Article
Polymer Science
Mengtian Sun, Yang Wang, Xiaowu Wang, Qiong Liu, Ming Li, Yury M. Shulga, Zhi Li
Summary: LDH/SA composites were prepared by an in-situ sol-gel process, and the introduction of MgAl-LDH significantly enhanced the thermal stability and safety of LDH/SA without impairing their mesoporous properties.
Article
Chemistry, Physical
Yoogyeong Kim, Yeongkyun Son, Sungjun Bae, Tae-Hyun Kim, Yuhoon Hwang
Summary: In this study, the chromate adsorption efficacy of MgAl-layered double hydroxide (LDH) was investigated. The results showed that Cl-intercalated LDH had a higher adsorption capacity compared to CO3-LDH, and fast chromate adsorption occurred within a short period of time. The crystal structure and morphology of LDH were well preserved after the adsorption, with most of the chromate ions being adsorbed on the surface. Additionally, LDH exhibited a high removal efficiency in practical applications.
APPLIED CLAY SCIENCE
(2022)
Article
Environmental Sciences
Aishah Mahpudz, Siu Ling Lim, Hitoshi Inokawa, Katsuki Kusakabe, Ryuichi Tomoshige
Summary: The study successfully synthesized a non-noble metal cobalt nanoparticle catalyst supported on layered double hydroxide, which showed efficient catalytic hydrolysis of sodium borohydride to produce hydrogen. The optimized size of cobalt nanoparticles enhanced catalytic activity, but the catalyst exhibited gradual decrease in activity during repeated tests.
ENVIRONMENTAL POLLUTION
(2021)
Review
Chemistry, Multidisciplinary
Ling-Xiao Zhang, Jing Hu, Ying-Bo Jia, Rui-Tian Liu, Ting Cai, Zhi Ping Xu
Summary: Layered double hydroxide (LDH) is a two-dimensional clay material with a unique structure that has shown potential for biomedical applications, with MgAl-LDH being identified as the most promising adjuvant for clinical use.
Article
Engineering, Chemical
Mingzhe Dong, Qinglong Luo, Jun Li, Kaiyuan Shi, Zhijian Wu, Jie Tang
Summary: Porous MgAl-layered double hydroxides (MgAl-LDHs) were synthesized by a sol-gel method and converted into LiAl-LDHs through a dissolution and recrystallization process. Both MgAl-LDHs and LiAl-LDHs showed high adsorption capacity and are promising for scalable lithium extraction from salt-lake brines.
MINERALS ENGINEERING
(2023)
Article
Engineering, Environmental
Liang Cai, Yuze Zhang, Xiaowu Peng, Fan Guo, Lianmin Ji, Lijuan Li
Summary: In this study, GA-LDH material was synthesized for borate acid adsorption and achieved a high adsorption capacity under optimized conditions, showing better adsorption performance compared to conventional materials. The research on adsorption mechanism and thermodynamics revealed the complex reaction process of boron adsorption by GA-LDH.
JOURNAL OF WATER PROCESS ENGINEERING
(2021)
Article
Chemistry, Physical
Sadegh Askari, Davide Mariotti, Paul Brunet, Alexander Vahl, Jan Benedikt
Summary: The hybrid Zn-air and Zn-M battery with Fe-doped Ni double hydroxide nanoflakes and activated carbon cathode material shows superior performance, high energy density, exceptional energy conversion efficiency, and outstanding power density. It also enables high-rate charging due to rapid redox reaction kinetics and excellent cathode materials catalytic activity.
MATERIALS TODAY ENERGY
(2021)
Article
Chemistry, Physical
Fanping Kong, Yuan Xie, Caifeng Xia, Hanhan Huang, Derui Liang, Yahui Qiu, Qian Zhang, Xinpeng Liu, Huaizhi Shao, Zilin Meng
Summary: Biochar supported Zn-Al-Fe layered double hydroxide (LDH@BC) was synthesized for efficient removal of H2S. The LDHs grew uniformly on the surface of BC and formed a porous structure, enabling better gas passage. The optimized LDH@BC composite exhibited over 80% removal efficiency for H2S at a concentration of 1000 mg/m(3) and temperature of 180C.
SURFACES AND INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
V. K. Ameena Shirin, Renu Sankar, Asha P. Johnson, H. V. Gangadharappa, K. Pramod
Summary: Layered double hydroxides (LDHs) are nanomaterials with high surface-to-volume ratio, suitable for drug delivery applications. Interlayered drugs can be released in a sustained manner, reducing drug administration frequency.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Applied
Xue Bai, Zhiyao Duan, Bing Nan, Liming Wang, Tianmi Tang, Jingqi Guan
Summary: This study presents a facile method for synthesizing ultrathin CoFe-based LDHs and reveals their high performance in OER. The Co site is identified as the main active center, and the doping of Fe accelerates the charge-transfer process. Surface Co sites are found to be the active centers for OER, while excessive subsurface Fe doping weakens OH* adsorption and increases the energy barrier of the rate-determining step.
CHINESE JOURNAL OF CATALYSIS
(2022)
Article
Energy & Fuels
Yezeng He, Didi Liu, Houqiang Zhao, Jiemei Wang, Yanwei Sui, Jiqiu Qi, Zheng Chen, Ping Zhang, Changjiu Chen, Dongdong Zhuang
Summary: The study successfully prepared C/NiMn-LDH/Ni3S2 electrode material, which maintained a high capacitance even after 5000 cycles, and the two-electrode device assembled with activated carbon showed excellent specific energy.
JOURNAL OF ENERGY STORAGE
(2021)
Article
Chemistry, Physical
Antonio J. S. Fernandes Junior, Welton C. Sodre, Barbara E. C. F. Soares, Cicero W. B. Bezerra, Alex Rojas, Javier Perez-Carvajal, Ana C. S. Alcantara
Summary: Global concerns over the future consequences of uncontrolled industrial development have led to the emergence of sustainable materials composed of earth abundant elements. A new type of heterostructured material has been synthesized by assembling inexpensive metals on synthetic silicates, showing promising performance in catalytic reactions. The study indicates that the presence of particular metal-oxide nanoparticles supported on specific materials can enhance photocatalytic activity and stability.
APPLIED SURFACE SCIENCE
(2021)
Article
Immunology
Iriane Marques de Carvalho, Ana Beatriz Farias de Souza, Thalles de Feitas Castro, Pedro Alves Machado-Junior, Tatiana Prata Menezes, Andreia da Silva Dias, Laser Antonio Machado Oliveira, Katiane de Oliveira Pinto Coelho Nogueira, Andre Talvani, Silvia Dantas Cangussu, Gregorio Guadalupe Carbajal Arizaga, Frank Silva Bezerra
Summary: Lycopene is a natural compound with high antioxidant activity and has been associated with lower risks in lung cancer and chronic obstructive pulmonary disease. A study found that the ingestion of lycopene reduced lung damage caused by cigarette smoke in a mouse model. The researchers developed a lycopene layered double hydroxide (Lyc-LDH) composite that can transport lycopene in aqueous media. The study investigated the cytotoxicity of Lyc-LDH and its effect on reactive oxygen species (ROS) production in cells, as well as conducted in vivo assays in mice. The results showed that high concentrations of Lyc-LDH induced inflammation and redox status changes in the lungs, while low concentrations showed potential as a vehicle for intranasal administration of antioxidant coadjuvants.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Energy & Fuels
Yu-Cheng Hsiao, Chen-Hao Liao, Chia-Shuo Hsu, Sibidou Yougbar, Lu-Yin Lin, Yung-Fu Wu
Summary: In this study, manganese cobalt layered double hydroxide (MnCo-LDH) was incorporated into sulfur-doped NiCo-LDH (S-NiCo-LDH) on a nickel foam (NF) substrate via a hydrothermal process. The resulting composite exhibited a favorable morphology with high specific surface area and well-established pore structure, leading to a specific capacitance of 1581.3 F/g. When incorporated into a battery super-capacitor hybrid, the MnCo-LDH/S-NiCo-LDH composite demonstrated a wide potential window, high energy density, and excellent cyclic stability.
JOURNAL OF ENERGY STORAGE
(2023)
Review
Materials Science, Multidisciplinary
L. Yang, Z. Liu, S. Zhu, L. Feng, W. Xing
Summary: This review comprehensively summarizes recent developments of Ni-based layered double hydroxides (LDHs) in oxygen evolution reaction (OER), including fabrication strategies, electrocatalyst applications, and structural modifications. It identifies obstacles hindering the practical use of Ni-based LDHs and emphasizes the need for more research in structural rational design and application in real water electrolysis techniques.
MATERIALS TODAY PHYSICS
(2021)
Article
Chemistry, Physical
Sanoj N. Rejinold, Goeun Choi, Huiyan Piao, Jin-Ho Choy
Summary: COVID-19 has highlighted the importance of developing new medications to combat the ongoing pandemic. Repurposing existing drugs, such as niclosamide, and using Zein nanoparticles coated with bovine serum albumin (BSA) to encapsulate the drug shows promise in improving drug stability and effectiveness in fighting the SARS-CoV-2 virus. The hybrid drug delivery system demonstrated smaller particle size, excellent colloidal stability, sustained drug release properties, and enhanced drug release behavior under serum conditions, which could be beneficial in treating severe COVID-19 patients with endothelial glycocalyx damage and cytokine storm related inflammations.
Article
Chemistry, Physical
N. Sanoj Rejinold, Huiyan Piao, Goeun Choi, Geun-Woo Jin, Jin-Ho Choy
Summary: The COVID-19 pandemic has affected millions worldwide, leading to a need for effective medication. Combining vaccination with antiviral drugs is crucial to combat new variants. Repurposing FDA-approved drugs like niclosamide and utilizing advanced nano-pharmaceutical approaches show promise in improving treatment outcomes.
CLAYS AND CLAY MINERALS
(2021)
Review
Biochemistry & Molecular Biology
N. Sanoj Rejinold, Goeun Choi, Jin-Ho Choy
Summary: Clay-based bio-inorganic nanohybrids, such as layered double hydroxides (LDH), have been extensively researched in the field of biomedicine for drug delivery and bio-imaging applications. Recent trends show that these materials can be hybridized with photo-active biomolecules to achieve selective anti-cancer effects through various photo/chemotherapies. The use of LDH enhances the stability and controllability of the therapies, improving overall phototherapeutic performance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Seungjin Yu, Huiyan Piao, N. Sanoj Rejinold, Hanna Lee, Goeun Choi, Jin-Ho Choy
Summary: By designing a new inorganic-organic nanohybrids system, we have improved the efficacy of nicotinic acid and reduced the associated side effects.
Article
Polymer Science
Hyeon-Ju Ryu, Nguyen Thu Hang, Sanoj N. Rejinold, Byeongmoon Jeong, Goeun Choi, Jin-Ho Choy
Summary: Nanocomposites of hydrophobic organo-clay/polypropylene were efficiently developed through a solution-blending technique. Among the various clays used, CTA-Mica showed the best improvement in both thermal stability and mechanical properties of the PP nanocomposites compared to CTA-Mt and CTA-Ht.
Review
Biochemistry & Molecular Biology
Geun-Woo Jin, N. Sanoj Rejinold, Jin-Ho Choy
Summary: Polyphosphazenes (PPZs), with their structural flexibility and biodegradability, have attracted great interest as synthetic polymers in the field of biomedical science. The introduction of various functional groups has enabled the development of multi-functionalized PPZs, which have shown potential as biomaterials in the form of nanoparticles (NPs) and hydrogels for various applications such as drug delivery, bioimaging, phototherapy, bone regeneration, and dental liners.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Polymer Science
Geun-Woo Jin, N. Sanoj Rejinold, Jin-Ho Choy
Summary: Polymeric micelles, as carriers for therapeutic compounds, have attracted attention due to their ability to solubilize poorly water-soluble drugs, biocompatibility, and accumulation in tumors. Additional functionality can be achieved through surface modification and stimuli-sensitive groups. This review highlights the development of multifunctional polymeric micelles in cancer therapy, including applications in tumor imaging and theragnosis.
Article
Materials Science, Biomaterials
Geun-Woo Jin, Goeun Choi, Huiyan Piao, N. Sanoj Rejinold, Shunsuke Asahina, Soo-Jin Choi, Hwa Jeong Lee, Jin-Ho Choy
Summary: Cancer therapies currently consist of surgery, radiation, chemotherapy, targeted therapy, and immunotherapy. Researchers have developed a new compound called polytaxel (PTX) that can potentially replace existing therapies by offering high anticancer efficacy and 100% survival rate without side effects. Proof-of-concept studies conducted on pancreatic cancer models showed that PTX inhibited tumors similarly to the commonly used drug docetaxel (DTX), but without the associated toxic side effects.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Chemistry, Multidisciplinary
Seungjin Yu, Goeun Choi, Jin-Ho Choy
Summary: Two-dimensional nanomaterials, especially layered double hydroxides (LDHs), have found extensive applications in biomedical field due to their biocompatibility, biodegradability, controllable drug release/loading ability, and enhanced cellular permeability. This review summarizes the synthetic strategies and therapeutic actions of single-function LDH-based nanohybrids, as well as the recently developed multifunctional systems for drug delivery and bio-imaging (from 2019 to 2023).
Article
Biophysics
Sanoj N. Rejinold, Huiyan Piao, Goeun Choi, Jin-Ho Choy
Summary: Rationally designed 100 nm sized curcumin loaded exfoliated layered double hydroxide nanoparticles (X-LDH/CRC-NPs) have been tested for their efficacy in treating non-small cell lung cancer (NSCLC) cell lines, resulting in increased apoptosis. Preclinical evaluation on a nude mouse model with A549 tumor confirmed the potential of X-LDH/CRC-NPs as a highly advantageous treatment for lung cancers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Goeun Choi, N. Sanoj Rejinold, Huiyan Piao, Young Bae Ryu, Hyung-Jun Kwon, In Chul Lee, Jeong In Seo, Hye Hyun Yoo, Geun-woo Jin, Jin-Ho Choy
Summary: The COVID-19 pandemic requires new orally administrable antiviral agents. The engineering of hydrophilic NIC-MgO-HPMC improves intestinal permeability and inhibits SARS-CoV-2 replication.
Article
Materials Science, Biomaterials
Ji-Yeong Kim, Hyun-Il Shin, Sang-Eun Lee, Huiyan Piao, N. Sanoj Rejinold, Goeun Choi, Jin-Ho Choy
Summary: Artesunic acid (AS(0)), a derivative of artemisinin, is a recommended drug for severe malaria treatment, but its use is limited. This study explores a novel 2D inorganic delivery system for AS(0) by immobilizing it into metal hydroxides to target red blood cells (RBCs). The results show that the nanohybrid drugs are haemo-compatible and effectively target RBCs. The antimalarial effect of these nanohybrids is 6 times more effective than intact AS(0). Therefore, the nanohybrids with haemo-compatible carriers could be a promising drug delivery system for malarial treatment.
BIOMATERIALS SCIENCE
(2022)
Article
Materials Science, Biomaterials
Sairan Eom, Min Hwan Kim, Ranji Yoo, Goeun Choi, Joo Hyun Kang, Yong Jin Lee, Jin-Ho Choy
Summary: In this study, Cu-64-QT-NPs were successfully prepared by directly immobilizing Cu-64 radioisotope in the quintinite lattice. The labeled nanoparticles showed high stability and passive targeting into tumor tissue based on the enhanced permeability and retention (EPR) effect. Coating bovine serum albumin (BSA) further improved the tumor tissue selectivity of Cu-64-QT-NPs.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Chemistry, Multidisciplinary
Goeun Choi, N. Sanoj Rejinold, Huiyan Piao, Jin-Ho Choy
Summary: Advanced nanotechnology is rapidly advancing in the field of novel hybrid nanomaterials, with materials like gold, iron, and silica showing great potential in biomedical applications. Recent research also indicates the promising use of up-conversion nanomaterials in treating deep-seated tumor tissues.
Review
Nanoscience & Nanotechnology
Goeun Choi, Jin-Ho Choy
Summary: LDH, as a nanomaterial, can serve as a biocompatible drug delivery vehicle for cancer chemotherapy and also as diagnostic and imaging agents. This article summarizes the theranostic functions of drug-LDH hybrid nanoparticles, including their synthetic methods, physico-chemical and biological properties, and unique mechanisms for overcoming drug resistance and targeting properties based on in vitro and in vivo results.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)