Article
Nutrition & Dietetics
Keri Lanier, Breanna Wisseman, Cody Strom, Carol A. Johnston, Christy Isler, James DeVente, Edward Newton, Roman Pawlak, Brittany R. Allman-Tucker, Samantha McDonald, Linda E. May
Summary: In the United States, pregnant women have low concentrations of DHA and EPA, which are essential for fetal development. The consumption of PUFA-containing foods can reflect the status of DHA and EPA in maternal blood. This study aimed to determine the association between maternal self-reported dietary intake of foods high in DHA and EPA and maternal blood concentrations of DHA and EPA.
Article
Biotechnology & Applied Microbiology
Hyeyoun Chang, Ji Young Yhee, Sangmin Jeon, Man Kyu Shim, Hong Yeol Yoon, Sangmin Lee, Kwangmeyung Kim
Summary: Repeated high-dose administration of CNPs in healthy mice induces severe cardiotoxicity, including inflammatory responses, tissue damages, fibrotic changes, and organ dysfunction.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Samaneh Bagheri Novir, Arash Tirandaz, Hoda Lotfipour
Summary: The quantum properties of DHA/DPA/EPA molecules have been studied theoretically and computationally. The quantum chemical calculations revealed how these omega-3 polyunsaturated fatty acids can impact their biological functions, with DHA identified as a superior host for quantum agents.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Food Science & Technology
Alejandra Valencia-Naranjo, Luz M. Manjarres-Correa, Juliana Bermudez-Cardona
Summary: This study aimed to evaluate the changes in the concentrations of EPA and DHA in the erythrocytes and breast milk of lactating women after three months of supplementation. The study found low consumption of omega-3 food sources and low EPA and DHA content initially. After supplementation, there was a significant increase in DHA levels in both erythrocytes and breast milk, while EPA levels did not change significantly.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Hoon Hyun, Min Ho Park, Gayoung Jo, Bo Young Lee, Jae Won Choi, Heung Jae Chun, Hyeon Soo Kim, Dae Hyeok Yang
Summary: The study developed a novel drug carrier for breast cancer therapy, with MGC/CDPF-ic-PTX showing promising anti-cancer effects, enhanced cellular uptake, sustained release, and potential therapeutic efficacy against breast cancer.
Article
Biochemistry & Molecular Biology
Bjorg Kristine Hundal, Esmail Lutfi, Trygve Sigholt, Grethe Rosenlund, Nina Sylvia Liland, Brett Glencross, Nini Hedberg Sissener
Summary: This study aimed to investigate the effects of different levels of EPA and DHA on the hepatic metabolic health of Atlantic salmon reared in sea cages. The results showed that feeding low levels of EPA+DHA altered hepatic energy metabolism, resulting in reduced beta-oxidation and compensated by increased activity in alternative energy pathways. Increased acylcarnitines in the liver indicated issues with lipid metabolism. Fish fed higher levels of EPA+DHA showed improved growth compared to other groups.
Article
Biochemistry & Molecular Biology
Siyan Yu, Qunying Xie, Weifeng Tan, Manjiang Hu, Guiling Xu, Xiao Zhang, Guanghang Xie, Limei Mao
Summary: This study found that supplementation of fish oil with an appropriate higher ratio of DHA (1.5:1) can alleviate insulin resistance, reduce adipocyte hypertrophy and oxidative stress, improve lipid metabolism, and reduce hepatic steatosis in high-fat diet-induced insulin resistance mice.
Article
Chemistry, Applied
Xuexi Wang, Min Jin, Xin Cheng, Xiaoying Hu, Mingming Zhao, Ye Yuan, Peng Sun, Lefei Jiao, Douglas R. Tocher, Monica B. Betancor, Qicun Zhou
Summary: The study showed that dietary DHA/EPA ratio can impact the lipid molecular species and fatty acid positional distribution in mud crab hepatopancreas. An optimal ratio can increase specific lipid contents and affect esterified site distribution.
Article
Chemistry, Multidisciplinary
Bo-Han Huang, Li-Jie Chen, Yu-Jie Chiou, Grace Whang, Yunkai Luo, Yichen Yan, Kung-Hwa Wei, Ximin He, Bruce Dunn, Pu-Wei Wu
Summary: A chitosan composite with vertical channels was fabricated using electrophoretic deposition, showing impressive water uptake and slow release of silver. This composite demonstrated excellent structural integrity and adhesive force towards objects with different surface curvatures.
Article
Medicine, General & Internal
Marina Ivanisevic, Marina Horvaticek, Karlo Delmis, Josip Delmis
Summary: This study found that supplementation with DHA and EPA in pregnant women with type 1 diabetes can increase the concentration and proportions of n-3 PUFAs in maternal and fetal blood, while decreasing the proportion of n-6 PUFAs.
ANNALS OF MEDICINE
(2021)
Article
Cell Biology
Jing Chen, Esther A. Zaal, Celia R. Berkers, Rob Ruijtenbeek, Johan Garssen, Frank A. Redegeld
Summary: The study demonstrates that pretreating MM cells with DHA/EPA before bortezomib significantly enhances chemosensitivity by decreasing GSH levels and altering metabolism, highlighting the role of GSH degradation in overcoming drug resistance. RNA-seq results suggest the NRF2-ATF3/4-CHAC1 signaling pathway as central in GSH degradation and indicate potential connections to various pathways contributing to the tumor suppressive effect. The findings implicate GSH degradation as a promising therapeutic target in MM and provide new insights into combating bortezomib resistance.
Article
Multidisciplinary Sciences
Dhavamani Sugasini, Jason C. Park, J. Jason McAnany, Tae-Hoon Kim, Guangying Ma, Xincheng Yao, Babu Antharavally, Anil Oroskar, Asha A. Oroskar, Brian T. Layden, Papasani V. Subbaiah
Summary: Alzheimer's disease (AD) is a common cause of dementia in the elderly, and visual abnormalities often precede cognitive symptoms. This study aimed to investigate whether enriching retinal docosahexaenoic acid (DHA) through dietary lysophosphatidylcholine (LPC) could improve retinopathy in a mouse model of AD. The results showed that 5XFAD mice had lower retinal DHA levels compared to wild type mice, and feeding LPC-DHA and eicosapentaenoic acid (EPA) increased DHA and EPA levels in the retina. Electroretinography measurements showed that the LPC-DHA/EPA diet improved retinal function, while the triacylglycerol (TAG)-DHA/EPA diet had only modest effects. These findings suggest that enriching retinal DHA and EPA through dietary LPC may improve visual abnormalities associated with AD.
SCIENTIFIC REPORTS
(2023)
Article
Agricultural Engineering
Zhongxiang Fu, Tiantian Zhao, Baijun Chu, Weizheng Gao, Tong Li, Zhao Zhang, Qingyang Li, Dongzhe Sun
Summary: Low and high temperatures have a significant impact on the synthesis of DHA in C. sp. SUN. The findings suggest that DHA synthesis does not occur through the fatty acid synthesis pathway, but possibly through the PUFA synthase pathway. The substrate preference of diacylglycerol acyltransferases for saturated fatty acid-CoA also contributes to the regulation of DHA proportion. WGCNA analysis identifies key regulatory genes involved in temperature-regulated DHA proportion.
BIORESOURCE TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Yiming Li, Weina Tian, Zhongxiang Fu, Wenqi Ye, Xinwei Zhang, Zhao Zhang, Dongzhe Sun
Summary: This study investigated the regulatory mechanisms of intracellular organic carbon distribution in Crypthecodinium sp. SUN using different carbon sources. Results showed that sodium acetate caused a significant increase in total fatty acid (TFA) accumulation and DHA percentage. Transcriptome and metabolome analysis revealed that increased intracellular acetyl-CoA content and the accumulation of DHA-rich metabolites of lipid biosynthesis contributed to the higher TFA content and DHA percentage.
Article
Biochemistry & Molecular Biology
Enchao Liu, Shenghan Zhao, Xiao Li, Xianghong Meng, Bingjie Liu
Summary: In this study, a novel DHA-loaded nanoparticle (PCSDNP) with PLGA and chitosan was successfully prepared. The particle structure and interactions were analyzed through various microscopy techniques and FTIR spectroscopy. PCSDNP showed better stability and controlled release properties under different environmental conditions, mainly attributed to hydrogen bonds and electrostatic interactions between PLGA and chitosan, demonstrating potential for biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)