期刊
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷 14, 期 7, 页码 4837-4842出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2014.8275
关键词
Self-Assembly; Photo-Cleavable Linker; Drug Release; Hydrogel
类别
资金
- NSFC [51173060]
A photocleavable nitrobenzyl ester group was introduced in the backbone of self-assembling peptides using standard Fmoc-peptide systhesis. The nitrobenzyl ester group could be used as a cleavable linker to connect a gelator and a hydrophilic group. Photo-irradiation would lead to the generation of the molecular gelator and the formation of a molecular hydrogel. The nitrobenzyl ester group could also be used as one part of hydrophobic capping group for short peptides to produce molecular hydrogelators. In this case, photo-irradiation would lead to the release of hydrophobic anti-imflammatory drug of Naproxen and the gel-sol phase transition. The application of photocleavable group in molecular self-assembly would lead to photo-controllable self-assembly materials for controlled drug release, tissue engineering, and regenerative medicine.
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