期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 138, 期 -, 页码 96-103出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2015.09.013
关键词
Biochanin A; Microglia; Dopaminergic neuron; Oxidative stress; NADPH oxidase; Parkinson's disease
资金
- National Natural Science Foundation of China (NSFC) fund [31171650]
- Natural Science Foundation of Anhui Province Education Department [KJ2014A115]
- Anhui Provincial Natural Science Foundation [1508085MH186]
- Open Project Program of State Key Laboratory of Food Science and Technology, Jiangnan University, China
Parkinson's disease (PD) is the second most common neurodegenerative disease, which is characterized by loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Accumulated evidences have suggested that oxidative stress is closely associated with the dopaminergic neurodegeneration of PD that can be protected by antioxidants. Biochanin A that is an O-methylated isoflavone in chickpea is investigated to explore its protective mechanism on dopaminergic neurons of the unilateral lipopolysaccharide (LPS)-injected rat. The results showed that biochanin A significantly improved the animal model's behavioral symptoms, prevented the loss of dopaminergic neurons and inhibited the deleterious microglia activation in the LPS-induced rats. Moreover, biochanin A inhibited nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) activation and malondialdehyde (MDA) production, increased superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities in the rat brain. These results suggested that biochanin A might be a natural candidate with protective properties on dopaminergic neurons against the PD. (C) 2015 Elsevier Inc All rights reserved.
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