期刊
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷 10, 期 2, 页码 826-832出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2010.1805
关键词
Gold Nanoparticle; Citrate Synthase; Chaperon; Protein Aggregation; Gold Nanoparticle; Plasmonic Shift; Size Dependence
类别
资金
- CSIR India [37/1275/06]
- DST India [SR/NM/NS-28/2007]
Citrate synthase is a heat labile enzyme showing a loss of activity even in response to a modest shift of temperature (35 degrees-45 degrees C). Gold nanoparticle is shown to prevent the thermal aggregation of this enzyme. The chaperon like activity of the nanoparticle diminishes if the particle size is reduced from 40 nm to 20 nm keeping the atomic concentration of gold constant. This implies that the effect is not merely due to enhanced surface area offered by the nano-surfaces. The effect is reversible as the protein separated out from nanoparticles behaves similar to control. The observed coupling between chaperon activity of the nanoparticle and its cluster forming ability is illustrated in terms of a thermal cage model.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据