Implications of Augmented Renal Clearance on Drug Dosing in Critically Ill Patients: A Focus on Antibiotics

Augmented renal clearance, low β-lactam concentrations and clinical outcomes in the critically ill: An observational prospective cohort study

(2015) Angela Huttner et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Plasma and target-site subcutaneous tissue population pharmacokinetics and dosing simulations of cefazolin in post-trauma critically ill patients

(2015) Jason A. Roberts et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Augmented Renal Clearance in Patients with Subarachnoid Hemorrhage

(2015) Casey C. May et al.   Neurocritical Care

DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current  -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

(2014) J. A. Roberts et al.   CLINICAL INFECTIOUS DISEASES

Risk factors for target non-attainment during empirical treatment with β-lactam antibiotics in critically ill patients

(2014) Jan J. De Waele et al.   INTENSIVE CARE MEDICINE

Identification of optimal renal dosage adjustments for high-dose extended-infusion cefepime dosing regimens in hospitalized patients

(2014) E. Zasowski et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Modified Augmented Renal Clearance score predicts rapid piperacillin and tazobactam clearance in critically ill surgery and trauma patients

(2014) Kevin S. Akers et al.   Journal of Trauma and Acute Care Surgery

Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions

(2014) Jason A Roberts et al.   LANCET INFECTIOUS DISEASES

Monte Carlo simulation analysis of ceftobiprole, dalbavancin, daptomycin, tigecycline, linezolid and vancomycin pharmacodynamics against intensive care unit-isolated methicillin-resistantStaphylococcus aureus

(2013) Ahmed Hamed Salem et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Considerations for Higher Doses of Daptomycin in Critically Ill Patients With Methicillin-Resistant Staphylococcus aureus Bacteremia

(2013) Marco Falcone et al.   CLINICAL INFECTIOUS DISEASES

Augmented Renal Clearance in the ICU

(2013) Andrew A. Udy et al.   CRITICAL CARE MEDICINE

Clinical implications of antibiotic pharmacokinetic principles in the critically ill

(2013) Andrew A. Udy et al.   INTENSIVE CARE MEDICINE

Augmented renal clearance is a common finding with worse clinical outcome in critically ill patients receiving antimicrobial therapy

(2013) Barbara O.M. Claus et al.   JOURNAL OF CRITICAL CARE

Variability of pharmacokinetic parameters in patients receiving different dosages of daptomycin: is therapeutic drug monitoring necessary?

(2013) Marco Falcone et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Augmented Renal Clearance of Vancomycin and Levetiracetam in a Traumatic Brain Injury Patient

(2013) Aaron M. Cook et al.   Neurocritical Care

Augmented Renal Clearance in the Critically Ill: How to Assess Kidney Function

(2012) Veerle Grootaert et al.   ANNALS OF PHARMACOTHERAPY

Continuous Infusion of Beta-Lactam Antibiotics in Severe Sepsis: A Multicenter Double-Blind, Randomized Controlled Trial

(2012) J. M. Dulhunty et al.   CLINICAL INFECTIOUS DISEASES

What's behind the failure of emerging antibiotics in the critically ill? Understanding the impact of altered pharmacokinetics and augmented renal clearance

(2012) Andrew A. Udy et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Augmented renal clearance in septic patients and implications for vancomycin optimisation

(2012) João Pedro Baptista et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

High creatinine clearance in critically ill patients with community-acquired acute infectious meningitis

(2012) Alexandre Lautrette et al.   BMC Nephrology

Subtherapeutic Initial β-Lactam Concentrations in Select Critically Ill Patients

(2011) Andrew A. Udy et al.   CHEST

The role of pharmacokinetics/pharmacodynamics in setting clinical MIC breakpoints: the EUCAST approach

(2011) J.W. Mouton et al.   CLINICAL MICROBIOLOGY AND INFECTION

ARC - Augmented Renal Clearance

(2011) Andrew A. Udy et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Physiological Changes in the Critically Ill Patient with Sepsis

(2011) Shaun Hosein et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Pitfalls of using estimations of glomerular filtration rate in an intensive care population

(2011) J. H. Martin et al.   INTERNAL MEDICINE JOURNAL

Optimizing ciprofloxacin dosing in intensive care unit patients through the use of population pharmacokinetic-pharmacodynamic analysis and Monte Carlo simulations

(2011) D. Khachman et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Steady-State Pharmacokinetics of Intravenous Levetiracetam in Neurocritical Care Patients

(2011) Dustin D Spencer et al.   PHARMACOTHERAPY

Augmented Creatinine Clearance in Traumatic Brain Injury

(2010) Andrew Udy et al.   ANESTHESIA AND ANALGESIA

Pharmacokinetic‐Pharmacodynamic Considerations in the Design of Hospital‐Acquired or Ventilator‐Associated Bacterial Pneumonia Studies: Look before You Leap!

(2010) Paul G. Ambrose et al.   CLINICAL INFECTIOUS DISEASES

Augmented Renal Clearance

(2009) Andrew A. Udy et al.   CLINICAL PHARMACOKINETICS

Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution

(2009) Jason A. Roberts et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Therapeutic monitoring of vancomycin in adult patients: A consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists

(2008) M. Rybak et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Influence of glomerular filtration rate on the clearance of vancomycin administered by continuous infusion in burn patients

(2008) Eric Dailly et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS