Nanoengineered mesoporous silica nanoparticles for smart delivery of doxorubicin

The motive of the at hand exploration was to contrive a proficient innovative pH-responsive nanocarrier designed for an anti-neoplastic agent that not only owns competent loading capacity but also talented to liberate the drug at the specific site. pH sensitive hollow mesoporous silica nanoparticles (similar to MSN) have been synthesized by sequence of chemical reconstruction with an average particle size of 120 nm. similar to MSN reveal noteworthy biocompatibility and efficient drug loading magnitude. Active molecules such as Doxorubicin (DOX) can be stocked and set free from the pore vacuities of similar to MSN by tuning the pH of the medium. The loading extent of similar to MSN was found up to 81.4 wt% at pH 7.8. At mild acidic pH, DOX is steadily released from the pores of similar to MSN. Both, the nitrogen adsorption-desorption isotherms and X-ray diffraction patterns reflects that this system holds remarkable stable mesostructure. Additionally, the outcomes of cytotoxicity assessment further establish the potential of similar to MSN as a relevant drug transporter which can be thought over an appealing choice to a polymeric delivery system.