Review
Pharmacology & Pharmacy
Chong Yu, Shuai Wang, Wing-Fu Lai, Dahong Zhang
Summary: Bladder cancer (BC) is the most common cancer of the urinary system and non-muscle-invasive bladder cancer (NMIBC) accounts for the majority of cases. Patients with NMIBC have a good survival rate but are at high risk for tumor recurrence and progression. The use of antitumor agents instilled into the bladder is the standard treatment for NMIBC, but their efficacy is limited due to chemo-resistance and poor drug retention. Chitosan-based nanoparticles offer a promising solution by enhancing drug penetration and improving biomedical applications in bladder cancer treatment.
Review
Pharmacology & Pharmacy
Yicheng Lu, Wei Huang, Meng Li, Aiping Zheng
Summary: In the past few decades, RNA-based drugs have shown potential for curing genetic defects by targeting disease-relevant genes. Exosomes, with their nanoscale size, high stability, biocompatibility, and low immunogenicity, have been explored as a promising carrier for RNA drug delivery. This article reviews and summarizes the progress and challenges of using exosomes for RNA therapy. Exosome-mediated RNA therapy has demonstrated potential in treating cancer, central nervous system disorders, COVID-19, and other diseases. However, further efforts are needed to overcome technological and logistic hurdles in order to fully exploit the potential of exosomes for RNA delivery.
Review
Chemistry, Multidisciplinary
Gan Lin, Jiajing Zhou, Hongwei Cheng, Gang Liu
Summary: The development of smart nanosystems has attracted significant attention in improving the efficacy of traditional nanomedicines. However, the diversity and scattered knowledge of these nanosystems pose challenges for their rational design. This review provides a summary of biological barriers and the strategies employed by smart nanosystems to overcome them, offering guidelines for the development of new-generation nanomedicines.
Review
Pharmacology & Pharmacy
Maria John Newton Amaldoss, Jia-Lin Yang, Pramod Koshy, Ashwin Unnikrishnan, Charles C. Sorrell
Summary: Inorganic nanoparticles used for drug delivery in cancer treatment offer numerous advantages, such as maximizing therapeutic effect through targeting ligands and minimizing side-effects. They have shown promising combined therapeutic capabilities, including anticancer effects and inhibition of cancer cell signaling pathways. Inorganic nanoparticles serve as synergistic platforms for RNA interference and as drug delivery agents for targeting cancer cell signaling pathways.
DRUG DISCOVERY TODAY
(2022)
Article
Engineering, Biomedical
Timothy Samec, Jessica Boulos, Serena Gilmore, Anthony Hazelton, Angela Alexander-Bryant
Summary: This review discusses the application of peptide-based delivery systems in cancer therapeutics. Peptide systems can alleviate systemic side effects caused by current delivery strategies and enhance therapeutic delivery and cancer targetability.
MATERIALS TODAY BIO
(2022)
Review
Chemistry, Multidisciplinary
Jingbo Qin, Ningqiang Gong, Zhihuan Liao, Shouwen Zhang, Peter Timashev, Shuaidong Huo, Xing-Jie Liang
Summary: This review summarizes the state of the art of design and construction of nanosystems used for mitochondria-targeted delivery in cancer treatment. It discusses the use of nanotechnology through various pathways such as energy metabolism interference, ROS regulation, mitochondrial protein targeting, mtDNA interference, mitophagy inducing, and combination therapy. Finally, it provides an overview of the major challenges and future prospects in this field.
Review
Pharmacology & Pharmacy
Yaqin Tang, Xingyou Liu, Meng Sun, Su Xiong, Nianting Xiao, Jianchao Li, Xiao He, Jing Xie
Summary: Extracellular vesicles (EVs) are small membrane-based vesicles that play a critical role in various physiological and pathological processes by serving as vehicles for intercellular communication. EVs have emerged as a promising cell-free therapy strategy for treating diseases, including cancer, due to their ability to transport various therapeutic molecules. Modifying or engineering EVs can improve their efficacy and specificity as drug carriers for cancer therapy. This review comprehensively outlines the biogenesis, isolation, and methodologies of EVs, as well as their biological functions, focusing on their specific applications as drug carriers in cancer therapy.
Review
Chemistry, Multidisciplinary
Lin-Jia Su, Mo-Xi Xu, Zi-Han Ji, Jia-Qing Zhu, Meng-Zhen Yu, Yi Wang, Yao-Xin Lin
Summary: Synthetic mRNA-based therapeutics are considered promising for the prevention and treatment of various diseases. They have advantages such as good safety, the ability to substitute for various functional proteins in the human body, and the flexibility and scalability of design and synthesis. This review summarizes the latest progress in mRNA nanotherapy and explores breakthroughs in mRNA delivery systems, including lipid, polymer, and polymer-lipid hybrid platforms. Additionally, it highlights recent innovations in mRNA-based nanotherapy for cancer treatment, including protein replacement, vaccines, cell-based therapies, and gene editing. The review also presents insights on the future prospects and challenges in utilizing mRNA-based nanotherapy against cancer.
Article
Oncology
Xiaokun Li, Lingmin Chen, Siyuan Luan, Jianfeng Zhou, Xin Xiao, Yushang Yang, Chengyi Mao, Pinhao Fang, Longqi Chen, Xiaoxi Zeng, Huile Gao, Yong Yuan
Summary: This review summarizes the application of nanoparticles in the treatment of esophageal cancer, including various types of nanoparticles and their efficacy and safety in chemotherapy, radiotherapy, phototherapy, and gene therapy. The use of nanomedicine in tumor imaging and diagnosis is also reviewed.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Zhoujiang Chen, Ranjith Kumar Kankala, Zhiyong Yang, Wei Li, Songzhi Xie, Hanmei Li, Ai-Zheng Chen, Liang Zou
Summary: Antibody-based cancer therapy has emerged as an efficient therapeutic strategy with diverse clinical manifestations and applications. Various drug delivery platforms have been developed to enhance therapeutic efficacy. Antibody-based drug delivery systems play an important role in cancer therapy by addressing the current challenges of antibody application and utilizing advanced drug delivery technologies.
Review
Chemistry, Analytical
Fan-Xin Song, Xiaojian Xu, Hengze Ding, Le Yu, Haochen Huang, Jinting Hao, Chenghao Wu, Rui Liang, Shaohua Zhang
Summary: Bladder cancer (BCa) is a common and expensive malignancy in the urinary system, with high rates of progression and recurrence. Current diagnosis methods for BCa, such as cystoscopy, biopsy, and cytology, have limitations in terms of invasiveness and accuracy. However, nanomaterials-based biosensors, like field-effect transistors (FETs), show promise in providing more accurate and sensitive urine cancer biomarkers. Nanomaterials also have potential in improving imaging techniques and contrast agents, such as magnetic resonance imaging (MRI), and in enhancing the efficacy and safety of intravesical chemotherapy through nanocarriers. Additionally, nanomedicine-based novel therapies, like photodynamic therapy (PDT), offer new treatment options for BCa. Future research may explore nanomotors and solid tumor disassociation strategies. This review summarizes the advances in BCa diagnosis and therapy.
Review
Chemistry, Multidisciplinary
Wioleta Borzecka, Adrian Dominski, Marek Kowalczuk
Summary: This perspective article summarizes the developments in the field of phthalocyanine-polymeric nanoparticle delivery systems for cancer photodynamic therapy over the past decade, highlighting the potential of these nanomaterials as advanced carriers for PDT while pointing out the need for further research.
Review
Medicine, Research & Experimental
Wenpan Li, Nicholas Little, Jonghan Park, Cole Alexander Foster, Jiawei Chen, Jianqin Lu
Summary: Nanoparticle drug delivery systems have improved antitumor efficacy, but achieving satisfactory distribution and penetration inside solid tumors, especially in stromal fibrous tumors, remains challenging. Tumor-associated fibroblasts reduce the drug delivery efficiency of nanoparticles, making them attractive targets for enhancing tumor delivery efficiency and efficacy of anticancer agents. Opportunities to summarize the underlying mechanisms of TAFs on obstructing nanoparticle-mediated drug delivery into tumors and discuss nanotherapeutic approaches for effectively targeting TAFs have been extensively explored.
MOLECULAR PHARMACEUTICS
(2021)
Review
Engineering, Biomedical
Dongdong Li, Doudou Hu, Hongxia Xu, Hirak K. Patra, Xiangrui Liu, Zhuxian Zhou, Jianbin Tang, Nigel Slater, Youqing Shen
Summary: Transdermal drug delivery is promising, especially through superficial routes. Microneedles can overcome limitations and deliver drugs into the dermal layer efficiently. They have been tested for pre-clinical chemotherapy, photothermal therapy, photodynamic therapy, and immunotherapy.
Article
Chemistry, Multidisciplinary
Zixia Zhang, Joao Conniot, Joana Amorim, Yiliang Jin, Rajendra Prasad, Xiyun Yan, Kelong Fan, Joao Conde
Summary: Nucleic acid-based therapy shows promise for treating brain tumors, but faces challenges in stability and targeting. Ongoing research and exploration in nucleic acid-based drugs may lead to more effective treatment strategies.
JOURNAL OF CONTROLLED RELEASE
(2022)
