder Pal Singh, Rajni Singh
INDIAN JOURNAL OF MICROBIOLOGY
(2019)
Article
Nanoscience & Nanotechnology
Smitha Mony Sreedharan, Rajni Singh
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2019)
Article
Biotechnology & Applied Microbiology
Ashim Mitra, Smitha Mony Sreedharan, Rajni Singh
Summary: Concrete structures are prone to cracking, but microbiologically induced calcium carbonate precipitation may be an effective method for repairing cracks. Depositing calcium pellets and bacteria in concrete cracks can provide strength and adhesion, effectively filling the cracks.
INDIAN JOURNAL OF MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Reeta Bhati, Smitha Mony Sreedharan, Asfa Rizvi, Mohammad Saghir Khan, Rajni Singh
Summary: The indiscriminate discharge of heavy metals/metalloids into sustainable agro-ecosystems poses a major threat to food security and human health globally. This study identified and evaluated the arsenic removal/detoxification potential of arsenic-resistant bacteria. Enterobacter cloacae, isolated from an arsenic-rich environment, demonstrated high tolerance to arsenic and possessed the gene (arsC) responsible for the transformation of arsenate to arsenite. In addition, this bacterial strain displayed resistance to other heavy metals and antibiotics. The findings suggest that E. cloacae has the potential for the remediation of arsenic-contaminated environments.
INDIAN JOURNAL OF MICROBIOLOGY
(2022)
Article
Microbiology
Smitha Mony Sreedharan, Niharika Rishi, Rajni Singh
Summary: Microorganisms produce lipopeptides that are active surface agents with amphiphilic properties. These compounds, isolated mainly from Bacillus and Pseudomonas species, exhibit antimicrobial activity against plant pathogens by inhibiting their growth. Lipopeptides have various mechanisms, making them suitable as biocontrol agents. The biosynthesis of lipopeptides involves non-ribosomal peptide synthases, which can be engineered for overproduction and generating new lipopeptides with high efficacy. This review provides an update on the applications of lipopeptides in various fields.
MICROBIOLOGICAL RESEARCH
(2023)
Proceedings Paper
Materials Science, Multidisciplinary
Anu Singh, Meenakshi Choudhary, Satbir Kaur, Surinder P. Singh, Kavita Arora
MATERIALS TODAY-PROCEEDINGS
(2016)