Article
Nanoscience & Nanotechnology
Xuanwen Xu, Yi Zhou, Kai Zheng, Xinyu Li, Lu Li, Yan Xu
Summary: Periodontitis is a chronic inflammatory disease that affects people worldwide and has an uncertain prognosis with surgical treatment. In this study, a three-dimensional scaffold made of electrospun polycaprolactone/gelatin fibrous membranes was developed to overcome the challenges of periodontal treatment. The scaffold showed good properties and promoted adhesion and proliferation of human periodontal ligament stem cells. In vivo experiments confirmed that the scaffold could guide cellular orientation and potentially facilitate periodontal regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
M. A. El-Morsy, M. Afifi, M. K. Ahmed, Nasser S. Awwad, Hala A. Ibrahium, Mohammed S. Alqahtani
Summary: In this study, scaffold compositions were manipulated to enhance wound healing by accelerating the curing process and inhibiting bacterial growth. Powder and fibrous phases of Pd/V-HAP were prepared with different Pd(II) ion contents. The structural and morphological characteristics of the compositions were examined using XRD and FESEM techniques. The highest palladium composition showed a clear porous structure in the powder phase and a significant reduction in fiber filament diameter in the fibrous phase. The 0.8Pd/V-HAP@PCL scaffold exhibited the narrowest contact angle and the highest cell viability. Furthermore, the 0.8Pd/V-HAP@PCL nano fibrous composite demonstrated the maximum inhibition zones against E. coli and S. aureus microorganisms. The cellular growth of fibroblasts cell line increased with the change of nanofiber compositions, indicating the potential of these biomaterials for wound care applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Elahe Gholipour Choubar, Mohammad Hossein Nasirtabrizi, Farshid Salimi, Nastaran Sohrabi-gilani, Ali Sadeghianamryan
Summary: Co-electrospinning method was used to synthesize PCL/COL/PVP nanofibrous scaffolds for bone tissue engineering. The scaffolds exhibited uniform morphology and good mechanical and biodegradable properties, making them promising for bone regeneration.
JOURNAL OF MATERIALS RESEARCH
(2022)
Article
Chemistry, Physical
Khrystyna Malysheva, Konrad Kwasniak, Iaroslav Gnilitskyi, Adriana Barylyak, Viktor Zinchenko, Amir Fahmi, Olexandr Korchynskyi, Yaroslav Bobitski
Summary: The study successfully fabricated hydroxyapatite and fluorapatite functionalized composite scaffolds based on electrospun polycaprolactone, which demonstrated good biocompatibility and osteoinductive properties towards mesenchymal stem cells. The incorporation of fluorapatite nanoparticles enhanced the scaffolds' wettability and ability to support attachment of mesenchymal stem cells, showing potential for future bone tissue engineering applications.
Article
Polymer Science
Diana Querido, Tania Vieira, Jose Luis Ferreira, Celia Henriques, Joao Paulo Borges, Jorge Carvalho Silva
Summary: Hybrid scaffolds obtained by combining two or more biopolymers are studied in the context of tissue regeneration. This study produced a new type of hybrid polycaprolactone (PCL)/chitosan (CS) electrospun mat by controlling the deposition of CS flakes between PCL fibers. The morphology of the resulting fibers confirmed the presence of CS flakes. In vitro cell culture results showed that the addition of CS reduced cell adhesion and proliferation.
Article
Polymer Science
Elif Saatcioglu, Songul Ulag, Ali Sahin, Betul Karademir Yilmaz, Nazmi Ekren, Ahmet Talat Inan, Yuksel Palaci, Cem Bulent Ustundag, Oguzhan Gunduz
Summary: In this study, electrospinning was used to fabricate PCL scaffolds with different percentages of Chitosan, with 10wt.%PCL/3wt.%CS showing the highest tensile strength value and good viability for mesenchymal stem cells. The scaffolds exhibited a suitable geometry for ligament-like tissue and allowed for the attachment of MSCs in a network-like structure.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Iman Shirzaei Sani, Mostafa Rezaei, Ali Baradar Khoshfetrat, Donya Razzaghi
Summary: Chitosan and poly (epsilon-caprolactone) were combined to fabricate bone tissue engineering scaffolds with enhanced bioactivity and mechanical properties. The incorporation of chitosan-g-poly (epsilon-caprolactone) significantly decreased fiber diameter and hydroxyapatite nanoparticles enhanced mineralization and degradation of the scaffold. In vitro cytocompatibility assays showed high cell viability and proliferation, indicating the potential use of the microfabricated nanocomposite scaffolds in bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Felipe Castro Menezes, Nataly Machado Siqueira, Stephanie Fung, Joice Maria Scheibel, Dinara Jaqueline Moura, Murat Guvendiren, Joachim Kohn, Rosane Michele Duarte Soares
Summary: Electrospinning is a versatile technique for producing composite scaffolds with nanostructure properties similar to the natural extracellular matrix. In this study, the effects of fiber alignment, mechanical properties, and chemical modifications on the physicochemical properties of composite scaffolds were investigated. The results showed that incorporating gelatin and aligning the fibers improved the wettability and mechanical strength of the material, and promoted osteoinduction.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Chemistry, Physical
Maria I. Echeverria I. Molina, Chi-An Chen, Jeniree Martinez, Perry Tran, Kyriakos Komvopoulos
Summary: Fully functional skin regeneration is still difficult after decades of research. Scaffold engineering, a leading field in skin substitutes, can optimize the biomolecular exchange to promote the formation of high-quality tissue. This study designed and evaluated a new class of three-dimensional fibrous scaffolds that induce keratinocyte differentiation through calcium leaching, demonstrating their potential for tissue engineering.
Article
Engineering, Biomedical
Hugues Mondesert, Frederic Bossard, Denis Favier
Summary: This study investigates anisotropic fibrous scaffolds fabricated by template-assisted electrospinning, showing significant differences in mechanical properties along two orthogonal directions with an anisotropic ratio of 4.2. Through tensile test experiments and stress relaxation test, the study reveals the low contribution of viscosity in the mechanical response of the scaffold. An orthotropic linear elastic model is proposed to characterize the anisotropic behavior of the patterned membranes, offering potential benefits for soft regenerative medicine applications and custom-made scaffolds.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Polymer Science
L. A. Can-Herrera, A. I. Oliva, M. A. A. Dzul-Cervantes, O. F. Pacheco-Salazar, J. M. Cervantes-Uc
Summary: The study investigates the effect of applied voltage on electrospun PCL scaffolds, finding that increasing voltage significantly affects the morphology and mechanical properties of the fibers. This has important implications for tissue engineering applications.
Article
Biotechnology & Applied Microbiology
Xingtai Huang, Qirui Wang, Runyi Mao, Zeying Wang, Steve G. F. Shen, Juan Mou, Jiewen Dai
Summary: In this study, a versatile organic-inorganic composite scaffold was constructed by embedding two-dimensional vermiculite nanosheets in polycaprolactone electrospun fibers. This scaffold can enhance angiogenesis through activation of the HIF-1 alpha signaling pathway and promote diabetic wound healing.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Polymer Science
Mauro Petretta, Alessandro Gambardella, Giovanna Desando, Carola Cavallo, Isabella Bartolotti, Tatiana Shelyakova, Vitaly Goranov, Marco Brucale, Valentin Alek Dediu, Milena Fini, Brunella Grigolo
Summary: The study developed magnetically assisted PCL-HAp-1% SPION scaffolds, showing promising results in terms of cell proliferation and osteogenic potential, indicating the potential for further in vitro and in vivo studies and validations.
Article
Chemistry, Physical
Asma M. Alturki
Summary: Altering the nanofibrous structure is crucial for improving wound healing applications. In this study, co-substituted hydroxyapatite (HAP) with different iron (Fe)/vanadate (VO43-) ions contributions in polycaprolactone (PCL) was fabricated using the electrospinning method. The structural features, surface morphology, mechanical parameters, and cell viability were analyzed. The results show that increasing the dopant ions improves the mechanical properties and cell growth of the nanofibrous scaffold, suggesting potential advantages for biomedical applications.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Nanoscience & Nanotechnology
Jun Liu, Siyu Wu, Jiayi Ma, Chun Liu, Ting Dai, Xiaoyu Wu, Hongbin Zhao, Dong Zhou
Summary: This study manufactured nanofibrous scaffolds incorporating different ratios of attapulgite (ATP) and Hydroxyapatite (HA) to enhance the osteoinductive effect in bone tissue engineering. The synergistic effect of ATP and HA on bone formation was explored both in vivo and in vitro. The study found that the ATP/HA ratio of 2:1 had the most significant synergistic effect.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Materials Science, Multidisciplinary
John P. Bradford, Bernabe Tucker, Gerardo Hernandez-Moreno, Phillip Charles, Vinoy Thomas
Summary: This study utilized low-temperature plasma to modify the surface of 3D printed poly(lactic acid) (PLA) for promoting mineralization, successfully detecting calcium phosphates on the polymer surfaces. The results suggest the futuristic potential of this surface modification method for bone tissue engineering applications.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kiran R. Adhikari, Inessa Stanishevskaya, Pablo C. Caracciolo, Gustavo A. Abraham, Vinoy Thomas
Summary: In this study, electrospun scaffolds based on a blend of PHH and PDO were characterized, showing high porosity and nanofiber structure. The mechanical properties of the blended scaffold, including elastic modulus, tensile strength, and maximum elongation, were comparable to materials currently used for soft tissue applications. This demonstrates the potential of electrospun PHH/PDO blend for cardiac patches or vascular graft applications mimicking native tissue.
Article
Materials Science, Multidisciplinary
Joseph A. Ayariga, Morgan Dean, Elijah Nyairo, Vinoy Thomas, Derrick Dean
Summary: This study investigated the effectiveness of combining 3D printing and electrospinning to create hybrid 3D scaffolds for stem cells differentiation into osteogenic lineage. The scaffolds mimicked the extracellular matrix in structure and bioactivity, providing inductive cues for cells. The incorporation of hydroxyapatite promoted cell attachment and differentiation, leading to bone tissue regeneration.
Article
Pharmacology & Pharmacy
Andrew F. Uehlin, Jeremy B. Vines, Dale S. Feldman, Elijah Nyairo, Derrick R. Dean, Vinoy Thomas
Summary: In this study, a biohybrid fibrous scaffold based on nanofibers was developed and shown to have improved mechanical properties suitable for ligament-replacement grafts. The use of NaOH treatment and the immobilization of fibrin enhanced the osteogenic differentiation of cells, leading to potential applications in tissue engineering.
Article
Nanoscience & Nanotechnology
Vineeth M. Vijayan, Melissa Walker, Renjith R. Pillai, Gerardo Hernandez Moreno, Yogesh K. Vohra, J. Jeffrey Morris, Vinoy Thomas
Summary: The paper reports a green low-temperature plasma-based in situ surface reduction strategy called plasma electroless reduction (PER) for achieving in situ metallic nanostructuring on polymer surfaces. The method was demonstrated on different polymer surfaces and showed excellent adaptability. Through optimization, uniform metallic nanoparticle-modified 3D printed scaffolds were obtained, improving cytocompatibility. The antibacterial efficacy of the silver coatings on face masks and 3D scaffolds was also demonstrated, indicating the potential of this method for biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Andrew F. Uehlin, Jeremy B. Vines, Dale S. Feldman, Derrick R. Dean, Vinoy Thomas
Summary: In this study, an inkjet-printed pattern of nanoparticulate hydroxyapatite (HANP) on a poly(lactic acid) (PLA) nanofiber scaffold was used to achieve a mineralized gradient over an ACL-subchondral bone interface. The combined addition of fibrin and HANP greatly enhanced osteogenic differentiation, with the cell morphology varying depending on HANP density.
Article
Nanoscience & Nanotechnology
Bria Storr, Luke Moore, Kallol Chakrabarty, Zaheeruddin Mohammed, Vijaya Rangari, Cheng-Chien Chen, Shane A. Catledge
Summary: Microwave-induced plasma was used to anneal precursor powders containing five metal oxides with carbon and boron carbide as reducing agents, resulting in the synthesis of high entropy boride ceramics with improved hardness and oxidation resistance.
Review
Pharmacology & Pharmacy
Mina Zare, Rakesh Pemmada, Maya Madhavan, Aswathy Shailaja, Seeram Ramakrishna, Sumodan Padikkala Kandiyil, James M. Donahue, Vinoy Thomas
Summary: This article reviews the design measures for siRNA delivery systems and potential siRNA and miRNA drug delivery systems for cancer treatment, including the use of various nanocarriers. The article highlights the challenges and obstacles in the clinical application of siRNA drugs and discusses strategies to improve the delivery efficiency of siRNA and miRNA through modification of nanocarriers.
Article
Nanoscience & Nanotechnology
Kallol Chakrabarty, Paul A. Baker, Vineeth M. Vijayan, Shane A. Catledge
Summary: In this study, cubic boron nitride (cBN) coatings were synthesized on diamond seeded silicon substrates using a microwave plasma chemical vapor deposition system. The effects of argon flow rate and bias voltage on the growth of cBN coatings were investigated. The results showed that energetic argon ions generated in the plasma significantly increased the cBN content in the coating.
Review
Polymer Science
Renjith Rajan Pillai, Vinoy Thomas
Summary: Recently, there has been significant attention towards natural and synthetic polymers as alternatives to non-renewable materials. Surface-modified natural fibers (NFs), polymers, and their derivatives have been extensively studied to reduce pollution and energy consumption. However, challenges in terms of durability, strength, and processing still exist for NFs. Low-temperature plasma (LTP) surface treatment has shown promise in tailoring surface properties of materials without affecting their bulk properties. This article provides an overview of the latest developments in surface engineering of NFs, polymers, and composites for diverse applications including environmental remediation, packaging, biomedical devices, and sensors.
Correction
Pharmacology & Pharmacy
Mina Zare, Rakesh Pemmada, Maya Madhavan, Aswathy Shailaja, Seeram Ramakrishna, Sumodan Padikkala Kandiyil, James M. Donahue, Vinoy Thomas
Article
Chemistry, Physical
Bria Storr, Carolina Amezaga, Luke Moore, Seth Iwan, Yogesh K. Vohra, Cheng-Chien Chen, Shane A. Catledge
Summary: Metal oxide thermal reduction using microwave-induced plasma was employed to synthesize high entropy borides (HEBs). The ability of the microwave plasma to efficiently transfer thermal energy in an argon-rich plasma facilitated the chemical reactions. The predominantly single-phase hexagonal AlB2-type HEBs were obtained by boro/carbothermal reduction and borothermal reduction. A comparison of microstructural, mechanical, and oxidation resistance properties revealed that HEBs synthesized with carbon exhibited reduced porosity, higher density, and higher hardness.
Article
Engineering, Biomedical
Chandrima Karthik, S. Rajalakshmi, Sabu Thomas, Vinoy Thomas
Summary: Low temperature plasma (LTP) process is a green method used to modify materials in various fields. It provides surface characteristics and tailored functionalities, enabling the fabrication of smart biomaterials. Plasma treatment is advantageous in functionalization and coating deposition, as it avoids the challenges of wet methods. Moreover, it is considered eco-friendly compared to conventional wet chemical processes.
CURRENT OPINION IN BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Vineeth M. Vijayan, Melissa Walker, J. Jeff Morris, Vinoy Thomas
Summary: This article discusses the importance of the design of material surfaces in medical devices and introduces some recent advances in infection mitigation strategies. It focuses on the material science and biological perspectives of biomaterial infection and corresponding mitigation strategies.
CURRENT OPINION IN BIOMEDICAL ENGINEERING
(2022)
Review
Materials Science, Biomaterials
Pranay Ranjan, Vinoy Thomas, Prashant Kumar
Summary: The COVID-19 pandemic has significantly impacted global economies and public health, posing immense challenges for many countries. Emerging 2D materials like graphene provide an effective platform for the diagnosis and treatment of SARS-CoV-2, offering promising solutions for the current crisis.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
