AKT inactivation causes persistent drug tolerance to EGFR inhibitors

标题

AKT inactivation causes persistent drug tolerance to EGFR inhibitors

作者

关键词

Non-small-cell lung cancer (NSCLC), Tyrosine kinase inhibitors (TKIs), Epidermal growth factor receptor (EGFR) inhibition, AKT protein kinase, Ets-1 transcription factor, Dual specificity phosphatase 6 (DUSP6), ERK1/2 paradoxical activation, Bcl-2 interacting protein Bim, Drug resistance, Drug tolerant persister cells, Gefitinib (Iressa), Erlotinib (Tarceva), Lapatinib (Tykerb), PD325901, Saracatinib (AZD0530)

出版物

PHARMACOLOGICAL RESEARCH

Volume 102, Issue -, Pages 132-137

出版商

Elsevier BV

发表日期

2015-10-23

DOI

10.1016/j.phrs.2015.09.022