Article
Biophysics
Bhavya Surekha, Naga Sreenu Kommana, Sunil Kumar Dubey, A. V. Pavan Kumar, Rahul Shukla, Prashant Kesharwani
Summary: PAMAM dendrimers are novel polymeric structures with defined nano-size and multiple active functional groups, ideal for cancer therapy. Their modifiable surface functionalities and high drug encapsulation rate make them widely used in drug delivery and gene therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Polymer Science
Mohammad Nikzamir, Younes Hanifehpour, Abolfazl Akbarzadeh, Yunes Panahi
Summary: Dendrimers are hyper-branched organic compounds with functional groups on the surface that can be modified for enhanced functionality. They possess unique properties such as nanoscale size, globular shape, high reactivity, and water solubility, making them promising for drug delivery applications. Dendrimers can serve as carriers for therapeutic agents, reducing drug toxicity and increasing efficacy, and have received significant attention from researchers in the field of nanomedicine.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2021)
Article
Engineering, Biomedical
Le Thi Thuy, Minyoung Choi, Minhyung Lee, Joon Sig Choi
Summary: Improving the transfection efficiency of non-viral carriers using cationic polymers like PAMAM G2-HRChol is a promising approach in gene therapy. These polymers have functional groups that enhance DNA condensation and cellular uptake, leading to improved endosomal escape and lower cytotoxicity compared to other carriers like PEI 25 kDa. Cholesterol incorporation in PAMAM G2-HRChol further enhances the gene transfection efficiency, making it a potential gene carrier in HeLa cells.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2022)
Article
Biochemistry & Molecular Biology
Seongyeon Kim, Le Thi Thuy, Jeil Lee, Joon Sig Choi
Summary: In this study, RRHRH oligopeptide was successfully conjugated to the surface of PAMAM G2, forming RRHRH-PAMAM G2 for gene delivery. The results showed that RRHRH-PAMAM G2 had small nanoparticle size, positive charge, high transfection efficiency, and biocompatibility with cell lines, indicating its potential as a gene carrier for gene therapy.
Article
Polymer Science
Shreyas Mukherjee, Samrat Mukherjee, Mohammed A. S. Abourehab, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Dendrimers, as a novel drug delivery system, play an important role in cancer immunotherapy. They have various properties and functions, forming high-specificity bonds with different functional groups. However, the increasing toxicity of newer generations of dendrimers can be mitigated through the attachment of anionic or neutral ligand groups.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
O. Karatas, R. Keyikoglu, N. Atalay Gengec, V. Vatanpour, A. Khataee
Summary: Membrane fouling is a major limitation in membrane technologies, but dendrimers have attracted wide interest for their unique chemical and structural properties. Various modification methods, especially using polyamidoamine dendrimers, have improved the separation performance, selectivity, and antifouling properties of membranes. The use of different nanomaterials in membrane modifications, along with dendrimers, offers prospects for development while also presenting key challenges.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jiamin Ban, Sidi Li, Qi Zhan, Xuepin Li, Huike Xing, Ning Chen, Lixia Long, Xin Hou, Jin Zhao, Xubo Yuan
Summary: The study demonstrates the use of PMPC-modified PAMAM nanoparticles as a drug delivery system for glioma treatment, showing that PMPC can reduce toxicity and effectively target brain tumors.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Michal Gorzkiewicz, Monika Marcinkowska, Maciej Studzian, Iwona Karwaciak, Lukasz Pulaski, Barbara Klajnert-Maculewicz
Summary: This study developed an innovative nanocarrier based on PAMAM dendrimer to increase the concentration of mesalazine in intestinal epithelial cells, thereby enhancing its anti-inflammatory potential. The covalent PAMAM-mesalazine conjugate was synthesized and characterized, and it was found that the drug successfully attached to the dendrimer. The use of PAMAM as a carrier improved cellular uptake and anti-inflammatory activity of mesalazine.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Medicine, Research & Experimental
Shugo Yamashita, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto
Summary: The aim of this study was to develop a new drug carrier for the treatment of bone diseases using a polyethylene glycol (PEG)-conjugated polyamidoamine dendrimer (PAMAM). The results showed that the carrier could efficiently target the osteoid surfaces and exhibit excellent performance in bone pathogenesis mechanisms.
MOLECULAR PHARMACEUTICS
(2022)
Article
Polymer Science
Reza Pashaei-Sarnaghi, Faezeh Najafi, Ameneh Taghavi-Kahagh, Mehdi Salami-Kalajahi, Hossein Roghani-Mamaqani
Summary: In this study, poly(amidoamine) dendrimer with ethylenediamine core up to the fourth generation was synthesized and conjugated to different amounts of 7-(carboxymethoxy)-4-methylcoumarin. Under UV light irradiation, the crosslinked dendrimer-coumarin samples showed smaller particle sizes compared to non-crosslinked samples, with release behavior being influenced by increasing coumarin moieties.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Physical
Jia-Si Wu, Jia-Xian Li, Na Shu, Qi-Jia Duan, Qi-Song Tong, Jing-Yang Zhang, Yong-Cong Huang, Si-Yu Yang, Zhi-Bin Zhao, Jin-Zhi Du
Summary: The study developed a novel polymer capable of polarizing TAMs into M1 phenotype, which efficiently loaded TLR7/8 agonist to remodel the tumor immunosuppressive microenvironment, enhancing the efficacy of cancer immunotherapy.
Article
Chemistry, Multidisciplinary
Orlagh M. Feeney, Katie Ardipradja, Ka Fung Noi, Dharmini Mehta, Robert De Rose, Daniel Yuen, Angus P. R. Johnston, Lee Kingston, Cecilia Ericsson, Charles S. Elmore, Richard Hufton, David J. Owen, Marianne B. Ashford, Christopher J. H. Porter
Summary: This study investigates the impact of subcutaneous dosing on lymphatic exposure, pharmacokinetics, and efficacy of AZD0466. The results show that subcutaneous dosing leads to longer half-life, higher lymphatic transport rate, and improved tolerance. Additionally, higher doses of subcutaneous administration result in improved efficacy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Polymer Science
Virali Arora, Mohammed A. S. Abourehab, Gyan Modi, Prashant Kesharwani
Summary: Dendrimers are synthetic nano-molecules with a spherical structure and a stardust topology. They are effective in solving the solubility problem in drug delivery and have been successfully used in chemotherapeutic drug delivery. Research has shown that dendrimers have potential in treating lung cancer and outperform other nanoparticles in terms of bioavailability and stability.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Silvia Sonzini, Fanny Caputo, Dora Mehn, Luigi Calzolai, Sven Even Borgos, Astrid Hyldbakk, Kevin Treacher, Weimin Li, Mark Jackman, Najet Mahmoudi, M. Jayne Lawrence, Claire Patterson, David Owen, Marianne Ashford, Nadim Akhtar
Summary: A comprehensive understanding of the key properties of drug-dendrimer conjugates is crucial for defining their critical quality attributes that impact drug product performance. However, characterizing the physicochemical properties, stability, and interaction with the biological environment of complex drug-dendrimer conjugates is challenging due to a limited number of established methods. In this study, a state-of-the-art multi-step approach was employed to fully characterize AZD0466, a drug-dendrimer conjugate under clinical development, highlighting the importance of using complementary techniques to measure stability in both simple and biological media.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Chunling Wang, Junchao Xu, Yinlong Zhang, Guangjun Nie
Summary: Abnormal angiogenesis is a significant characteristic of malignant tumors, and nanomedicine provides a precise approach to regulate tumor blood vessels. Nanomedicines have the advantage of reducing systemic toxicity and enhancing therapeutic efficacy, as well as enabling more precise drug delivery and release through specific structural designs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Medicine, Research & Experimental
Negar Taghavi Pourianazar, Ufuk Gunduz
BIOMEDICINE & PHARMACOTHERAPY
(2016)
Article
Pharmacology & Pharmacy
Negar Taghavi Pourianazar, Ufuk Gunduz
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2016)
Article
Cell & Tissue Engineering
Maryam Parsian, Pelin Mutlu, Negar Taghavi Pourianazar, Serap Yalcin Azarkan, Ufuk Gunduz
Summary: This paper presents a novel approach using magnetic nanoparticles (MNPs) and poly-amidoamine (PAMAM) dendrimers to fabricate a nanoscale drug delivery system for Palbociclib. The system effectively targets tumors and reduces systemic toxicity and drug resistance. In vitro experiments show that PAL-DcMNPs treatment significantly increases cell toxicity in breast cancer cell lines, suggesting its potential use in breast cancer treatment.
CELLULAR AND MOLECULAR BIOENGINEERING
(2023)
Article
Biology
Pelin Mutlu, Serap Yalcin Azarkan, Negar Taghavi Pourianazar, Meral Yucel, Ufuk Gunduz
Meeting Abstract
Biochemistry & Molecular Biology
S. Yalcin, P. Mutlu, G. Unsoy, M. Parsian, N. Taghavi Pourianazar, U. Gunduz
Meeting Abstract
Biochemistry & Molecular Biology
S. Yalcin, G. Unsoy, N. Taghavi Pourianazar, U. Gunduz
Meeting Abstract
Biochemistry & Molecular Biology
S. Yalcin, G. Unsoy, P. Mutlu, R. Khodadust, N. Taghavi Pourianazar, M. Parsian, U. Gunduz
Meeting Abstract
Biochemistry & Molecular Biology
G. Unsoy, S. Yalcin, R. Khodadust, P. Mutlu, N. Taghavi Pourianazar, U. Gunduz
Meeting Abstract
Biochemistry & Molecular Biology
G. Unsoy, R. Khodadust, S. Yalcin, P. Mutlu, N. Taghavi Pourianazar, M. Parsian, U. Gunduz
Meeting Abstract
Biochemistry & Molecular Biology
N. Taghavi Pourianazar, M. Parsian, G. Unsoy, S. Yalcin, U. Gunduz
Meeting Abstract
Biochemistry & Molecular Biology
N. Taghavi PourianAzar, U. Gunduz
Meeting Abstract
Biochemistry & Molecular Biology
M. Parsian, G. Unsoy, P. Mutlu, S. Yalcin, N. Taghavi PourianAzar, U. Gunduz
Meeting Abstract
Biochemistry & Molecular Biology
M. Parsian, N. Taghavi PourianAzar, S. Yalcin, P. Mutlu, U. Gunduz