期刊
JOURNAL OF NANOPARTICLE RESEARCH
卷 14, 期 10, 页码 -出版社
SPRINGER
DOI: 10.1007/s11051-012-1177-x
关键词
Carbon dots; Endocytosis; Cytotoxicity; Fluorescent
Blue fluorescent carbon dots (C-dots) were synthesized and evaluated for their cytotoxicity and also for their optical imaging performance. The results showed that the C-dots could enter into the Hela cells in 15 min incubation and the uptake increased rapidly from 15 min to 2 h. In cytotoxicity study, C-dots were biocompatible and nontoxic to three human cells including two cancer cells (Hela and SMCC-7721) and one normal cell (HEK 293) in concentrations up to 500 mu g/mL. Since the endocytic interference factors, including NaN3, M beta CD, sucrose, and low temperature, could not play an inhibitory effect on C-dots entering into cells, the direct nonendocytic pathway for C-dots was speculated. The C-dots showed encouraging cell-imaging applications in vitro and in vivo. They entered into cells without any further functionalization, and the fluorescence property of these particles can be used for fluorescence-based cell-imaging applications.
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