Article
Neurosciences
Lacy K. Goode, Allison R. Fusilier, Natalie Remiszewski, Jacob M. Reeves, Kavitha Abiraman, Matthew Defenderfer, Jodi R. Paul, Lori L. McMahon, Karen L. Gamble
Summary: This study investigated the influence of sex and time-of-day on hippocampal neurophysiology and memory in mice. The results showed that both time-of-day and sex had an impact on memory performance and hippocampal synaptic activity. The study emphasizes the importance of understanding how sex and circadian rhythms affect hippocampal physiology, which can improve the relevance of treatments and inform the timing of therapy.
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Karl Peter Giese
Summary: Autophosphorylation of calcium/calmodulin-dependent kinase II (CaMKII) plays a critical role in synaptic potentiation by allowing kinase signaling to outlast NMDA receptor-dependent calcium influx. However, the role of CaMKII is conditional, depending on the developmental stage and location of the synapse.
Article
Biochemistry & Molecular Biology
Candice M. Roux, Pierre Lecouflet, Jean-Marie Billard, Elise Esneault, Marianne Leger, Pascale Schumann-Bard, Thomas Freret
Summary: Acute hippocampal slice preparations have been commonly used in studying the anti-amnesic properties of drug candidates on long-term potentiation (LTP). Genetic background is crucial in experimental design, considering the availability of various transgenic mouse models. In this study, LTP was compared between inbred and outbred mice, showing reduced LTP magnitude in outbred mice due to lower responsiveness to theta-frequency during conditioning stimuli. Overall, this study highlights the importance of considering animal models in electrophysiological experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Qin Gao, Jiangshun Huang, Juan Gao, Xueli Geng, Yuhang Ji, Haoze Li, Guoxing Wang, Bo Liang, Mei Wang, Zhisong Xiao, Ying Zhu, Paul K. Chu, Anping Huang
Summary: In this study, a functionalized honeycomb-like synaptic memristor (HLSM) was successfully fabricated, and the synaptic properties, such as short-term and long-term plasticity, were observed and controlled without gate voltage regulation. An artificial neural network (ANN) based on the potentiating/depressing characteristics showed an improved recognition rate from 54.2% to 91.8% simply by adjusting the input frequency.
MATERIALS TODAY PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Marlene F. Pereira, Ines M. Amaral, Catia Lopes, Catarina Leitao, Daniela Madeira, Joao P. Lopes, Francisco Q. Goncalves, Paula M. Canas, Rodrigo A. Cunha, Paula Agostinho
Summary: The study shows that L-alpha-aminoadipate (L-AA) affects astrocytes differently and impairs synaptic plasticity and memory. Injection of L-AA negatively impacts hippocampal long-term potentiation (LTP) and hippocampal-dependent memory in mice. D-serine administration can partially rescue the reduction in hippocampal LTP induced by L-AA exposure.
Article
Chemistry, Multidisciplinary
Ravindra Singh Bisht, Jaeseoung Park, Haoming Yu, Chen Wu, Nikhil Tilak, Sylvie Rangan, Tae J. Park, Yifan Yuan, Sarmistha Das, Uday Goteti, Hee Taek Yi, Hussein Hijazi, Abdullah Al-Mahboob, Jerzy T. Sadowski, Hua Zhou, Seongshik Oh, Eva Y. Andrei, Monica T. Allen, Duygu Kuzum, Alex Frano, Robert C. Dynes, Shriram Ramanathan
Summary: A single bias can tune the coupling strength between neighboring cells in a network of hydrogen-doped perovskite nickelate devices, suggesting potential use for neuromorphic learning and hardware implementation of artificial intelligence. Graded proton distribution in the inhomogeneous medium of the hydrogen-doped nickelate film enables this behavior, as shown by electrical transport measurements and spatially resolved diffraction and nanoprobe X-ray and scanning microwave impedance spectroscopic studies. Signal integration is further demonstrated through the coupling of various junctions.
Article
Endocrinology & Metabolism
Leigang Song, Huan Chen, Dan Qiao, Bohan Zhang, Fangzhen Guo, Yizhou Zhang, Chang Wang, Sha Li, Huixian Cui
Summary: Androgens regulate learning and memory in mice through ZIP9, which is mediated by the ERK1/2-eIF4E pathway. This study provides new experimental evidence for the improvement of learning and memory in Alzheimer's disease through androgen supplementation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Neurosciences
Wei Sun, Yang Yang, Zexiang Wu, Xiao Chen, Wen Li, Lei An
Summary: Exposure to cyanuric acid (CA) induced depression in hippocampal synaptic function but did not affect spatial memory retention in Morris water maze test in rats. The study provides evidence for the neurotoxic effect of CA and insights into its potential mechanisms.
NEUROTOXICITY RESEARCH
(2021)
Article
Environmental Sciences
Lingli Chen, Yuye Liu, Penghuan Jia, Hongli Zhang, Zhihong Yin, Dongfang Hu, Hongmei Ning, Yaming Ge
Summary: Lead exposure can cause neural damage and decrease the expression of synaptic plasticity-related proteins, leading to changes in cell morphology and function.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Shun Deng, Enming Zhang, Junyu Tao, Yunyang Zhao, Wenbo Huo, Hao Guo, Bingxin Zheng, Xiaoyuan Mu, Kezhu Yuan, Xuangen Deng, Hai Shen, Haibo Rong, Yanbo Ma, Wanping Bian
Summary: Graphene quantum dots (GQDs) have gained attention for their medicinal values but their effects on neurobehaviors and synaptic plasticity remain less explored. In this study, the locomotion of zebrafish larvae was evaluated after exposure to different concentrations of two types of GQDs (reduced-GQDs and graphene oxide QDs). The results showed that both GQDs affected the locomotor activity and ATP levels of the larvae, with stronger effects at higher concentrations. Thigmotactic effect, a behavior indicating anxiety, was induced by both GQDs and persisted even after depuration. Additionally, GQDs downregulated the mRNA levels of certain neurotransmitter receptors and total glutamine levels in the larvae. These findings highlight the potential adverse effects of GQDs on neurobehavior and synaptic plasticity.
Review
Neurosciences
Yanis Inglebert, Dominique Debanne
Summary: The importance of considering physiological levels of extracellular calcium concentration in studying functional plasticity is discussed in this study.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Fang-Fei Tao, Zi-Yu Wang, Ying Wang, Qian-Ru Lv, Peng-Peng Cai, Hai-Wen Min, Jian-Wei Ge, Chun-Yu Yin, Rui Cheng
Summary: Oxygen therapy plays a vital role in the development of bronchopulmonary dysplasia (BPD), but the effect of hippocampal cyclin-dependent kinase 5 (CDK5) on BPD-associated neurodevelopment deficits is not fully understood. Inhibition of CDK5 overactivation can improve cognitive deficits, neuronal apoptosis, and synaptic plasticity disorders in BPD mice.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Zhen Lan, Zhaoyou Meng, Biyao Lian, Mengying Liu, Tao Sun, Huan Sun, Zhi Liu, Zhenxin Hu, Qiang Guo, Jiqiang Zhang
Summary: The study demonstrated the crucial role of hippocampal E2 in regulating the structure and function of the hippocampus, indicating its significant impact on spatial learning and memory, as well as synaptic plasticity.
NEUROCHEMICAL RESEARCH
(2021)
Review
Neurosciences
Marco Capogna, Pablo E. Castillo, Arianna Maffei
Summary: GABAergic interneurons are highly diverse and play a crucial role in regulating neural circuits for learning and memory. Inhibitory synaptic plasticity in the hippocampus and neocortex is essential for circuit dynamics, with different interneuron types supporting unique roles.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Xiao-Dong Wang, Hong Xu, Zhen Yuan, Hao Luo, Ming Wang, Hua-Wei Li, Lin Chen
Summary: The study found that in native Chinese speakers, there is a shift of hemisphere dominance during semantic interpretation of Chinese lexical tones from right to left. The mismatch negativity response indicated right hemisphere dominance, while the behavioral reaction time showed a right ear listening advantage or left hemisphere dominance. This swap of hemisphere dominance depends on acoustic and functional cues of auditory inputs in the processing from sound to meaning.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Hui-Ping Tang, Hua-Rui Gong, Xu-Lai Zhang, Yi-Na Huang, Chuan-Yun Wu, Zheng-Quan Tang, Lin Chen, Ming Wang
Summary: Sodium salicylate enhances neural excitation by suppressing GABAergic synaptic transmission in the hippocampal dentate gyrus area, leading to hyperactivity in the central nervous system.
Article
Neurosciences
Fang-Qi Shu, Yun-Gang Lu, Hui-Ping Tang, Zeng-You Ye, Yi-Na Huang, Ming Wang, Zheng-Quan Tang, Lin Chen
Summary: The study found that resveratrol noncompetitively inhibits I-Gly in auditory neurons by decreasing the affinity of glycine to its receptor. These results suggest that the native glycine receptors but not GABA(A) receptors in central neurons are targets of resveratrol during clinical administrations.
BRAIN RESEARCH BULLETIN
(2021)
Article
Engineering, Biomedical
Fang Han, Xun Ma, Yuanxin Zhai, Leisha Cui, Lingyan Yang, Zhanchi Zhu, Ying Hao, Guosheng Cheng
Summary: A strategy for wireless electrical stimulation of stem cell scaffold using a conductive graphene substrate is reported. The wireless ES enhances neuronal differentiation and neurite formation without affecting the viability and stemness maintenance of neural stem cells, indicating potential for neural regenerative medicine.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Audiology & Speech-Language Pathology
Zhe Hu, Jia-Qiang Sun, Rui-Rui Guan, Lin Chen, Jing-Wu Sun, Xiao-Tao Guo
Summary: Children with cochlear implants showed deficits in both low-level acoustic encoding and higher-level cognitive processing in speech perception, especially in complex contexts. These sensory and cognitive processing deficits may contribute to the speech perception difficulties in children with cochlear implants.
Article
Engineering, Biomedical
Yuanxin Zhai, Quanwei Wang, Zhanchi Zhu, Wenlong Zheng, Sancheng Ma, Ying Hao, Lingyan Yang, Guosheng Cheng
Summary: This study constructed an exosomes-functionalized ECM (CBD-Exo/ECM) carrier by utilizing collagen binding domain peptide-modified exosomes (CBD-Exo) to interact with the extracellular matrix (ECM) for neural stem cells (NSCs) culture. The results demonstrated that CBD-Exo/ECM could promote neurogenesis of NSCs.
BIOMEDICAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Xinxin Zhang, Huiping Tang, Sitong Li, Yueqin Liu, Wei Wu, Yue Li, Chenchen Ma, Xiao Ma, Lin Chen, Yupeng Yang
Summary: The study demonstrates that Cdk5 in PV interneurons plays a crucial role in modulating the excitatory-inhibitory balance to control the plasticity of the visual cortex.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yue-Peng Zhou, Meng-Ji Mei, Xian-Zhang Wang, Sheng-Nan Huang, Lin Chen, Ming Zhang, Xin-Yan Li, Hai-Bin Qin, Xiao Dong, Shuang Cheng, Le Wen, Bo Yang, Xue-Fang An, Ao-Di He, Bing Zhang, Wen-Bo Zeng, Xiao-Jun Li, Youming Lu, Hong-Chuang Li, Haidong Li, Wei-Guo Zou, Alec J. Redwood, Simon Rayner, Han Cheng, Michael A. McVoy, Qiyi Tang, William J. Britt, Xin Zhou, Xuan Jiang, Min-Hua Luo
Summary: The study developed a congenital murine CMV infection mouse model that mimicked clinical manifestations of cCMV infection in infants, allowing for investigation of mechanisms of infection-induced brain damage and the effectiveness of antiviral treatment in mitigating neurological functions and brain damage.
Review
Behavioral Sciences
Senthilvelan Manohar, Guang-Di Chen, Dalian Ding, Lijie Liu, Jian Wang, Yu-Chen Chen, Lin Chen, Richard Salvi
Summary: Noise-induced hearing loss can disrupt the function of the hippocampus, which is involved in spatial navigation, memory, and emotion. It can affect hippocampal neurons and neurogenesis, leading to long-term spatial memory deficits. In addition, noise can also disrupt the regulation mechanism of the hypothalamic-pituitary axis, causing chronic stress responses. Therapeutic interventions that reduce oxidative stress and inflammation may help prevent and treat hearing loss.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Xiu-Yuan Liang, Zi-Hao Guo, Xiao-Dong Wang, Xiao-Tao Guo, Jing-Wu Sun, Ming Wang, Hua-Wei Li, Lin Chen
Summary: The study demonstrates evidence of involuntary consciousness during implicit memory retrieval, with mismatch negativity response and subsequent P3 component suggesting the involvement of unconscious awareness. Source analysis revealing moving dipoles from the frontal lobe to the insula further indicates the role of involuntary consciousness in implicit memory retrieval.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Cell Biology
Zhanchi Zhu, Yuanxin Zhai, Ying Hao, Quanwei Wang, Fang Han, Wenlong Zheng, Jing Hong, Leisha Cui, Wei Jin, Sancheng Ma, Lingyan Yang, Guosheng Cheng
Summary: The study demonstrates that engineered sEVs can effectively treat glioma by crossing the blood-brain barrier and specifically targeting brain tumors. The high targeting efficiency of these dual-modified sEVs for BBB and glioma was confirmed in vitro and in animal models.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Neurosciences
Yun-Yi Qi, Zi-Hao Guo, Xiao-Tao Guo, Rui-Rui Guan, Bin Luo, Jing-Wu Sun, Ming Wang, Hua-Wei Li, Lin Chen
Summary: In this study, evidence was reported for endogenous predictions established by the Zwicker tone illusion. MMN, P300, and theta oscillations were found to be recorded using an omission paradigm in subjects who can perceive Zwicker tone illusions. The MMN and P300 responses relied on attention, while theta oscillations did not. The increase in single-trial theta power with endogenous prediction was lateralized to the left frontal brain areas.
Article
Engineering, Biomedical
Zhongqing Liu, Zhaojun Wang, Zhanchi Zhu, Jing Hong, Leisha Cui, Ying Hao, Guosheng Cheng, Rui Tan
Summary: Many neurons undergo apoptosis after ischemic stroke. Crocetin (CRO), extracted from saffron, has been found to act as a neuroprotective agent for ischemic stroke. This study investigated the effect of CRO on neural stem cell (NSC) behaviors and subventricular zone neurogenesis. The results demonstrated that CRO promoted the neuronal differentiation of NSCs by activating subventricular zone neurogenesis to repair ischemic stroke.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Materials Science, Biomaterials
Jing Hong, Wenlong Zheng, Xiaoqiong Wang, Ying Hao, Guosheng Cheng
Summary: This review discusses recent advances in the use of biomedical polymer scaffolds to mimic bone marrow microenvironments for in vitro expansion of hematopoietic stem cells (HSCs), highlighting the potential future prospects in this field.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Yuanxin Zhai, Quanwei Wang, Zhanchi Zhu, Ying Hao, Fang Han, Jing Hong, Wenlong Zheng, Sancheng Ma, Lingyan Yang, Guosheng Cheng
Summary: This study demonstrates the use of modified exosomes as carriers for brain-derived neurotrophic factor (BDNF), which promotes the differentiation of oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes. Through intranasal administration, this method shows significant therapeutic effects on remyelination and motor coordination in demyelination model mice. Thus, this strategy of delivering BDNF via engineered exosomes provides a new approach for the treatment of central nervous system diseases.
BIOMATERIALS SCIENCE
(2022)