Toxicological Effects of Titanium Dioxide Nanoparticles: A Review ofIn VivoStudies

Human and Environmental Exposure Assessment for Nanomaterials: An Introduction to this Issue

(2014) Vladimir Murashov   INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH

Understanding Workplace Processes and Factors that Influence Exposures to Engineered Nanomaterials

(2014) Susan R. Woskie et al.   INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH

Toxicoproteomic identification of TiO2nanoparticle-induced protein expression changes in mouse brain

(2011) Yu-Mi Jeon et al.   Animal Cells and Systems

Nanosized TiO2 caused minor airflow limitation in the murine airways

(2011) Maija Leppänen et al.   ARCHIVES OF TOXICOLOGY

Pulmonary response to surface-coated nanotitanium dioxide particles includes induction of acute phase response genes, inflammatory cascades, and changes in microRNAs: A toxicogenomic study

(2011) Sabina Halappanavar et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Assessing the potential exposure risk and control for airborne titanium dioxide and carbon black nanoparticles in the workplace

(2011) Min-Pei Ling et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Investigation of Gene Expression of MMP-2 and TIMP-2 mRNA in Rat Lung in Inhaled Nickel Oxide and Titanium Dioxide Nanoparticles

(2011) Yasuo MORIMOTO et al.   INDUSTRIAL HEALTH

Lung exposure of titanium dioxide nanoparticles induces innate immune activation and long-lasting lymphocyte response in the Dark Agouti rat

(2011) Åsa Gustafsson et al.   Journal of Immunotoxicology

An increase in mouse tumor growth by anin vivoimmunomodulating effect of titanium dioxide nanoparticles

(2011) Eun-Yi Moon et al.   Journal of Immunotoxicology

Metabonomic Studies of Biochemical Changes in the Serum of Rats by Intratracheally Instilled TiO2 Nanoparticles

(2011) Meng Tang et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Feasibility of Biomarker Studies for Engineered Nanoparticles

(2011) Ning Li et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Nanomaterials and Worker Health

(2011) Paul A. Schulte et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Overview of Current Toxicological Knowledge of Engineered Nanoparticles

(2011) Vincent Castranova   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Silica and titanium dioxide nanoparticles cause pregnancy complications in mice

(2011) Kohei Yamashita et al.   Nature Nanotechnology

Engineered nanomaterials: exposures, hazards, and risk prevention

(2011) Robert A Yokel et al.   Journal of Occupational Medicine and Toxicology

Nanotoxicology: a perspective and discussion of whether or not in vitro testing is a valid alternative

(2010) Martin J. D. Clift et al.   ARCHIVES OF TOXICOLOGY

Titanium dioxide induces different levels of IL-1β production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B

(2010) Tomohiro Morishige et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

P38-Nrf-2 Signaling Pathway of Oxidative Stress in Mice Caused by Nanoparticulate TiO2

(2010) Jue Wang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles

(2010) Renping Hu et al.   BIOMATERIALS

Metal Oxide Nanoparticles Induce Unique Inflammatory Footprints in the Lung: Important Implications for Nanoparticle Testing

(2010) Wan-Seob Cho et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Lung exposure to nanoparticles modulates an asthmatic response in a mouse model

(2010) S. Hussain et al.   EUROPEAN RESPIRATORY JOURNAL

Lack of skin carcinogenicity of topically applied titanium dioxide nanoparticles in the mouse

(2010) Fumio Furukawa et al.   FOOD AND CHEMICAL TOXICOLOGY

Exposure assessment of carbon nanotube manufacturing workplaces

(2010) Ji Hyun Lee et al.   INHALATION TOXICOLOGY

Signaling pathway of inflammatory responses in the mouse liver caused by TiO2 nanoparticles

(2010) Yaling Cui et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

The mechanism of oxidative damage in the nephrotoxicity of mice caused by nano-anatase TiO2

(2010) Jingfang Zhao et al.   Journal of Experimental Nanoscience

Hepatocyte apoptosis and its molecular mechanisms in mice caused by titanium dioxide nanoparticles

(2010) Yaling Cui et al.   JOURNAL OF HAZARDOUS MATERIALS

Small-Sized Titanium Dioxide Nanoparticles Mediate Immune Toxicity in Rat Pulmonary Alveolar Macrophages In Vivo

(2010) Ran Liu et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Dose Dependent In Vivo Metabolic Characteristics of Titanium Dioxide Nanoparticles

(2010) Meng Tang et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Systematic Influence Induced by 3 nm Titanium Dioxide Following Intratracheal Instillation of Mice

(2010) Yufeng Li et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Nanoparticle Emission Assessment Technique (NEAT) for the Identification and Measurement of Potential Inhalation Exposure to Engineered Nanomaterials—Part B: Results from 12 Field Studies

(2010) M. Methner et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE

Prenatal exposure to titanium dioxide nanoparticles increases dopamine levels in the prefrontal cortex and neostriatum of mice

(2010) Yuta Takahashi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Effects of Titanium Dioxide Nanoparticle Exposure on Neuroimmune Responses in Rat Airways

(2010) Mario Scuri et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Concept of Assessing Nanoparticle Hazards Considering Nanoparticle Dosemetric and Chemical/Biological Response Metrics

(2010) Erik K. Rushton et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Pulmonary Inflammation After Intraperitoneal Administration of Ultrafine Titanium Dioxide (TiO2) At Rest or in Lungs Primed with Lipopolysaccharide

(2010) Changsuk Moon et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration

(2010) Qian Bu et al.   NANOTECHNOLOGY

In vivoeffect of industrial titanium dioxide nanoparticles experimentally exposed to hairless rat skin

(2010) Koji Adachi et al.   Nanotoxicology

Particle length-dependent titanium dioxide nanomaterials toxicity and bioactivity

(2010) Raymond F Hamilton et al.   Particle and Fibre Toxicology

Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice

(2010) Karin S Hougaard et al.   Particle and Fibre Toxicology

Inhalation exposure to nanosized and fine TiO2 particles inhibits features of allergic asthma in a murine model

(2010) Elina M Rossi et al.   Particle and Fibre Toxicology

Reproductive and developmental toxicity studies of manufactured nanomaterials

(2010) Makoto Ema et al.   REPRODUCTIVE TOXICOLOGY

Lack of Significant Dermal Penetration of Titanium Dioxide from Sunscreen Formulations Containing Nano- and Submicron-Size TiO2 Particles

(2010) Nakissa Sadrieh et al.   TOXICOLOGICAL SCIENCES

Acute respiratory and systemic toxicity of pulmonary exposure to rutile Fe-doped TiO2 nanorods

(2010) Abderrahim Nemmar et al.   TOXICOLOGY

Effect of engineered nanoparticles on vasomotor responses in rat intrapulmonary artery

(2010) Arnaud Courtois et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Spleen injury and apoptotic pathway in mice caused by titanium dioxide nanoparticules

(2010) Na Li et al.   TOXICOLOGY LETTERS

Nano-Scaled Particles of Titanium Dioxide Convert Benign Mouse Fibrosarcoma Cells into Aggressive Tumor Cells

(2009) Kunishige Onuma et al.   AMERICAN JOURNAL OF PATHOLOGY

Nano Titanium Dioxide Particles Promote Allergic Sensitization and Lung Inflammation in Mice

(2009) Søren T. Larsen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

TiO2 nanoparticles translocation and potential toxicological effect in rats after intraarticular injection

(2009) Jiang-Xue Wang et al.   BIOMATERIALS

Oxidative stress in the brain of mice caused by translocated nanoparticulate TiO2 delivered to the abdominal cavity

(2009) Linglan Ma et al.   BIOMATERIALS

Toxicological characteristics of nanoparticulate anatase titanium dioxide in mice

(2009) Yanmei Duan et al.   BIOMATERIALS

Titanium Dioxide Nanoparticles Induce DNA Damage and Genetic Instability In vivo in Mice

(2009) B. Trouiller et al.   CANCER RESEARCH

Nanoparticle Inhalation Impairs Coronary Microvascular Reactivity via a Local Reactive Oxygen Species-Dependent Mechanism

(2009) A. J. LeBlanc et al.   Cardiovascular Toxicology

Synergistic genotoxicity caused by low concentration of titanium dioxide nanoparticles andp,p′-DDT in human hepatocytes

(2009) Yun Shi et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Titanium Dioxide Nanoparticles Aggravate Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

(2009) Rie Yanagisawa et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Workplace exposure to engineered nanoparticles

(2009) Sabine Plitzko   INHALATION TOXICOLOGY

In vivoacute toxicity of titanium dioxide nanoparticles to mice after intraperitioneal injection

(2009) Jinyuan Chen et al.   JOURNAL OF APPLIED TOXICOLOGY

Nanoparticles Transferred from Pregnant Mice to Their Offspring Can Damage the Genital and Cranial Nerve Systems

(2009) Ken Takeda et al.   JOURNAL OF HEALTH SCIENCE

Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology

(2009) G. Oberdörster   JOURNAL OF INTERNAL MEDICINE

From workplace air measurement results toward estimates of exposure? Development of a strategy to assess exposure to manufactured nano-objects

(2009) Derk Brouwer et al.   JOURNAL OF NANOPARTICLE RESEARCH

Nanoparticles and the Brain: Cause for Concern?

(2009) Günter Oberdörster et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Issues in the Development of Epidemiologic Studies of Workers Exposed to Engineered Nanoparticles

(2009) Paul A. Schulte et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Oxidative Stress and Asthma: Proteome Analysis of Chitinase-like Proteins and FIZZ1 in Lung Tissue and Bronchoalveolar Lavage Fluid

(2009) Lifeng Zhang et al.   JOURNAL OF PROTEOME RESEARCH

The safety of nanosized particles in titanium dioxide– and zinc oxide–based sunscreens

(2009) Marissa D. Newman et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Influence of Different Sizes of Titanium Dioxide Nanoparticles on Hepatic and Renal Functions in Rats with Correlation to Oxidative Stress

(2009) Geyu Liang et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Nanoparticle Inhalation Impairs Endothelium-Dependent Vasodilation in Subepicardial Arterioles

(2009) A. J. LeBlanc et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Interaction Between Nano-Anatase TiO2 and Liver DNA from Mice In Vivo

(2009) Na Li et al.   Nanoscale Research Letters

The Acute Liver Injury in Mice Caused by Nano-Anatase TiO2

(2009) Linglan Ma et al.   Nanoscale Research Letters

The known unknowns of nanomaterials: Describing and characterizing uncertainty within environmental, health and safety risks

(2009) Khara D. Grieger et al.   Nanotoxicology

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Nanosized titanium dioxide enhanced inflammatory responses in the septic brain of mouse

(2009) J.A. Shin et al.   NEUROSCIENCE

Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse

(2009) Midori Shimizu et al.   Particle and Fibre Toxicology

Surface area of particle administered versus mass in determining the pulmonary toxicity of ultrafine and fine carbon black: comparison to ultrafine titanium dioxide

(2009) Tina M Sager et al.   Particle and Fibre Toxicology

Pulmonary toxicity induced by three forms of titanium dioxide nanoparticles via intra-tracheal instillation in rats

(2009) Ran Liu et al.   Progress in Natural Science-Materials International

Airway Exposure to Silica-Coated TiO2 Nanoparticles Induces Pulmonary Neutrophilia in Mice

(2009) Elina M. Rossi et al.   TOXICOLOGICAL SCIENCES

Pulmonary Nanoparticle Exposure Disrupts Systemic Microvascular Nitric Oxide Signaling

(2009) Timothy R. Nurkiewicz et al.   TOXICOLOGICAL SCIENCES

Comparative pulmonary toxicity study of nano-TiO2 particles of different sizes and agglomerations in rats: Different short- and long-term post-instillation results

(2009) Norihiro Kobayashi et al.   TOXICOLOGY

Induction of chronic inflammation in mice treated with titanium dioxide nanoparticles by intratracheal instillation

(2009) Eun-Jung Park et al.   TOXICOLOGY

Exposure to manufactured nanoparticles in different workplaces

(2009) Derk Brouwer   TOXICOLOGY

Oxidative stress and apoptosis induced by nanosized titanium dioxide in PC12 cells

(2009) Shichang Liu et al.   TOXICOLOGY

Single-walled carbon nanotubes activate platelets and accelerate thrombus formation in the microcirculation

(2009) Peter Bihari et al.   TOXICOLOGY

Toxicity and penetration of TiO2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure

(2009) Jianhong Wu et al.   TOXICOLOGY LETTERS

Toxicity of nano-anatase TiO2to mice: Liver injury, oxidative stress

(2009) Huiting Liu et al.   TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY

Biochemical Toxicity of Nano-anatase TiO2 Particles in Mice

(2008) Huiting Liu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Cytotoxicity of Titanium Dioxide Nanoparticles in Mouse Fibroblast Cells

(2008) Cheng-Yu Jin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes

(2008) Su Jin Kang et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Impairment of NO-Dependent Relaxation in Intralobar Pulmonary Arteries: Comparison of Urban Particulate Matter and Manufactured Nanoparticles

(2008) Arnaud Courtois et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Efficacy of Simple Short-Term in Vitro Assays for Predicting the Potential of Metal Oxide Nanoparticles to Cause Pulmonary Inflammation

(2008) Senlin Lu et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The Acute Proinflammatory and Prothrombotic Effects of Pulmonary Exposure to Rutile TiO2 Nanorods in Rats

(2008) Abderrahim Nemmar et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Investigation of micronized titanium dioxide penetration in human skin xenografts and its effect on cellular functions of human skin-derived cells

(2008) Borbla Kiss et al.   EXPERIMENTAL DERMATOLOGY

Concordance BetweenInVitroandInVivoDosimetry in the Proinflammatory Effects of Low-Toxicity, Low-Solubility Particles: The Key Role of the Proximal Alveolar Region

(2008) K. Donaldson et al.   INHALATION TOXICOLOGY

Development of a Short-Term Inhalation Test in the Rat Using Nano-Titanium Dioxide as a Model Substance

(2008) Lan Ma-Hock et al.   INHALATION TOXICOLOGY

ESEM evaluations of muscle/nanoparticles interface in a rat model

(2008) Antonietta M. Gatti et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Surface chemistry influences cancer killing effect of TiO2 nanoparticles

(2008) Paul Thevenot et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction

(2008) Timothy R Nurkiewicz et al.   Particle and Fibre Toxicology

Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: role of particle surface area

(2008) Tina M Sager et al.   Particle and Fibre Toxicology

Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles

(2008) Jiangxue Wang et al.   TOXICOLOGY

Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystal phases

(2008) J WANG et al.   TOXICOLOGY LETTERS

Comparing fate and effects of three particles of different surface properties: Nano-TiO2, pigmentary TiO2 and quartz

(2008) Ben van Ravenzwaay et al.   TOXICOLOGY LETTERS