Review
Chemistry, Physical
Zahra Ebrahimvand Dibazar, Lei Nie, Mehdi Azizi, Houra Nekounam, Masoud Hamidi, Amin Shavandi, Zhila Izadi, Cedric Delattre
Summary: Bone tissue engineering combines biomaterials, cells, and bioactive agents to provide advanced treatment options. Scaffolds play a central role, and precise design and fabrication of structures that closely resemble bone tissue have shown promising results. The use of nanotechnology and nanomaterials in scaffolds allows for tailored physicochemical properties and improved interactions with cells and surrounding tissues. Polymeric and carbon nanofibers have attracted attention due to their similarity to bone extracellular matrix and high surface-to-volume ratio. Mineralized nanofibers have shown potential in enhancing bone healing in tissue engineering applications.
Article
Chemistry, Applied
Syrine Dimassi, Nicolas Tabary, Feng Chai, Cedric Zobrist, Jean-Christophe Hornez, Frederic Cazaux, Nicolas Blanchemain, Bernard Martel
Summary: This study investigates the influence of treatment time of electrospun chitosan nanofibers in dopamine bath on polydopamine coating and biomimetic deposition of hydroxyapatite. The scaffolds showed promising cytocompatibility and induced biomineralization in vitro, making them potential candidates for bone regeneration applications. Characterization by FTIR, SEM, XRD, and SEM-EDS confirmed the formation of apatitic phase particles on the surface of the scaffolds.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Kristina Peranidze, Tatiana V. Safronova, Nataliya R. Kildeeva
Summary: Currently, the field of tissue engineering is focused on developing polymer-based materials with suitable microenvironments for cell attachment, differentiation, and proliferation. The biomimicking approach aims to create biocompatible and bioactive materials that mimic the structural features of the natural extracellular matrix. This study discusses promising fibrous materials for bone tissue regeneration obtained through electrospinning techniques, including natural and synthetic polymers combined with bioactive inorganic materials.
Article
Biochemistry & Molecular Biology
Frederico Barbosa, Frederico Castelo Ferreira, Joao Carlos Silva
Summary: Osteochondral tissue engineering is a promising strategy for treating diseases such as osteoarthritis. However, current research focuses mainly on the structural and mechanical properties of the tissue, while neglecting its piezoelectric properties. This review summarizes the recent advances in the application of piezoelectric electrospun scaffolds for replacing damaged osteochondral tissue and promoting its regeneration, and discusses the current challenges and future perspectives.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Muheeb Rafiq, Sami-ullah Rather, Taha Umair Wani, Anjum Hamid Rather, Rumysa Saleem Khan, Anees Ellahi Khan, Ibtisam Hamid, Haseeb A. Khan, Abdullah S. Alhomida, Faheem A. Sheikh
Summary: After the discovery of MXene, a new class of 2D material, researchers have found a new scope for their research. MXenes have remarkable physical, chemical, and biological properties, making them useful in various research disciplines. They have been applied in biosensors, bioimaging, tissue engineering, drug delivery systems, and more. MXenes can be functionalized with different atoms/molecules, making them diverse materials. Their potential in nanofibers is even greater than expected.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Jingzhe Zhang, Xinkun Wang, Xinbiao Fu, Ye Li, Rubo Li
Summary: In this study, electroconductive aligned carbon nanofibers (CNFs) were fabricated as a scaffold for nanofibers-guided bone regeneration. The results showed that the aligned nanofibers had high conductivity and biocompatibility, and influenced the direction of cell growth.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Applied
Bikendra Maharjan, Jeesoo Park, Vignesh Krishnamoorthi Kaliannagounder, Ganesh Prasad Awasthi, Mahesh Kumar Joshi, Chan Hee Park, Cheol Sang Kim
Summary: This study addressed the insufficient mechanical strength of natural hydrogel scaffolds in bone tissue engineering by incorporating regenerated cellulose nanofibers into chitosan hydrogel. The resulting rCL/CS composite scaffold showed improved compressive strength, biomineralization, and pre-osteoblast cell viability. The enhanced osteogenic differentiation ability of rCL/CS composite scaffold suggests its promise as a three-dimensional bio-scaffold for bone tissue engineering.
CARBOHYDRATE POLYMERS
(2021)
Review
Biochemistry & Molecular Biology
Sakshi Priya, Unnati Batra, B. N. Samshritha, Sudhanshu Sharma, Akash Chaurasiya, Gautam Singhvi
Summary: Nanofibers are fibrous nanocarriers that can be synthesized from various materials, including natural polymers. Natural polysaccharides-based nanofibers have gained attention in pharmaceutical and biomedical applications due to their biocompatibility, biodegradability, non-toxicity, and economic advantages. However, there is a lack of research on the scale-up and advanced therapeutic delivery of nanofibers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Abolfazl Mozaffari, Mazeyar Parvinzadeh Gashti
Summary: In this study, tannic acid-crosslinked gelatin nanofibers were fabricated by electrospinning and treated with atmospheric air plasma to enhance their bio-functionality. The results showed that atmospheric air plasma treatment not only improved the hydrophilicity of the nanofibers but also enhanced their bio-functionality against human skin fibroblast cells. Therefore, atmospheric air plasma pre-treatment is recommended for the surface functionalization of gelatin nanofibers in skin tissue engineering applications.
Article
Pharmacology & Pharmacy
Hossein Derakhshankhah, Houra Nekounam, Zhil Izadi, Zahra Allahyari, Mahya Samari, Meysam Feizi, Hadi Samadian
Summary: This study fabricates a promising scaffold for bone tissue engineering based on carbon nanofibers (CNFs) composited with magnesium oxide nanoparticles (MgO-NPs). The incorporation of MgO-NPs improves the surface properties of CNFs and reduces the fiber diameter, with the nanoparticles uniformly distributed in the nanofibers. In vitro tests demonstrate that the nanofibers with 15% NPs exhibit the lowest amount of hemolysis and the highest hemocompatibility. The combination of CNFs' nanofibrous structure and MgO-NPs' particulate morphology results in a nano-composite with beneficial properties for bone tissue engineering.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Norul Ashikin Norzain, Zhi-Wei Yu, Wei-Chih Lin, Hsing-Hao Su
Summary: This study describes the fabrication of a structural scaffold with a combination of randomly oriented nanofibers and triangular prism patterns, showing improved fibroblast cell proliferation and orientation compared to flat random nanofibers. The scaffold accelerated wound closure in vivo and exhibited advanced healing properties.
Review
Chemistry, Multidisciplinary
Jie Cui, Xiao Yu, Yihong Shen, Binbin Sun, Wanxin Guo, Mingyue Liu, Yujie Chen, Li Wang, Xingping Zhou, Muhammad Shafiq, Xiumei Mo
Summary: Tissue engineering has gained widespread attention as a method of producing patient-specific tissue constructs for tissue repair. Different types of scaffold materials have been developed, and the choice of materials should consider their mechanical properties, biodegradability, biocompatibility, and bioresorbability. Inorganic materials, with their broad range of physico-chemical properties, can be used as scaffold fillers and offer a good alternative for tissue engineering. This review focuses on the use of inorganic components in electrospun membranes and emphasizes the biological advantages of incorporating inorganic materials in tissue repair.
Article
Chemistry, Multidisciplinary
Marcus Himmler, Dirk W. Schubert, Thomas A. Fuchsluger
Summary: The study analyzed the light transmission through electrospun PCL scaffolds and its impact on the transparency of nanofibrous scaffolds. Results showed that scaffold thickness, fiber diameter, and surrounding medium play crucial roles in light transmission. Smaller fiber diameter and matching refractive indices help improve light transmission.
Article
Biochemistry & Molecular Biology
Yasamin Alikhasi Amnieh, Sepideh Ghadirian, Nayereh Mohammadi, Mohammad Shadkhast, Saeed Karbasi
Summary: In this study, chitosan nanoparticles (Cs) were synthesized and incorporated into polyhydroxy butyrate (PHB) electrospun scaffolds for cartilage tissue engineering. The mechanical properties, hydrophilicity, and fiber diameter of the PHB scaffolds with varying concentrations of Cs nanoparticles were evaluated. The scaffold containing 1 wt% Cs nanoparticles (P-1Cs) showed optimal properties with increased strength and elongation at break compared to pure PHB. Crystallinity, degradation, and cell compatibility were also evaluated, and Cs nanoparticles were found to improve cell proliferation on the scaffold.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Multidisciplinary
Andrea Luraghi, Francesco Peri, Lorenzo Moroni
Summary: Drug delivery devices are promising in maximizing therapeutic effects and minimizing undesired side effects. Electrospun nanofibers have unique features like biocompatibility and flexibility, making them efficient in delivering active principles for a wide range of drugs. The technique of electrospinning allows for easy tuning and endless combinations, potentially leading to personalized medicine.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Green & Sustainable Science & Technology
Piya Kerdlap, Aloisius Rabata Purnama, Jonathan Sze Choong Low, Daren Zong Loong Tan, Claire Y. Barlow, Seeram Ramakrishna
Summary: The study compares the environmental performance of distributed and centralized sorting and recycling of plastic bottles and takeaway containers in Singapore, finding that distributed scenarios have higher environmental impacts in terms of climate change, water depletion, and terrestrial ecotoxicity by 7-30% compared to centralized scenarios.
JOURNAL OF INDUSTRIAL ECOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Wanasinghe Arachchige Dumith Madushanka Jayathilaka, Amutha Chinnappan, Rituparna Ghosh, Chinnappan Baskar, Seeram Ramakrishna
Summary: Passive radiative cooling using metal oxide-doped fibers is an effective energy-saving method that achieves cooling without external energy input. These fibers have high reflectivity and emissivity within the atmospheric window, resulting in significant cooling effects below ambient temperatures.
ADVANCED ENGINEERING MATERIALS
(2022)
Article
Polymer Science
Banafsheh Sadeghi, Peyman Sadeghi, Yousef Marfavi, Elaheh Kowsari, Ali Akbar Zareiyazd, Seeram Ramakrishna
Summary: This study introduces two solutions to improve the foaming of PLA: using the extrusion process and adding cellulose nanofibers. Experimental results showed a reduction in the molecular weight of original PLA after extrusion, and an enhancement in crystallization nucleation and cell density with the addition of cellulose nanofibers. The composition of cellulose nanofibers also improved the mechanical and dynamic properties of cellulose nanofiber-reinforced PLA based on the dynamic-mechanical thermal analysis.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Review
Engineering, Environmental
Manik Chandra Biswas, Bodiuzzaman Jony, Pranab Kumar Nandy, Reaz Ahmed Chowdhury, Sudipta Halder, Deepak Kumar, Seeram Ramakrishna, Masud Hassan, Md Ariful Ahsan, Md Enamul Hoque, Muhammad Ali Imam
Summary: Biopolymers have unique tunable characteristics such as biodegradability, biocompatibility, renewability, which are critically important for designing materials for biomedical applications. By changing the polymer components, smart biopolymers can be prepared for more targeted applications, showing a wide range of uses in drug delivery and wound healing, among others.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Polymer Science
Alireza Behzadi, Ghodratollah Hashemi Motlagh, Erfan Rezvani Ghomi, Rasoul Esmaeely Neisiany, Iman Jafari, Amutha Chinnappan, Fatemeh Khosravi, Seeram Ramakrishna
Summary: Organic resorcinol formaldehyde (RF) aerogel was successfully modified by incorporating amine-functionalized graphene oxide (GO) during the synthesis process. The modified RF-GOA showed improved elimination amounts of antibiotics and a high absorption capacity for oxytetracycline and chlortetracycline. The optimal pH values for the modified aerogels were obtained, and the adsorption of antibiotics on the modified aerogels was found to be governed by chemical adsorption.
Review
Engineering, Biomedical
Impreet Kaur, Rajnish Tiwari, V. G. M. Naidu, Seeram Ramakrishna, Dinesh M. Tripathi, Savneet Kaur
Summary: This review highlights the role of bile acids and their signaling pathways in liver regeneration, as well as the potential of bile acid-based therapies in liver diseases. The expression of major bile acid receptors in both the liver and intestine contributes significantly to hepatocyte proliferation, and selective agonists of these pathways are being developed as new therapies for liver diseases. FXR/TGR5 agonists show promise in promoting liver regeneration and improving hepatic insufficiency in chronic liver diseases.
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2022)
Article
Engineering, Biomedical
Abd Rahim Aiman, Sevakumaran Vigneswari, Nur Athirah Amran, Vikneswaran Murugaiyah, Al-Ashraf Amirul, Seeram Ramakrishna
Summary: Regenerative medicine utilizes cellular and tissue regeneration principles to develop strategies that provide cures rather than treatment for complex diseases, through methods such as stem cells, gene therapy, and tissue engineering. Biomaterials play a crucial role in tissue engineering, and the development of smart biomaterials is the way forward for regenerative medicine applications in the future.
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Raj Kumar, Keshaw Ram Aadil, Kunal Mondal, Yogendra Kumar Mishra, David Oupicky, Seeram Ramakrishna, Ajeet Kaushik
Summary: Neurodegenerative disorders are prevalent among the aging population, causing memory loss and motor coordination issues, leading to significant socio-economic burdens. Nano-biotechnology-based approaches offer effective and personalized alternatives for managing these diseases.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Pavni Rekhi, Moushmi Goswami, Seeram Ramakrishna, Mousumi Debnath
Summary: Polymers are essential in modern living, but those with a large carbon footprint are increasingly seen as harmful to the environment. Polyhydroxyalkanoate (PHA) is regarded as a potential alternative derived from microbial biopolymer. PHA shows promise for various applications, particularly in the medical sector due to its biodegradability and biocompatibility.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Hossein Sharifi, Behrooz Mosallanejad, Mohammadkhalil Mohammadzad, Seyed Morteza Hosseini-Hosseinabad, Seeram Ramakrishna
Summary: The study found that cycling-induced aging at different C-rates significantly impacts the performance of LiFePO4/graphite full cells, especially at relatively high current rates where the formation of an active lithium ion-impermeable covering layer on the anode surface leads to electrode performance degradation. This degradation is mainly attributed to the instability of the electrode/electrolyte interface and the solid electrolyte interphase (SEI) layer, causing the loss of active lithium ions and ultimately resulting in electrode deactivation.
Article
Engineering, Electrical & Electronic
Afsaneh Valipouri, Hajar Hosseinian, Seyed Abdolkarim, Hosseini Ravandi, Afifeh Karimian
Summary: This research proposes a new method for producing polymer microparticles, and evaluates the critical conditions of microparticles using an electro-centrifuge spinning system. The results show that the number of particles increases with solution concentration and the particle size decreases with voltage. At high rotating speeds, the particles stick together before drying, creating a smooth surface.
JOURNAL OF ELECTROSTATICS
(2022)
Article
Materials Science, Composites
Afifeh Karimian, Afsaneh Valipouri, Iman Amouhadi, Mohsen Badrossamay, Mohammad Ali Alsharif
Summary: 3D printing can be used to deposit polymers onto textiles for wearable thermoelectric devices. The adhesion strength of the printed polymer layers on polypropylene fabric was evaluated through a peeling test. The optimal printing parameters were determined to achieve higher peeling force, and the morphology of the printed layer was analyzed using FE-SEM.
POLYMER COMPOSITES
(2023)
Article
Materials Science, Composites
Abdulkarim Alsikh, Afsaneh Valipouri, Mohsen Nasr Esfahany, Seyed Abdolkarim Hosseini Ravandi
Summary: This article investigates the dynamic performance of an advanced multifunctional textile under solar radiation. The influence of fabric properties and optical properties on evaporation performance is discussed. The results show that the proposed multi-layer structure has excellent potential in solar absorption efficiency and evaporation performance.
POLYMER COMPOSITES
(2023)
Review
Chemistry, Analytical
Xue Pan, Lu Bai, Chengcheng Pan, Zhicheng Liu, Seeram Ramakrishna
Summary: This review discusses the fabrication methods and applications of SERS substrates based on electrospun nanofibers, and highlights the challenges and prospects.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Review
Engineering, Biomedical
Masoud Sarraf, Erfan Rezvani Ghomi, Saeid Alipour, Seeram Ramakrishna, Nazatul Liana Sukiman
Summary: Commercially pure titanium and titanium alloys are widely used in biomedical applications due to their excellent mechanical properties, corrosion resistance, biocompatibility, and antibacterial properties. Future research will focus on advanced manufacturing technologies, effects of alloying elements on biocompatibility, and the role of titanium in regenerative and nanomedicine applications.
BIO-DESIGN AND MANUFACTURING
(2022)
