Article
Agricultural Engineering
Karine Modolon Zepon, Caroline do Amaral Fetzner Pucci, Alana Witt Hansen, Fernanda Mendes de Moraes, do Nascimento Jose Heriberto Oliveria, Fernando Dal Pont Morisso, Rachel Faverzani Magnago, Ana Luiza Ziulkoski
Summary: This study proposes using maltose and lactose as reducing and cryoprotectant agents to improve the long-term stability of silver nanoparticles (AgNPs). The sugars can act as reducing and capping agents of the synthesized AgNPs, and prevent aggregation under freezing and freeze-drying. The freeze-dried AgNPs showed more stability and maintained their antibacterial and cytotoxic activities, making maltose and lactose a green alternative for synthesizing and preserving AgNPs.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Yingyuan Zhao, Zhaoxuan Wang, Shuxian Liu, Shiying Xie, Yinchun Xie, Ruifang Li, Hiroaki Oda
Summary: This research screens the best ratio of compound lyophilization protectants through single-factor experiments and response surface optimization experiments, and prepares excellent astaxanthin/BSA/chitosan nanosuspension (ABC-NPs) lyophilized powder, solving the problem of inconvenient storage and transportation of aqueous drugs.
Review
Biochemistry & Molecular Biology
Matthew S. Gatto, Wided Najahi-Missaoui
Summary: Nanoparticles have advantages and limitations as drug carriers, and lyophilization can increase their stability and the shelf life of drug products, but improvements are still needed in various aspects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Instruments & Instrumentation
Sanchit Arora, Sanat Kumar Dash, Dimple Dhawan, Prabhat Kumar Sahoo, Anil Jindal, Dalapathi Gugulothu
Summary: Lyophilization, also known as freeze-drying, is a technique utilized to enhance the long-term durability of nanoparticles for drug delivery applications. The process can cause stress to the nanoparticles, which can be alleviated by incorporating excipients, but it is important to optimize formulations and drying cycles to maintain stability. Proper characterization of the lyophilizate and nanoparticles is crucial for achieving these goals. This review discusses recent advancements in the field, addresses limitations, and suggests potential future directions for research.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Khaled ElKassas, Krishnakumar Chullipalliyalil, Michael McAuliffe, Sonja Vucen, Abina Crean
Summary: This study explores the use of UV-excited fluorescence spectroscopy as an alternative method for quantifying the reconstitution time of lyophilised formulations. By analyzing spectrographic information and using PCA, the variability of reconstitution time measurements is significantly reduced compared to traditional visual methods.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Marek Domin, Marek Szmigielski, Stanislaw Rudy
Summary: Apples of the Kosztela variety were freeze-dried and shredded into quarters, then rehydrated to achieve the texture and parameters of fresh fruit mousse. This method offers an alternative way to obtain mousses containing natural bioactive compounds that may be destroyed during heat treatment.
PRZEMYSL CHEMICZNY
(2023)
Article
Pharmacology & Pharmacy
Emilia Jakubowska, Michal Bielejewski, Bartlomiej Milanowski, Janina Lulek
Summary: The aim of this study was to investigate the effect of freeze-drying on the particle size of bottom-up processed cilostazol nanosuspension after redispersion. Optimal freeze-drying conditions were identified, and the freeze-dried nanocrystals retained their original size, polymorphic form, and improved dissolution rate.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Prakitr Srisuma, George Barbastathis, Richard D. Braatz
Summary: Freeze drying, also known as lyophilization, is a vacuum-sublimation drying process for pharmaceutical products. Microwave-assisted freeze drying is an alternative method that utilizes microwave irradiation to dry the product, reducing drying time by 70%-80%. This article provides exact and approximate analytical solutions for conventional, microwave-assisted, and hybrid freeze drying, serving as reference solutions for validation and offering computationally efficient and accurate results.
COMPUTERS & CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Medicinal
Juan Davagnino, John P. Gabrielson
Summary: This article presents a simple approach to develop a robust lyophilized formulation in the presence of salt and at low protein concentration, combined with a commercially viable lyophilization cycle. It can be used as a starting point for the development of protein-based pharmaceutical products and allows the production of placebo vials with no visual differences compared to the active product.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Girish Vallerinteavide Mavelli, Samira Sadeghi, Siddhesh Sujit Vaidya, Shik Nie Kong, Chester Lee Drum
Summary: The study shows that nanoscale thermostable exoshell can prevent protein aggregation and denaturation during freeze-drying process and have a near of 100% recovery rate upon reconstitution. Encapsulation of model substrate (horseradish peroxidase) within 8 nm tES cavity using charge complementation and pH-mediated controlled assembly resulted in 70% recovery of enzyme activity after lyophilized storage, representing a 14-fold improvement.
Article
Pharmacology & Pharmacy
Wei-Chung Luo, William Zhang, Rachel Kim, Heather Chong, Sajal M. Patel, Robin H. Bogner, Xiuling Lu
Summary: Controlled ice nucleation has minimal impact on nanoparticle stability, while the residence time in the freeze-concentrate has a greater influence. Replacing sucrose with trehalose improves the stability of freeze-dried liposomes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Nicole Haerdter, Raimund Geidobler, Ingo Presser, Gerhard Winter
Summary: Recently, microwave-assisted freeze-drying (MFD) has gained attention for its ability to significantly reduce the drying times of biopharmaceuticals compared to conventional freeze-drying (CFD). This study presents a new technical MFD setup that allows for the retrofitting of standard lyophilizers with microwave modules. Process data was collected to evaluate the speed, settings, and controllability of MFD processes, as well as the quality and stability of monoclonal antibody (mAb) formulations. The findings demonstrate that MFD can drastically shorten drying times, maintain good controllability, and produce stable lyophilizates with an elegant cake appearance.
Review
Pharmacology & Pharmacy
Emilia Jakubowska, Janina Lulek
Summary: This review discusses the application of lyophilization and its cryogenic modifications in producing solid dispersions and drug nanocrystals, emphasizing freeze-drying as a particle engineering tool. The focus is on the relationships between formulation and process parameters and the properties of the obtained material.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Serguei Tchessalov, Vito Maglio, Petr Kazarin, Alina Alexeenko, Bakul Bhatnagar, Ekneet Sahni, Evgenyi Shalaev
Summary: The purpose of this paper is to re-visit the design of three steps in the freeze-drying process and provide up-to-date recommendations for selecting drying conditions based on the physical-chemical properties of formulations and engineering considerations.
PHARMACEUTICAL RESEARCH
(2023)
Article
Engineering, Chemical
Francesca Susa, Tania Limongi, Michela Millone, Valentina Cauda, Roberto Pisano
Summary: Freeze-drying, also known as lyophilization, is advantageous for biopharmaceuticals but faces challenges that can be addressed with specific excipients. Research findings indicate that certain excipients can create uniform and solid lyophilized structures at lower concentrations, showing high tolerability by cell lines.
Article
Chemistry, Analytical
Arnab Mukherjee, Vincent A. Hackley
Article
Chemistry, Multidisciplinary
Hind El Hadri, Stacey M. Louie, Vincent A. Hackley
ENVIRONMENTAL SCIENCE-NANO
(2018)
Article
Thermodynamics
Omar Z. Sharaf, Nahla Rizk, Chakra P. Joshi, Maguy Abi Jaoude, Ashraf N. Al-Khateeb, Dimitrios C. Kyritsis, Eiyad Abu-Nada, Matthew N. Martin
ENERGY CONVERSION AND MANAGEMENT
(2019)
Article
Chemistry, Multidisciplinary
W. Cary Hill, Matthew S. Hull, Robert MacCuspie
Letter
Chemistry, Multidisciplinary
Jean-Marc Aublant, Charles A. Clifford, Emeric Frejafon, Toshiyuki Fujimoto, Vincent A. Hackley, Jan Herrmann, Angela R. Hight Walker, Debra L. Kaiser, Denis K. Koltsov, David J. Michael, Akira Ono, Gert Roebben, Gregory J. Smallwood, Naoyuki Taketoshi
Article
Environmental Sciences
Robert I. MacCuspie, W. Cary Hill, Daniel R. Hall, Andrey Korchevskiy, Cassidy D. Strode, Alan J. Kennedy, Mark L. Ballentine, Taylor Rycroft, Matthew S. Hull
Summary: Research on the emissions and user exposure scenarios of Fused Filament Fabrication (FFF) 3D printers reveals varying amounts of ultrafine particles (UFPs) and volatile organic compounds emitted during operation. Computational modeling and experimental validation provide actionable insights for designing lower exposure spaces, with forced clean airflows and proper positioning of room air ventilation diffusers being key factors in identifying these spaces. Workshop measurements and CFD modeling in an environmental chamber demonstrate agreement between model and experimental data, validating the findings.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2021)
Article
Thermodynamics
Omar Z. Sharaf, Nahla Rizk, Catherine J. Munro, Chakra P. Joshi, Waqas Waheed, Eiyad Abu-Nada, Anas Alazzam, Matthew N. Martin
Summary: This study investigated the thermal stability of plasmonic nanofluids under different heating conditions and coatings. It was found that the heating mode played a critical role in determining the effects on dispersion stability, coating transformations, optical properties, and wettability of the nanofluids. PVP was identified as the most suitable protective coating for solar photothermal applications. This work represents an important step towards commercial utilization of colloidally stable solar nanofluids with superior properties in the field.
ENERGY CONVERSION AND MANAGEMENT
(2021)
Article
Energy & Fuels
Omar Z. Sharaf, Nahla Rizk, Catherine J. Munro, Chakra P. Joshi, Dalaver H. Anjum, Eiyad Abu-Nada, Matthew N. Martin, Anas Alazzam
Summary: This study investigated the photostability of gold nanoparticles with different functional coatings under prolonged exposure to various radiation spectra. The stability of the nanofluids was influenced by the type of coating, radiation exposure mode, and spectrum. Despite subtle physicochemical transitions in the polymeric coatings, the gold nanoparticles maintained a high level of photostability, attributed to strong polymer-Au interactions and high surface grafting densities.
SOLAR ENERGY MATERIALS AND SOLAR CELLS
(2021)
Article
Engineering, Chemical
Nicholas G. Hallfors, Jeremy C. M. Teo, Peter M. Bertone, Chakra P. Joshi, Ajymurat Orozaliev, Matthew N. Martin, A. F. Isakovic
Summary: This study presents a novel process for refined control of white blood cells' elasticity using a combination of gold nanoparticles and a microelectrode array device. The capture and controlled deformation of white blood cells enriched with gold nanoparticles are demonstrated and quantified, showing enhanced controllability of DEP-related processes.
Article
Engineering, Chemical
Kaleb Duelge, George Mulholland, Michael Zachariah, Vincent A. Hackley
Summary: A critical comparison was made between the step-voltage mode and scan-voltage mode in differential mobility analysis (DMA). The difference in mean diameters measured by the two modes was found to be small under specific conditions. Two calibration methods for DMA were compared, and the use of calibration particles was found to minimize the effect of reduced scan time.
AEROSOL SCIENCE AND TECHNOLOGY
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Tae Joon Cho, Vincent Hackley, Vytas Reipa, Alessandro Tona, Christopher Sims, Natalia Farkas
Summary: We report on the synthesis and characterization of a stability-enhanced suspension of gold-polyethyleneimine conjugates (Au-PEIs). The nanoparticles showed excellent colloidal stability in aqueous environments and demonstrated significant cytotoxicity, making them a potential universal nanoscale positive control material for nanotoxicity studies.
2022 IEEE 22ND INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY (NANO)
(2022)
Article
Chemistry, Multidisciplinary
Tae Joon Cho, Justin M. Gorham, John M. Pettibone, Jingyu Liu, Jiaojie Tan, Vincent A. Hackley
Article
Biochemistry & Molecular Biology
Linwen Zhang, Jeremie Parot, Vincent A. Hackley, Illarion V. Turko
Article
Nanoscience & Nanotechnology
Richard J. Matyi, Robert MacCuspie
IEEE NANOTECHNOLOGY MAGAZINE
(2020)
Article
Chemistry, Analytical
Jiaojie Tan, Yong Yang, Hind El Hadri, Mingdong Li, Vincent A. Hackley, Michael R. Zachariah