Review
Cardiac & Cardiovascular Systems
Xiaoqing Peng, Ruirui Hou, Yuanyuan Yang, Zhigang Luo, Yunxia Cao
Summary: This article discusses the role and current research status of mitochondrial quality control (mQC) in placental-originated preeclampsia (PE), and provides suggestions for future research, aiming to provide new ideas for the development of prevention and treatment strategies for PE.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Xing Chang, Ruxiu Liu, Ruibing Li, Youyou Peng, Pingjun Zhu, Hao Zhou
Summary: Ischemic cardiomyopathy (ICM) is a type of coronary heart disease that is related to the pathological mechanism of primary dilated cardiomyopathy. ICM is mainly caused by long-term myocardial ischemia and results in diffuse myocardial fibrosis, affecting the cardiac ejection function. The pathogenesis of ICM involves inflammation, myocardial hypertrophy, fibrosis, and vascular remodeling, with mitochondrial quality control (MQC) playing an important role.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Xing Chang, Ruxiu Liu, Ruibing Li, Youyou Peng, Pingjun Zhu, Hao Zhou
Summary: Ischemic cardiomyopathy (ICM) is a type of coronary heart disease that occurs in the long-term myocardial ischemia, leading to diffuse myocardial fibrosis. The pathogenesis of ICM is closely related to coronary heart disease, mainly caused by coronary stenosis or vascular occlusion. Mitochondrial Quality Control (MQC) plays an important role in regulating mitochondrial function in cardiomyocytes and affects the morphological structure/function and lifespan of mitochondria. This review discusses the role of MQC in the pathogenesis of ICM and provides important evidence for targeting MQC for ICM.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Neurosciences
Gee Euhn Choi, Ho Jae Han
Summary: Mitochondrial dysfunction can lead to neuropathologies, while chronic exposure to high levels of glucocorticoids exacerbates mitochondrial dysfunction and contributes to the progression of neurodegenerative diseases.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Cell Biology
Wenni Dai, Hengcheng Lu, Yinyin Chen, Danyi Yang, Lin Sun, Liyu He
Summary: Diabetic kidney disease is a major complication of diabetes mellitus, with a complex pathogenesis involving inflammation, autophagy impairment, and oxidative stress. The loss of mitochondrial quality control plays a critical role in the progression of DKD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Srimanta Patra, Kewal Kumar Mahapatra, Prakash Priyadarshi Praharaj, Debasna Pritimanjari Panigrahi, Chandra Sekhar Bhol, Soumya Ranjan Mishra, Bishnu Prasad Behera, Amruta Singh, Mrutyunjay Jena, Sujit Kumar Bhutia
Summary: Mitochondrial Ca2+ plays a crucial role in maintaining cellular homeostasis by regulating mitochondrial dynamics, mitophagy, and mitochondrial biogenesis, while dysregulation of mitochondrial Ca2+ can lead to various pathological conditions, including cancer. This review discusses the interaction between mitochondrial Ca2+ and quality control, highlighting their importance in governing mitochondrial health and coordination in cancer development.
Review
Biochemistry & Molecular Biology
Guo-Yan Sui, Feng Wang, Jin Lee, Yoon Seok Roh
Summary: This review focuses on the role of mitochondria in inflammatory bowel disease and colorectal cancer, as well as the mechanisms by which mitochondrial dysfunction leads to abnormal activation of inflammatory signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Lei Chen, Yuan Qin, Bilin Liu, Meng Gao, Anqi Li, Xue Li, Guohua Gong
Summary: Mitochondria with structural and functional integrity are crucial for maintaining cardiac homeostasis, and peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) plays a key role in this process. PGC-1 alpha regulates mitochondrial biogenesis, dynamics, and mitophagy, which are essential for the onset and progression of heart failure.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tanuja Ambekar, Jyoti Pawar, Ramdev Rathod, Monica Patel, Valencia Fernandes, Rahul Kumar, Shashi Bala Singh, Dharmendra Kumar Khatri
Summary: Mitochondria play a crucial role in cellular stress response, energy metabolism, and cell survival, and maintaining mitochondrial quality control is essential for homeostasis. Pathological conditions disrupt this control, contributing to neurodegenerative diseases. Therapeutic approaches targeting mitochondrial quality control have shown promising effects in ameliorating these diseases.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Review
Cell Biology
Heyan Tian, Xiangyu Chen, Jun Liao, Tong Yang, Shaowu Cheng, Zhigang Mei, Jinwen Ge
Summary: Mitochondrial quality control plays a critical role in stroke by preserving mitochondrial structure and function, promoting neuronal survival, and alleviating pathological processes.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Oncology
Hui Tian, Dafei Chai, Gang Wang, Qiping Wang, Nan Sun, Guan Jiang, Huizhong Li, Jingyuan Song, Lin Fang, Meng Wang, Zengli Guo, Junnian Zheng
Summary: Metabolic stress in the tumor microenvironment can inhibit T cell activity, but the mitochondrial protein C1QBP is crucial for maintaining mitochondrial integrity and homeostasis in T cells, enhancing their antitumor immunity.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Endocrinology & Metabolism
Hong An, Bing Zhou, Xunming Ji
Summary: Mitochondria play a central role in the pathophysiological processes of acute ischemic stroke by responding to disruptions in oxygen and glucose delivery through activating various quality control mechanisms. Understanding these regulatory pathways can help in developing innovative neuroprotectants for acute ischemic stroke when these mechanisms fail.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Nutrition & Dietetics
Hengfang Tang, Zhiming Zheng, Han Wang, Li Wang, Genhai Zhao, Peng Wang
Summary: Vitamin K2 can alleviate neuronal cell death mediated by mitochondrial damage by regulating the mitochondrial quality-control loop and repairing mitochondrial dysfunction.
Review
Multidisciplinary Sciences
LiuSong Wang, Zan Jie Feng, Xuan Ma, Kai Li, Xin Yao Li, Yi Tang, Cijun Peng
Summary: Hepatic ischemia-reperfusion injury occurs during liver surgery and transplantation, causing worsened damage to liver cells due to restored blood flow. Mitochondria play a critical role in cell survival and apoptosis, and disruptions to mitochondrial quality control mechanisms, such as reduced autophagy and fusion, contribute to the dysfunction of the mitochondrial network and subsequent apoptosis of hepatocytes. Current research aims to protect against hepatic ischemia-reperfusion injury by targeting mitochondrial quality control mechanisms through drug pretreatment, stem cells and exosomes, genetic interventions, and mechanical reperfusion.
Review
Biochemistry & Molecular Biology
Giovanni Fajardo, Michael Coronado, Melia Matthews, Daniel Bernstein
Summary: Alterations in mitochondrial function and morphology are critical adaptations to cardiovascular stress, working in concert in an attempt to restore organelle-level and cellular-level homeostasis. Processes that alter mitochondrial morphology include fission, fusion, mitophagy, and biogenesis, and these interact to maintain mitochondrial quality control. Both pathological stressors like ischemia and physiological stressors like aerobic exercise can induce morphologic adaptations in mitochondria, but with different outcomes for mitochondrial health. Understanding the mechanisms underlying alterations in mitochondrial quality control under diverse cardiovascular stressors can aid in developing pharmacologic interventions for restoring cellular homeostasis.
Article
Biochemistry & Molecular Biology
Flavie Strappazzon, Anthea Di Rita, Angelo Peschiaroli, Pier Paolo Leoncini, Franco Locatelli, Gerry Melino, Francesco Cecconi
CELL DEATH AND DIFFERENTIATION
(2020)
Correction
Biochemistry & Molecular Biology
Flavie Strappazzon, Anthea Di Rita, Angelo Peschiaroli, Pier Paolo Leoncini, Franco Locatelli, Gerry Melino, Francesco Cecconi
CELL DEATH AND DIFFERENTIATION
(2020)
Editorial Material
Cell Biology
Sos Gronbaek Holdgaard, Valentina Cianfanelli, Francesco Cecconi
Editorial Material
Biochemistry & Molecular Biology
Francesco Cecconi
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Biochemistry & Molecular Biology
Anthea Di Rita, Teresa Maiorino, Krenare Bruqi, Floriana Volpicelli, Gian Carlo Bellenchi, Flavie Strappazzon
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Luca Simula, Mauro Corrado, Benedetta Accordi, Anthea Di Rita, Francesca Nazio, Ylenia Antonucc, Arianna Di Danie, Federico Caicci, Ignazio Caruana, Maria Eugenia Soriano, Martina Pigazzi, Franco Locatelli, Francesco Cecconi, Silvia Campello
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Developmental Biology
Giacomo Meneghetti, Tatjana Skobo, Martina Chrisam, Camilla Maria Fontana, Nicola Facchinello, Francesca Nazio, Francesco Cecconi, Paolo Bonaldo, Luisa Dalla Valle
Article
Cell Biology
Alfonso Schiavi, Flavie Strappazzon, Natascia Ventura
MECHANISMS OF AGEING AND DEVELOPMENT
(2020)
Article
Genetics & Heredity
Marina Macchiaiolo, Paola Sabrina Buonuomo, Gerarda Mastrogiorgio, Matteo Bordi, Beatrice Testa, Gerrit Weber, Emanuele Bellacchio, Marco Tartaglia, Francesco Cecconi, Andrea Bartuli
MOLECULAR GENETICS AND METABOLISM REPORTS
(2020)
Article
Cell Biology
Katharina Bell, Ines Rosignol, Elena Sierra-Filardi, Natalia Rodriguez-Muela, Carsten Schmelter, Francesco Cecconi, Franz Grus, Patricia Boya
CELL DEATH DISCOVERY
(2020)
Review
Biochemistry & Molecular Biology
Daniel J. Klionsky, Giulia Petroni, Ravi K. Amaravadi, Eric H. Baehrecke, Andrea Ballabio, Patricia Boya, Jose Manuel Bravo-San Pedro, Ken Cadwell, Francesco Cecconi, Augustine M. K. Choi, Mary E. Choi, Charleen T. Chu, Patrice Codogno, Maria Isabel Colombo, Ana Maria Cuervo, Vojo Deretic, Ivan Dikic, Zvulun Elazar, Eeva-Liisa Eskelinen, Gian Maria Fimia, David A. Gewirtz, Douglas R. Green, Malene Hansen, Marja Jaattela, Terje Johansen, Gabor Juhasz, Vassiliki Karantza, Claudine Kraft, Guido Kroemer, Nicholas T. Ktistakis, Sharad Kumar, Carlos Lopez-Otin, Kay F. Macleod, Frank Madeo, Jennifer Martinez, Alicia Melendez, Noboru Mizushima, Christian Munz, Josef M. Penninger, Rushika M. Perera, Mauro Piacentini, Fulvio Reggiori, David C. Rubinsztein, Kevin M. Ryan, Junichi Sadoshima, Laura Santambrogio, Luca Scorrano, Hans-Uwe Simon, Anna Katharina Simon, Anne Simonsen, Alexandra Stolz, Nektarios Tavernarakis, Sharon A. Tooze, Tamotsu Yoshimori, Junying Yuan, Zhenyu Yue, Qing Zhong, Lorenzo Galluzzi, Federico Pietrocola
Summary: Autophagy is crucial for maintaining cellular and organismal homeostasis, and dysfunction in autophagy is implicated in the pathogenesis of major human disorders across various organ systems.
Editorial Material
Cell Biology
Emiliano Maiani, Giacomo Milletti, Francesco Cecconi
Summary: AMBRA1 is a key scaffold protein that regulates early autophagosome formation, cell growth, and G1/S phase transition, and its deficiency is associated with neurodevelopmental defects and cancer. By controlling the expression of D-type cyclins, AMBRA1 plays a crucial role in maintaining genome integrity during DNA replication and represents a novel mechanism of cell cycle regulation interconnected with genomic stability in development and cancer.
Article
Cell Biology
Matteo Bordi, Rossella De Cegli, Beatrice Testa, Ralph A. Nixon, Andrea Ballabio, Francesco Cecconi
Summary: The study compiled a comprehensive list of 604 genes involved in the autophagy pathway, categorizing them into main groups and sub-groups based on their functions and sub-cellular localization. They also curated shorter sub-lists for predicting autophagy activation and lysosomal biogenesis, and validated some transcriptional targets using Real-time PCR. The authors demonstrated the utility of their autophagy gene list in RNA-sequencing analysis.
CELL DEATH & DISEASE
(2021)
